Found 120 of ic50 for monomerid = 50346601 
Affinity DataIC50: 5nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant PTP1B using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance base...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant TCPTP using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance base...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of PTP1B (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate and measured 30 mins post substra...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human PTP1B using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast using pNPP as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PTP1B using pNPP as substrate assessed as rate of hydrolysis incubated for 10 mins prior to substrate addition measur...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) assessed as pNPP hydrolysis after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human TCPTP expressed in Escherichia coli using pNPP as substrate preincubated for 10 min...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMpH: 6.5Assay Description:Briefly, the tested compounds were solubilized in DMSO and serially diluted into concentrations for the inhibitory test. The assays were carried out ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate measured after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 2 mins by colorimetric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of recombinant human PTP1B using pNNP as substrate after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate after 3 mins by colorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain (91 to 1053 residues) expressed in Escherichia coli BL21-codon plus (DE3) using pNPP as substr...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of PTP1B (unknown origin) by SpectraMax 340 microplate reader AnalysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of TCPTP (unknown origin) by SpectraMax 340 microplate reader AnalysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultila...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of phospholipase A2More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain assessed as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.32E+3nMAssay Description:Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain expressed in Escherichia coli BL21-CodonPlus (DE3) using pNPP as substrate measured for 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric anal...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human AKR1B10 overexpressed in human HeLa cells assessed as inhibition of [1-14C]farnesol reduction pretreated f...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University Of Pharmaceutical Sciences
Curated by ChEMBL
Osaka University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.23E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrat...More data for this Ligand-Target Pair
