Compile Data Set for Download or QSAR
maximum 50k data
Found 10 of ic50 for monomerid = 86748
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human SERT expressed in CHO cells assessed as reduction of [3H]-5-HT re-uptake preincubated for 10 mins followed by [3H]-5-HT addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  60nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  180nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  538nMAssay Description:Inhibition of human NET expressed in CHO cells assessed as reduction of [3H]-NE re-uptake preincubated for 10 mins followed by [3H]-NE addition measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTransporter(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  2.51E+5nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  3.16E+5nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  5.01E+6nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM86748(CAS_386750-22-7 | Desvenlafaxine | NSC_6918664 | O...)
Affinity DataIC50:  2.00E+7nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed