Affinity DataEC50: 667nMAssay Description:Inhibition of wild-type EGFR in human A431 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Massachusetts Medical School
Curated by ChEMBL
University Of Massachusetts Medical School
Curated by ChEMBL
Affinity DataEC50: 122nMAssay Description:Inhibition of wild-type HER2 phosphorylation in human BT-474 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MT...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataEC50: 1.75E+3nMAssay Description:Inhibition of EML4/ALK (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 66nMAssay Description:Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by...More data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs in presence of ceritinib by MTS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.73E+3nMAssay Description:Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.21E+3nMAssay Description:Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assay in presence of ceritinibMore data for this Ligand-Target Pair
Affinity DataEC50: 7.93E+3nMAssay Description:Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 57nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Affinity DataEC50: 286nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
Affinity DataEC50: 480nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human LoVo cells preincubated for 2 hrs followed by EGF stimulation and measured after...More data for this Ligand-Target Pair
Affinity DataEC50: 2.38E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human A-431 cells preincubated for 2 hrs followed by EGF stimulation and measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: 2.37E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human A-431 cells preincubated for 2 hrs followed by EGF stimulation and measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: 1.87E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H2073 cells preincubated for 2 hrs followed by EGF stimulation and measured ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.19E+3nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair