BindingDB PrimarySearch_ki

Found 67 of ic50 for monomerid = 50157879

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 20nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair

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3D Structure (crystal)

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 60nMAssay Description:Antagonist activity at human GST-tagged IGF-1R (950 to 133 residues) expressed in baculovirus after 5 mins in presence of [gamma33P]-ATP by top count...More data for this Ligand-Target Pair

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3D Structure (crystal)

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 65nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...More data for this Ligand-Target Pair

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3D Structure (crystal)

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 130nMAssay Description:Displacement of [3H]-dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 130nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Insulin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 244nMAssay Description:Inhibition of full length insulin receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 800nMAssay Description:Inhibition of PDGFRalpha-V561D mutant (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 892nMAssay Description:Inhibition of full length insulin receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 ...More data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 1.00E+3nMAssay Description:Inhibition of Ins receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Insulin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 1.02E+3nMAssay Description:Inhibition of insulin receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 1.40E+3nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 1.40E+3nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Receptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 1.70E+3nMAssay Description:Inhibition of ERBB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB
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Fibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 2.70E+3nMAssay Description:Inhibition of FGFR2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Activin receptor type-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 2.90E+3nMAssay Description:Inhibition of ACVR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 3.20E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 3.30E+3nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 3.30E+3nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 4.00E+3nMAssay Description:Inhibition of SRC (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Fibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 4.30E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 5.00E+3nMAssay Description:Inhibition of FGFR4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 5.20E+3nMAssay Description:Inhibition of EGFR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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ALK tyrosine kinase receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >5.50E+3nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB KEGG
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Tyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 5.60E+3nMAssay Description:Inhibition of LCK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB Reactome pathway
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Tyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 5.60E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 6.30E+3nMAssay Description:Inhibition of cKIT (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB Reactome pathway
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 7.10E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 7.10E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 7.60E+3nMAssay Description:Inhibition of BTK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: 8.90E+3nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >9.00E+3nMAssay Description:Inhibition of PI3K-beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >9.00E+3nMAssay Description:Inhibition of PI3K-alpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >9.10E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >9.10E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >9.10E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Fibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of CDK2A (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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MAP kinase-activated protein kinase 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK5 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Aurora kinase A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of AURKA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Mitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of MAPK14 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of CDK4D1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Non-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Tyrosine-protein kinase JAK3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Hepatocyte growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of cMET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)

IC50: >1.00E+4nMAssay Description:Inhibition of PRKACA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

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Targets 50▿
- Insulin-like growth factor 1 receptor 5
- Insulin receptor 4
- Epidermal growth factor receptor 3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Tyrosine-protein kinase Lck 2
- Ephrin type-B receptor 4 2
- Proto-oncogene tyrosine-protein kinase receptor Ret 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Tyrosine-protein kinase JAK1 2
- Vascular endothelial growth factor receptor 2 2
- Potassium voltage-gated channel subfamily H member 2 2
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Tyrosine-protein kinase receptor UFO 1
- Activin receptor type-1 1
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Tyrosine-protein kinase SYK 1
- Mast/stem cell growth factor receptor Kit 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- ALK tyrosine kinase receptor 1
- Hepatocyte growth factor receptor 1
- Fibroblast growth factor receptor 4 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Mitogen-activated protein kinase 14 1
- Fibroblast growth factor receptor 1 1
- Aurora kinase A 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 1
- Fibroblast growth factor receptor 2 1
- Glycogen synthase kinase-3 beta 1
- Fibroblast growth factor receptor 3 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase PLK1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- Tyrosine-protein kinase ABL1 1
- Tyrosine-protein kinase CSK 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Tyrosine-protein kinase Lyn 1
- Platelet-derived growth factor receptor alpha 1
- RAC-alpha serine/threonine-protein kinase 1
- Cyclin-dependent kinase 2 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Tyrosine-protein kinase ZAP-70 1
- MAP kinase-activated protein kinase 2 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Proto-oncogene tyrosine-protein kinase Src 1
- MAP kinase-activated protein kinase 5 1
Publications 3▿
- Bioorg Med Chem Lett 26: 2057-64 (2016) 55
- Bioorg Med Chem Lett 26: 2065-7 (2016) 11
- J Med Chem 61: 2166-2210 (2018) 1
Institutions 2▿
- Novartis Institutes For Biomedical Research 66
- St. John'S University 1
Affinity: 20 to 1.0E+4 nM▿
- IC50 67
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1