Found 79 of ic50 for monomerid = 50179360 TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of human N-terminal His-tagged SIRT1 (183 to 664 residues) expressed in Escherichia coli using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate pre...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human N-terminal His-tagged SIRT1 (183 to 664 residues) expressed in Escherichia coli using Ac-Tyr-Lys-Leu-Lys(Ac)-AMC as substrate pre...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 297nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) using histone deacetylase as substrate incubated for 4 hrs by homogenous fluorescent deacetylase ass...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of human NPP3 transfected in COS7 cells using pNP-TMP as substrate incubated for 35 minsMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant NPP3 expressed in COS-7 cell membrane at 100 uM using p-nitrophenyl thymidine monophosphate substrate incubated for 3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at rat P2X1 receptorMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using histone deacetylase as substrate incubated for 4 hrs by homogenous fluorescent deacetylase ass...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of human recombinant N-terminal His6 tagged NPP3 expressed in baculovirus infected Sf9 cell membranes using pNP-TMP as substrate preincuba...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of human NPP3 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of human full length NPP3 expressed in African green monkey COS7 cell membrane fraction using p-nitrophenyl-5'-thymidine monophosphate as ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of human NPP3 expressed in African green monkey COS7 cell membranes pre-incubated for 10 mins before pNP-TMP substrate addition and furthe...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Innsbruck
Curated by ChEMBL
University Of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of recombinant human PTP1B using pNPP as substrate assessed as residual activity after 30 mins by spectrometric methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 (56 to 356 residues) expressed in Escherichia coli using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate prei...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT5 (34 to 302 residues) expressed in Escherichia coli using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate prei...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Innsbruck
Curated by ChEMBL
University Of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
TargetP2X purinoceptor 1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)
Curated by ChEMBL
Gwangju Institute Of Science And Technology (Gist)
Curated by ChEMBL
Affinity DataIC50: 4.27E+3nMAssay Description:Antagonist activity at human P2X1 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced calcium influx preincubated for 30 m...More data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 3(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human NTPDase3 expressed in green monkey Cos-7 cells using ATP as substrate preincubated for 3 mins followed by substrate addition by m...More data for this Ligand-Target Pair
TargetP2X purinoceptor 1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)
Curated by ChEMBL
Gwangju Institute Of Science And Technology (Gist)
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Antagonist activity at human P2X1 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced calcium flux measured for 30 secs at 0.4 s...More data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 3(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of human NTPDase3 expressed in African green monkey COS7 cell membrane fraction using ATP as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.68E+3nMAssay Description:Antagonist activity at P2X1 receptor in rat vas deferens assessed as inhibition of alpha/beta-meATP-induced calcium influxMore data for this Ligand-Target Pair
Affinity DataIC50: 4.73E+3nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Russian Academy Of Sciences
Curated by ChEMBL
Russian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant TDP1 (unknown origin) using 5'-32P-labeled N14Y DNA substrate incubated for 20 mins by PAGE analysisMore data for this Ligand-Target Pair
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Russian Academy Of Sciences
Curated by ChEMBL
Russian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant TDP1 (unknown origin) expressed in Escherichia coli Rosetta2(DE3) using 3'-FITC labeled 13-mer DNA as substrate by Gyrasol ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 5.45E+3nMAssay Description:Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-peptide as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.64E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant sirtuin 1 using fluorogenic HDAC substrate measured after 20 mins by fluorimetry assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase(Leishmania infantum)
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
Curated by ChEMBL
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Leishmania infantum SIR2RP1 expressed in Escherichia coli in presence of NAD+ by fluorimetric methodMore data for this Ligand-Target Pair
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 7.77E+3nMAssay Description:Inhibition of human recombinant NPP1 expressed in COS-7 cell membrane at 100 uM using p-nitrophenyl thymidine monophosphate substrate incubated for 3...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 7.77E+3nMAssay Description:Inhibition of human NPP1 transfected in COS7 cells using pNP-TMP as substrate incubated for 35 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preinc...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of Cbx7 (unknown origin) using FITC-labeled SETDB1-K1170me3 peptide as probe by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of NPP1 (unknown origin) using pNP-TMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of human full length NPP1 expressed in African green monkey COS7 cell membrane fraction using p-nitrophenyl-5'-thymidine monophosphate as ...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of human NPP1 expressed in African green monkey COS7 cell membranes pre-incubated for 10 mins before pNP-TMP substrate addition and furthe...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT5 (34 to 302 residues) expressed in Escherichia coli using Ac-Tyr-Lys-Leu-Lys(Ac)-AMC as substrate prei...More data for this Ligand-Target Pair
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human mitochondrial HSP60/HSP10 expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding pre...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+4nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+4nMAssay Description:Antagonist activity against human P2X2R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+4nMAssay Description:Antagonist activity against human P2X5R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 1(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human CD39 expressed in green monkey Cos-7 cells using ATP as substrate preincubated for 3 mins followed by substrate addition by malac...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.61E+4nMAssay Description:Antagonist activity at human P2X5 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 1(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of human NTPDase1 expressed in African green monkey COS7 cell membrane fraction using ATP as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant sirtuin 2 using fluoro-lysine sirtuin 2 deacetylase substrate measured after 60 mins by fluorimetry assayMore data for this Ligand-Target Pair
