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Compile Data Set for Download or QSAR

Found 673 hits of affinity data for UniProtKB/TrEMBL: P31153   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507716
PNG
(7-chloro-4-(methylamino)-1-phenyl- quinazolin-2(1H...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H12ClN3O/c1-17-14-12-8-7-10(16)9-13(12)19(15(20)18-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507717
PNG
(4-(dimethylamino)-7-chloro-1-(4- fluorophenyl)-hyd...)
Show SMILES CN(C)c1nc(=O)n(-c2ccc(F)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H13ClFN3O/c1-20(2)15-13-8-3-10(17)9-14(13)21(16(22)19-15)12-6-4-11(18)5-7-12/h3-9H,1-2H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507718
PNG
(7-chloro-5-methoxy-4-(methylamino)- 1-phenylquinaz...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(OC)c12
Show InChI InChI=1S/C16H14ClN3O2/c1-18-15-14-12(8-10(17)9-13(14)22-2)20(16(21)19-15)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,18,19,21)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507719
PNG
(7-bromo-4-(methylamino)-1-phenyl- quinazolin-2(1H)...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12
Show InChI InChI=1S/C15H12BrN3O/c1-17-14-12-8-7-10(16)9-13(12)19(15(20)18-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507720
PNG
(4-(dimethylamino)-7-chloro-1-(5- fluoro-3-hydroxyp...)
Show SMILES CN(C)c1nc(=O)n(-c2cc(O)cc(F)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H13ClFN3O2/c1-20(2)15-13-4-3-9(17)5-14(13)21(16(23)19-15)11-6-10(18)7-12(22)8-11/h3-8,22H,1-2H3
PDB

UniProtKB/SwissProt
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UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507721
PNG
(7-chloro-6-methoxy-4-(methylamino)- 1-phenylquinaz...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)c(OC)cc12
Show InChI InChI=1S/C16H14ClN3O2/c1-18-15-11-8-14(22-2)12(17)9-13(11)20(16(21)19-15)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,18,19,21)
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507723
PNG
(4-azetidinyl-7-chloro-1-(5-fluoro-3- hydroxy-pheny...)
Show SMILES Oc1cc(F)cc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CCC1
Show InChI InChI=1S/C17H13ClFN3O2/c18-10-2-3-14-15(6-10)22(12-7-11(19)8-13(23)9-12)17(24)20-16(14)21-4-1-5-21/h2-3,6-9,23H,1,4-5H2
PDB

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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507724
PNG
(7-chloro-4-(3-hydroxyazetidin-1-yl)-1- phenylquina...)
Show SMILES OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H14ClN3O2/c18-11-6-7-14-15(8-11)21(12-4-2-1-3-5-12)17(23)19-16(14)20-9-13(22)10-20/h1-8,13,22H,9-10H2
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507725
PNG
(7-Chloro-1-(5-fluoro-3-hydroxy- phenyl)-4-(methyla...)
Show SMILES CNc1nc(=O)n(-c2cc(O)cc(F)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H11ClFN3O2/c1-18-14-12-3-2-8(16)4-13(12)20(15(22)19-14)10-5-9(17)6-11(21)7-10/h2-7,21H,1H3,(H,18,19,22)
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507726
PNG
(7-chloro-4-(cyclopropylmethylamino)- 1-(3-fluoroph...)
Show SMILES CN(C1CC1)c1nc(=O)n(-c2cccc(F)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H15ClFN3O/c1-22(13-6-7-13)17-15-8-5-11(19)9-16(15)23(18(24)21-17)14-4-2-3-12(20)10-14/h2-5,8-10,13H,6-7H2,1H3
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507727
PNG
(7-chloro-4-(dimethylamino)-1-(3-(2- phenoxyethyl)p...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(CCOc3ccccc3)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C24H22ClN3O2/c1-27(2)23-21-12-11-18(25)16-22(21)28(24(29)26-23)19-8-6-7-17(15-19)13-14-30-20-9-4-3-5-10-20/h3-12,15-16H,13-14H2,1-2H3
PDB

UniProtKB/SwissProt
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UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507728
PNG
(7-chloro-6-fluoro-4-(methylamino)-1- phenyl-quinaz...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)c(F)cc12
Show InChI InChI=1S/C15H11ClFN3O/c1-18-14-10-7-12(17)11(16)8-13(10)20(15(21)19-14)9-5-3-2-4-6-9/h2-8H,1H3,(H,18,19,21)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507730
PNG
(4-(dimethylamino)-7-chloro-1-(3- methoxyphenyphydr...)
Show SMILES COc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N(C)C
Show InChI InChI=1S/C17H16ClN3O2/c1-20(2)16-14-8-7-11(18)9-15(14)21(17(22)19-16)12-5-4-6-13(10-12)23-3/h4-10H,1-3H3
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507731
PNG
(7-chloro-5-fluoro-4-(methylamino)-1- phenyl-quinaz...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Cl)cc(F)c12
Show InChI InChI=1S/C15H11ClFN3O/c1-18-14-13-11(17)7-9(16)8-12(13)20(15(21)19-14)10-5-3-2-4-6-10/h2-8H,1H3,(H,18,19,21)
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507733
PNG
(4-(dimethylamino)-7-chloro-1-[3- (hydroxymethyl)ph...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(CO)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H16ClN3O2/c1-20(2)16-14-7-6-12(18)9-15(14)21(17(23)19-16)13-5-3-4-11(8-13)10-22/h3-9,22H,10H2,1-2H3
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507735
PNG
(7-methyl-4-(methylamino)-1-phenyl- quinazolin-2(1H...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(C)ccc12
Show InChI InChI=1S/C16H15N3O/c1-11-8-9-13-14(10-11)19(12-6-4-3-5-7-12)16(20)18-15(13)17-2/h3-10H,1-2H3,(H,17,18,20)
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507736
PNG
((R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenyl...)
Show SMILES F[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H15ClFN3O/c19-12-6-7-15-16(10-12)23(14-4-2-1-3-5-14)18(24)21-17(15)22-9-8-13(20)11-22/h1-7,10,13H,8-9,11H2/t13-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507738
PNG
(7-cyclopropyl-4-(methylamino)-1- phenylquinazolin-...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C18H17N3O/c1-19-17-15-10-9-13(12-7-8-12)11-16(15)21(18(22)20-17)14-5-3-2-4-6-14/h2-6,9-12H,7-8H2,1H3,(H,19,20,22)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507739
PNG
(3-[4-(dimethylamino)-7-chloro-2- oxohydroquinazoli...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(c2)C#N)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H13ClN4O/c1-21(2)16-14-7-6-12(18)9-15(14)22(17(23)20-16)13-5-3-4-11(8-13)10-19/h3-9H,1-2H3
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507740
PNG
(7-chloro-4-(methylamino)-1-pyrimidin- 2-yl-quinazo...)
Show SMILES CNc1nc(=O)n(-c2ncccn2)c2cc(Cl)ccc12
Show InChI InChI=1S/C13H10ClN5O/c1-15-11-9-4-3-8(14)7-10(9)19(13(20)18-11)12-16-5-2-6-17-12/h2-7H,1H3,(H,15,18,20)
PDB

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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507741
PNG
(7-chloro-1-(3-hydroxyphenyl)-4- (methylamino)-hydr...)
Show SMILES CNc1nc(=O)n(-c2cccc(O)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H12ClN3O2/c1-17-14-12-6-5-9(16)7-13(12)19(15(21)18-14)10-3-2-4-11(20)8-10/h2-8,20H,1H3,(H,17,18,21)
PDB

UniProtKB/SwissProt
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UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507742
PNG
(1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroq...)
Show SMILES Fc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CC(C1)C#N
Show InChI InChI=1S/C18H12ClFN4O/c19-12-4-5-15-16(6-12)24(14-3-1-2-13(20)7-14)18(25)22-17(15)23-9-11(8-21)10-23/h1-7,11H,9-10H2
PDB

UniProtKB/SwissProt
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GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507744
PNG
(7-chloro-1-[3-(2-hydroxyethyl)phenyl]- 4-(methylam...)
Show SMILES CNc1nc(=O)n(-c2cccc(CCO)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H16ClN3O2/c1-19-16-14-6-5-12(18)10-15(14)21(17(23)20-16)13-4-2-3-11(9-13)7-8-22/h2-6,9-10,22H,7-8H2,1H3,(H,19,20,23)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507745
PNG
(7-chloro-4-(methylamino)-1- (pyrimidin-5-yl)-quina...)
Show SMILES CNc1nc(=O)n(-c2cncnc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C13H10ClN5O/c1-15-12-10-3-2-8(14)4-11(10)19(13(20)18-12)9-5-16-7-17-6-9/h2-7H,1H3,(H,15,18,20)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507746
PNG
(7-chloro-1-[3-(3-hydroxypropyl)- phenyl]-4-(methyl...)
Show SMILES CNc1nc(=O)n(-c2cccc(CCCO)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H18ClN3O2/c1-20-17-15-8-7-13(19)11-16(15)22(18(24)21-17)14-6-2-4-12(10-14)5-3-9-23/h2,4,6-8,10-11,23H,3,5,9H2,1H3,(H,20,21,24)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507747
PNG
(7-chloro-4-(methylamino)-1-(1 H- pyrazol-4-yl)-qui...)
Show SMILES CNc1nc(=O)n(-c2cn[nH]c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C12H10ClN5O/c1-14-11-9-3-2-7(13)4-10(9)18(12(19)17-11)8-5-15-16-6-8/h2-6H,1H3,(H,15,16)(H,14,17,19)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507748
PNG
(7-methoxy-4-(methylamino)-1-phenyl- quinazolin-2(1...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(OC)ccc12
Show InChI InChI=1S/C16H15N3O2/c1-17-15-13-9-8-12(21-2)10-14(13)19(16(20)18-15)11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,20)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507749
PNG
(7-chloro-4-(methylamino)-1-(thiazol-2- yl)-quinazo...)
Show SMILES CNc1nc(=O)n(-c2nccs2)c2cc(Cl)ccc12
Show InChI InChI=1S/C12H9ClN4OS/c1-14-10-8-3-2-7(13)6-9(8)17(11(18)16-10)12-15-4-5-19-12/h2-6H,1H3,(H,14,16,18)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507750
PNG
(4-(methylamino)-2-oxo-1-phenyl-1,2- dihydro-quinaz...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C#N
Show InChI InChI=1S/C16H12N4O/c1-18-15-13-8-7-11(10-17)9-14(13)20(16(21)19-15)12-5-3-2-4-6-12/h2-9H,1H3,(H,18,19,21)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507752
PNG
(7-chloro-4-(methylamino)-1-(thiazol-5- yl)-quinazo...)
Show SMILES CNc1nc(=O)n(-c2cncs2)c2cc(Cl)ccc12
Show InChI InChI=1S/C12H9ClN4OS/c1-14-11-8-3-2-7(13)4-9(8)17(12(18)16-11)10-5-15-6-19-10/h2-6H,1H3,(H,14,16,18)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507753
PNG
(4-(methylamino)-1-phenyl-7-(trifluoro- methyl)-qui...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H12F3N3O/c1-20-14-12-8-7-10(16(17,18)19)9-13(12)22(15(23)21-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,20,21,23)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507757
PNG
(N-(3-(7-chloro-4-(dimethylamino)-2- oxoquinazolin-...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(NS(C)(=O)=O)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H17ClN4O3S/c1-21(2)16-14-8-7-11(18)9-15(14)22(17(23)19-16)13-6-4-5-12(10-13)20-26(3,24)25/h4-10,20H,1-3H3
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507759
PNG
(4-(dimethylamino)-7-chloro-1-(3- hydroxyphenyphydr...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(O)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H14ClN3O2/c1-19(2)15-13-7-6-10(17)8-14(13)20(16(22)18-15)11-4-3-5-12(21)9-11/h3-9,21H,1-2H3
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507761
PNG
(7-Chloro-4-(methylamino)-1-(3- methylphenyphydroqu...)
Show SMILES CNc1nc(=O)n(-c2cccc(C)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H14ClN3O/c1-10-4-3-5-12(8-10)20-14-9-11(17)6-7-13(14)15(18-2)19-16(20)21/h3-9H,1-2H3,(H,18,19,21)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507762
PNG
(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Show SMILES CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H14ClN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507763
PNG
(7-Chloro-1-(3-chlorophenyl)-4- (methylamino)hydroq...)
Show SMILES CNc1nc(=O)n(-c2cccc(Cl)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H11Cl2N3O/c1-18-14-12-6-5-10(17)8-13(12)20(15(21)19-14)11-4-2-3-9(16)7-11/h2-8H,1H3,(H,18,19,21)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507764
PNG
(4-(azetidin-1-yl)-7-chloro-1-phenyl- quinazolin-2(...)
Show SMILES Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCC1
Show InChI InChI=1S/C17H14ClN3O/c18-12-7-8-14-15(11-12)21(13-5-2-1-3-6-13)17(22)19-16(14)20-9-4-10-20/h1-3,5-8,11H,4,9-10H2
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507765
PNG
(7-chloro-1-(2-fluorophenyl)-4- (methylamino)quinaz...)
Show SMILES CNc1nc(=O)n(-c2ccccc2F)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H11ClFN3O/c1-18-14-10-7-6-9(16)8-13(10)20(15(21)19-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,18,19,21)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507766
PNG
((S)-7-chloro-4-(3-hydroxypyrrolidin-1- yl)-1-pheny...)
Show SMILES O[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(23)11-21/h1-7,10,14,23H,8-9,11H2/t14-/m0/s1
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507767
PNG
(4-amino-7-chloro-1-phenylquinazolin- 2(1H)-one | U...)
Show SMILES Nc1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C14H10ClN3O/c15-9-6-7-11-12(8-9)18(14(19)17-13(11)16)10-4-2-1-3-5-10/h1-8H,(H2,16,17,19)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507769
PNG
(1-(3-bromophenyl)-7-chloro-4- (dimethylamino)quina...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(Br)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H13BrClN3O/c1-20(2)15-13-7-6-11(18)9-14(13)21(16(22)19-15)12-5-3-4-10(17)8-12/h3-9H,1-2H3
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507771
PNG
(7-chloro-1-(3-fluorophenyl)-4- (methylamino)quinaz...)
Show SMILES CNc1nc(=O)n(-c2cccc(F)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H11ClFN3O/c1-18-14-12-6-5-9(16)7-13(12)20(15(21)19-14)11-4-2-3-10(17)8-11/h2-8H,1H3,(H,18,19,21)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507778
PNG
(7-bromo-4-(dimethylamino)-1-phenyl- quinazolin-2(1...)
Show SMILES CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12
Show InChI InChI=1S/C16H14BrN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507779
PNG
(7-chloro-1-phenyl-4-(piperidin-1-yl)- quinazolin-2...)
Show SMILES Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCCCC1
Show InChI InChI=1S/C19H18ClN3O/c20-14-9-10-16-17(13-14)23(15-7-3-1-4-8-15)19(24)21-18(16)22-11-5-2-6-12-22/h1,3-4,7-10,13H,2,5-6,11-12H2
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507780
PNG
(4-(dimethylamino)-7-fluoro-1-phenyl- quinazolin-2(...)
Show SMILES CN(C)c1nc(=O)n(-c2ccccc2)c2cc(F)ccc12
Show InChI InChI=1S/C16H14FN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507781
PNG
(7-chloro-1-phenyl-4-(pyrrolidin-1-yl)- quinazolin-...)
Show SMILES Clc1ccc2c(nc(=O)n(-c3ccccc3)c2c1)N1CCCC1
Show InChI InChI=1S/C18H16ClN3O/c19-13-8-9-15-16(12-13)22(14-6-2-1-3-7-14)18(23)20-17(15)21-10-4-5-11-21/h1-3,6-9,12H,4-5,10-11H2
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507783
PNG
((S)-7-chloro-4-(3-methoxypyrrolidin-1- yl)-1-pheny...)
Show SMILES CO[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H18ClN3O2/c1-25-15-9-10-22(12-15)18-16-8-7-13(20)11-17(16)23(19(24)21-18)14-5-3-2-4-6-14/h2-8,11,15H,9-10,12H2,1H3/t15-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507784
PNG
(1-(2-chlorophenyl)-6-fluoro-4-(methyl- amino)-7-(t...)
Show SMILES CNc1nc(=O)n(-c2ccccc2Cl)c2cc(c(F)cc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4N3O/c1-22-14-8-6-11(18)9(16(19,20)21)7-13(8)24(15(25)23-14)12-5-3-2-4-10(12)17/h2-7H,1H3,(H,22,23,25)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507785
PNG
(7-bromo-6-chloro-1-(2-chlorophenyl)- 4-(isoxazol-4...)
Show SMILES Clc1cc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2cc1Br
Show InChI InChI=1S/C17H9BrCl2N4O2/c18-11-6-15-10(5-13(11)20)16(22-9-7-21-26-8-9)23-17(25)24(15)14-4-2-1-3-12(14)19/h1-8H,(H,22,23,25)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507787
PNG
(7-chloro-4-[methylbenzylamino]-1- phenylhydroquina...)
Show SMILES CN(Cc1ccccc1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H18ClN3O/c1-25(15-16-8-4-2-5-9-16)21-19-13-12-17(23)14-20(19)26(22(27)24-21)18-10-6-3-7-11-18/h2-14H,15H2,1H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
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