Affinity DataIC50: 0.362nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Binding affinity to 5HT2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Concentration required for inhibition of 5-hydroxytryptamine 2 receptor using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.46nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.76nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 2 receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 39.8nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 39.8nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of hERG potassium channel assessed as maximum inhibition rate at -80 mV holding potential incubated for 120 seconds by whole cell-automate...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human ERG expressed in CHO cells assessed as whole cell current by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against Potassium channel HERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of human ERG overexpressed in CHO cells by Qpatch methodMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Dainippon Pharmaceutical
Curated by ChEMBL
Dainippon Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against Alpha-1 adrenergic receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Experimental method: hERG patch clamp detection methodExperimental procedure: Compound preparation: the stock solution of a compound was diluted with...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Casmedchem Laboratory
Curated by ChEMBL
Casmedchem Laboratory
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:1. CHO-hERG cells which have been incubated overnight were added with sample buffer and incubated for 90 minutes at room temperature in darkness.2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 227nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibitory activity against dopamine receptor D2 by 3H ligand binding experiments.More data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Displacement of [3H]spiroperidol from D2 dopamine receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Cifa Universidad De Navarra
Curated by ChEMBL
Cifa Universidad De Navarra
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of [3H]BRL-43694 binding to rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Binding affinity to dopamine receptor D1More data for this Ligand-Target Pair
Affinity DataIC50: 4.47E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) in WIL2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta-2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Concentration required for inhibition of beta adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Dainippon Pharmaceutical
Curated by ChEMBL
Dainippon Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against alpha-2 adrenergic receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta-1 receptorMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
Chantest
Curated by ChEMBL
Chantest
Curated by ChEMBL
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetUbiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 4.69E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair