TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 3.40nMAssay Description:Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 StaR domain (569 to 836 residues) (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 5.70nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 9.60nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebrocortical membranes after 60 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 10nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 10nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 10nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 12nMAssay Description:Tested for displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 13nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 15nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 16.3nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 18.7nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 19nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 20nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 20nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories
Curated by PDSP Ki Database
Merck Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 21nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 36nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Antagonist activity at human mGLUR1More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by PDSP Ki Database
F. Hoffmann-La Roche
Curated by PDSP Ki Database
Affinity DataKi: 36.3nMAssay Description:Binding affinity to human mGluR5More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Competitive inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Competitive inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]R214127 from rat cloned mGluR1 receptor expressed in CHO-T-Rex cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 3.00E+4nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair