Found 31 of ic50 for monomerid = 50101815 TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Suntory Institute For Biomedical Research
Curated by ChEMBL
Suntory Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
Affinity DataIC50: 378nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Kyoto Pharmaceutical University
Curated by ChEMBL
Kyoto Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.54E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana
Curated by ChEMBL
Federal University Of Parana
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells assessed as reversal of BCRP-mediated mitoxantrone resistance and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 7.87E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection met...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4RMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferensMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Institut De Pharmacologie (Ua 589 Cnrs)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparationMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux after 5 mins by flu...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 2.41E+4nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunitMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
