Affinity DataKi: 1.27nM ΔG°: -12.0kcal/mole IC50: 1.90nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human MMP25 by fluorometric assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP8 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against human matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of rat matrix metalloprotease 13More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human matrix metalloprotease 9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of gelatinase-B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:In vitro inhibitory activity against collagenase-3 (matrix metalloprotease-13).More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of neutrophil collagenase (Matrix metalloprotease-8)More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human Matrix metalloprotease-8More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibitory activity against human Matrix metalloprotease-2More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant MMP9 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human MMP9 by fluorometric assayMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human proMMP9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate ...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibitory activity against human Matrix metalloprotease-13More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP9 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6.80nMT: 2°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital Of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human MMP8 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against Matrix metalloprotease-13More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13.More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human matrix metalloprotease-14More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against Matrix metalloprotease-9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Procter And Gamble Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:In vitro ability to inhibit matrix metalloprotease-9.More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:In vitro inhibitory activity against gelatinase-A (matrix metalloprotease-2).More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human matrix metalloprotease 2More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human Matrix metalloprotease-2More data for this Ligand-Target Pair