BindingDB PrimarySearch

Found 52 of ic50 for monomerid = 50532181

Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

IC50: 14nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair

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3D Structure (crystal)

Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: 20nMAssay Description:Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...More data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: 261nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged TrkA (440 to end residues) expressed in baculovirus infected Sf21 insect cells using KKKSPGEYV...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged FGFR3 (447 to 761 residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged SGK1 (61 to 431 residues) expressed in baculovirus infected Sf21 insect cells Akt/SGK peptide as substrateMore data for this Ligand-Target Pair

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Lysine--tRNA ligase(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged SYK expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1) as substrateMore data for this Ligand-Target Pair

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Angiopoietin-1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged TIE2 (771 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1)...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Abl (27 to end residues) expressed in baculovirus infected Sf21 insect cells using Abltide as ...More data for this Ligand-Target Pair

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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged CDK1/cyclinB expressed in baculovirus infected Sf21 insect cells using Abltide as s...More data for this Ligand-Target Pair

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Casein kinase II subunit alpha(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full length His6-tagged CK2alpha expressed in baculovirus infected Sf21 insect cells using Casein Kinase 2 substrate peptideMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged c-kit (544 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1)...More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His-tagged SRC expressed in baculovirus infected Sf9 insect cells using Poly-(Glu4:Tyr) as substrate measu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (696 to end residues) expressed in baculovirus infected Sf21 insect cells using Angiotensin II peptide...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR1 (456 to 765 residues) expressed in baculovirus infected Sf21 insect cells using IGF-IRtide (12-527) a...More data for this Ligand-Target Pair

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Tyrosine-protein kinase Fyn(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 insect cells using Src peptide as substrateMore data for this Ligand-Target Pair

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Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged IGF1R (959 to end residues) expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged insulin receptor (1005 to 1310 residues) expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 8(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His-tagged JNK1alpha1 expressed in baculovirus infected Sf21 insect cells using ATF2 as substrateMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 9(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His-tagged JNK2alpha2 expressed in baculovirus infected Sf21 insect cells using ATF2 as substrateMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged LYN expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1) as substra...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human MAPK2 using myelin basic protein as substrateMore data for this Ligand-Target Pair

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Hepatocyte growth factor receptor(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged MET (974 to end residues) expressed in baculovirus infected Sf21 insect cells using KKKSPGEYVNIEFG as subs...More data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged MSK1 (2 to end residues) expressed in baculovirus infected Sf21 insect cells using Crosstide as substrateMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PDGFRbeta (557 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) ...More data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of full length human untagged PKAalpha expressed in Escherichia coli BL21 (DE3) pLysS cells using Kemptide as substrateMore data for this Ligand-Target Pair

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RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged PKBalpha expressed in baculovirus infected Sf21 insect cells using Crosstide as substrateMore data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged (2 to end residues) PKCbeta expressed in baculovirus infected Sf21 insect cells using Histone H1 as substr...More data for this Ligand-Target Pair

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Protein kinase C zeta type(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human PKCzetaMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 14(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged SAPK2a expressed in baculovirus infected Sf21 insect cells using MBP as substrateMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged c-RAF Y340D/Y341D double mutant (306 to 648 residues) expressed in baculovirus infected Sf9 insect cells us...More data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged GSK3beta H350L mutant expressed in baculovirus infected Sf21 insect cells using phosphoglycogen synthase p...More data for this Ligand-Target Pair

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Tyrosine-protein kinase Lck(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged LCK expressed in baculovirus infected Sf21 insect cells using Src peptide as substrateMore data for this Ligand-Target Pair

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Protein kinase C gamma type(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged PKCgamma expressed in baculovirus infected Sf21 insect cells using Histone H1 as substrateMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged Flt3 (564 to end residues) expressed in baculovirus infected Sf21 insect cells using Abltide as substrateMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PLK1 expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged/C-terminal His6-tagged MEK1 expressed in Escherichia coli using MBP as substrateMore data for this Ligand-Target Pair

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3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PDK1 (52 to end residues) expressed in baculovirus infected Sf21 insect cells using PDKtide as substrateMore data for this Ligand-Target Pair

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Protein kinase C alpha type(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged PKCalpha expressed in baculovirus infected Sf21 insect cells using Histone H1 as substrateMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 11(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged SAPK2b2 expressed in baculovirus infected Sf21 insect cells using MBP as substrateMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged CHK1 expressed in baculovirus infected Sf21 insect cells using CHKtide as substrateMore data for this Ligand-Target Pair

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Tyrosine-protein kinase CSK(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged CSK expressed in Escherichia coli BL21 (DE3) cells using Poly (Glu4Tyr) as substrateMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 1(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged Flt1 (783 to end residues) expressed in baculovirus infected Sf21 insect cells using KKKSPGEYVNIEFG as subs...More data for this Ligand-Target Pair

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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged IKKbeta expressed in baculovirus infected Sf21 insect cells using IKKtide as substrateMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His-tagged KDR (790 to end residues) expressed in baculovirus infected Sf21 insect cells using myelin basic protein as...More data for this Ligand-Target Pair

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Aurora kinase A(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of recombinant full-length human N-terminal His6-tagged AuroraA expressed in baculovirus infected Sf21 insect cells using Kemptide as subs...More data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-1/alpha-2/alpha-3/alpha-4/alpha-5/alpha-6/beta-1/beta-2(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His-tagged p70S6K expressed in baculovirus infected Sf21 insect cells using CKRRRLASLR as substrateMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 12(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged SAPK3 expressed in Escherichia coli using MBP as substrateMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full-length C-terminal His6-tagged ZAP70 expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1) as subst...More data for this Ligand-Target Pair

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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human full length C-terminal His6-tagged Cdk2/human full length N-terminal GST-tagged Cyclin A expressed in baculovirus infected Sf21 i...More data for this Ligand-Target Pair

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Rho-associated protein kinase 2(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL

BDBM50532181(CHEMBL4474690)

IC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged (11 to 552 residues) ROCK2 expressed in baculovirus infected Sf21 insect cells using Long S6 Kinase as sub...More data for this Ligand-Target Pair

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Targets 51▿
- Macrophage colony-stimulating factor 1 receptor 2
- Angiopoietin-1 receptor 1
- Lysine--tRNA ligase 1
- Mast/stem cell growth factor receptor Kit 1
- Hepatocyte growth factor receptor 1
- Mitogen-activated protein kinase 14 1
- Casein kinase II subunit alpha 1
- Glycogen synthase kinase-3 beta 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Ribosomal protein S6 kinase alpha-1/alpha-2/alpha-3/alpha-4/alpha-5/alpha-6/beta-1/beta-2 1
- Rho-associated protein kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- Serine/threonine-protein kinase Sgk1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Tyrosine-protein kinase Lck 1
- Mitogen-activated protein kinase 9 1
- Insulin-like growth factor 1 receptor 1
- High affinity nerve growth factor receptor 1
- Epidermal growth factor receptor 1
- Mitogen-activated protein kinase 8 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 2 1
- Fibroblast growth factor receptor 1 1
- Aurora kinase A 1
- Vascular endothelial growth factor receptor 1 1
- Fibroblast growth factor receptor 3 1
- Serine/threonine-protein kinase PLK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 11 1
- Protein kinase C beta type 1
- Mitogen-activated protein kinase 10 1
- Protein kinase C gamma type 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Tyrosine-protein kinase Lyn 1
- Protein kinase C alpha type 1
- Platelet-derived growth factor receptor alpha 1
- Ribosomal protein S6 kinase alpha-5 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk1 1
- Platelet-derived growth factor receptor beta 1
Publications 1▿
- Bioorg Med Chem Lett 29: 873-877 (2019) 52
Institutions 1▿
- Japan Tobacco 52
Affinity: 14 to 1.0E+3 nM▿
- IC50 52
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1