BindingDB PrimarySearch_ki

Found 27 of ic50 for monomerid = 50073765

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 17nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Cyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 25nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 26nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 26nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 31nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 31nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 31nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 46nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity protein kinase CLK4(Homo sapiens (Human))
Sri International

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 104nMAssay Description:Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 111nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 147nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity protein kinase CLK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 148nMAssay Description:Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
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Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 279nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair

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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 382nMAssay Description:Inhibition of human CDK1/cyclinB using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Cyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Sri International

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 573nMAssay Description:Inhibition of human CDK4/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Sri International

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: >1.00E+3nMAssay Description:Inhibition of human CDK6/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: >1.00E+3nMAssay Description:Inhibition of human CLK3 using ERMRPRKRQGSVRRRV as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair

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Cyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 1.40E+3nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair

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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 3.00E+3nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair

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Interferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 3.00E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 5.10E+3nMAssay Description:Inhibit of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 5.10E+3nMAssay Description:Inhibit of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair

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Protein kinase C alpha type(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 1.35E+4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair

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Protein kinase C alpha type(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 1.35E+4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Palack£

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: >2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-His6 tagged PDGFRalpha (Q551 to L1089 residues) expressed in Sf9 insect cells using poly(Ala,Glu,Lys,T...More data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 1.50E+5nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)

IC50: 1.50E+5nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair

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Filter my 27 hits

Targets 19▿
- Cyclin-dependent kinase 1 3
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 3
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 2
- cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma 2
- Protein kinase C alpha type 2
- Epidermal growth factor receptor 2
- Dual specificity protein kinase CLK1 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- Platelet-derived growth factor receptor alpha 1
- Interferon-induced, double-stranded RNA-activated protein kinase 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 1
- Cyclin-dependent kinase 5 activator 1 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 1
Publications 5▿
- Bioorg Med Chem Lett 9: 91-6 (1999) 9
- J Med Chem 61: 9105-9120 (2018) 8
- Bioorg Med Chem Lett 27: 406-412 (2017) 7
- Bioorg Med Chem 25: 6523-6535 (2017) 2
- Bioorg Med Chem Lett 21: 4108-14 (2011) 1
Institutions 4▿
- Palack£ 10
- Novartis Pharmaceuticals 9
- Sri International 7
- Weill Cornell Medical College 1
Affinity: 17 to 1.5E+5 nM▿
- IC50 27
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1