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Compile Data Set for Download or QSAR

Found 46 hits of affinity data for UniProtKB/TrEMBL: P18848   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524158
PNG
(US11166942, Compound 60)
Show SMILES O[C@@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C24H24Cl2FN3O3/c25-19-4-3-16-11-18(2-1-17(16)12-19)24(32)28-30-9-7-29(8-10-30)14-20(31)15-33-21-5-6-22(26)23(27)13-21/h1-6,11-13,20,31H,7-10,14-15H2,(H,28,32)/t20-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524152
PNG
(US11166942, Compound 54)
Show SMILES O[C@H](CNC1CCN(CC1)NC(=O)c1cc2cc(Cl)ccc2o1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H24Cl2FN3O4/c24-15-1-4-21-14(9-15)10-22(33-21)23(31)28-29-7-5-16(6-8-29)27-12-17(30)13-32-18-2-3-19(25)20(26)11-18/h1-4,9-11,16-17,27,30H,5-8,12-13H2,(H,28,31)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524148
PNG
(US11166942, Compound 50)
Show SMILES O[C@@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C21H23Cl2F2N3O4/c22-17-3-1-15(9-19(17)24)31-12-14(29)11-27-5-7-28(8-6-27)26-21(30)13-32-16-2-4-18(23)20(25)10-16/h1-4,9-10,14,29H,5-8,11-13H2,(H,26,30)/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.93n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524138
PNG
(US11166942, Compound 31 | US11166942, Compound 47)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)C2CNc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H23Cl2FN4O4/c23-13-1-4-19-18(9-13)26-11-20(33-19)22(31)28-29-7-5-14(6-8-29)27-21(30)12-32-15-2-3-16(24)17(25)10-15/h1-4,9-10,14,20,26H,5-8,11-12H2,(H,27,30)(H,28,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.98n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524143
PNG
(US11166942, Compound 45)
Show SMILES Clc1ccc(OCC(=O)NC2CCN(CC2)NC(=O)COc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C21H23Cl2N3O4/c22-15-1-5-18(6-2-15)29-13-20(27)24-17-9-11-26(12-10-17)25-21(28)14-30-19-7-3-16(23)4-8-19/h1-8,17H,9-14H2,(H,24,27)(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524115
PNG
(US11166942, Compound 4)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)COc2ccc(Cl)c(F)c2)ccc1Cl
Show InChI InChI=1S/C21H21Cl2F2N3O4/c22-16-3-1-14(9-18(16)24)31-11-20(29)26-13-5-7-28(8-6-13)27-21(30)12-32-15-2-4-17(23)19(25)10-15/h1-4,9-10,13H,5-8,11-12H2,(H,26,29)(H,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524146
PNG
(US11166942, Compound 48)
Show SMILES O[C@@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1cc2cc(Cl)ccc2o1
Show InChI InChI=1S/C22H22Cl2FN3O4/c23-15-1-4-20-14(9-15)10-21(32-20)22(30)26-28-7-5-27(6-8-28)12-16(29)13-31-17-2-3-18(24)19(25)11-17/h1-4,9-11,16,29H,5-8,12-13H2,(H,26,30)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.36n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524144
PNG
(US11166942, Compound 46)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)[C@H]2CNc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H23Cl2FN4O4/c23-13-1-4-19-18(9-13)26-11-20(33-19)22(31)28-29-7-5-14(6-8-29)27-21(30)12-32-15-2-3-16(24)17(25)10-15/h1-4,9-10,14,20,26H,5-8,11-12H2,(H,27,30)(H,28,31)/t20-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524106
PNG
(US11166942, Compound 1)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)c2ccc3cc(Cl)ccc3n2)ccc1Cl
Show InChI InChI=1S/C23H21Cl2FN4O3/c24-15-2-6-20-14(11-15)1-5-21(28-20)23(32)29-30-9-7-16(8-10-30)27-22(31)13-33-17-3-4-18(25)19(26)12-17/h1-6,11-12,16H,7-10,13H2,(H,27,31)(H,29,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524138
PNG
(US11166942, Compound 31 | US11166942, Compound 47)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)C2CNc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H23Cl2FN4O4/c23-13-1-4-19-18(9-13)26-11-20(33-19)22(31)28-29-7-5-14(6-8-29)27-21(30)12-32-15-2-3-16(24)17(25)10-15/h1-4,9-10,14,20,26H,5-8,11-12H2,(H,27,30)(H,28,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.16n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524156
PNG
(US11166942, Compound 58)
Show SMILES O[C@@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2n1
Show InChI InChI=1S/C23H23Cl2FN4O3/c24-16-2-6-21-15(11-16)1-5-22(27-21)23(32)28-30-9-7-29(8-10-30)13-17(31)14-33-18-3-4-19(25)20(26)12-18/h1-6,11-12,17,31H,7-10,13-14H2,(H,28,32)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524125
PNG
(US11166942, Compound 14)
Show SMILES OC(COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C24H24Cl2FN3O3/c25-19-4-3-16-11-18(2-1-17(16)12-19)24(32)28-30-9-7-29(8-10-30)14-20(31)15-33-21-5-6-22(26)23(27)13-21/h1-6,11-13,20,31H,7-10,14-15H2,(H,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.2n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524133
PNG
(US11166942, Compound 22)
Show SMILES Fc1cc(OCCNC2CCN(CC2)NC(=O)COc2ccc(Cl)c(F)c2)ccc1Cl
Show InChI InChI=1S/C21H23Cl2F2N3O3/c22-17-3-1-15(11-19(17)24)30-10-7-26-14-5-8-28(9-6-14)27-21(29)13-31-16-2-4-18(23)20(25)12-16/h1-4,11-12,14,26H,5-10,13H2,(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524114
PNG
(US11166942, Compound 3)
Show SMILES Fc1cc(OCC(=O)NN2CCC(CC2)NC(=O)c2ccc3cc(Cl)ccc3n2)ccc1Cl
Show InChI InChI=1S/C23H21Cl2FN4O3/c24-15-2-6-20-14(11-15)1-5-21(28-20)23(32)27-16-7-9-30(10-8-16)29-22(31)13-33-17-3-4-18(25)19(26)12-17/h1-6,11-12,16H,7-10,13H2,(H,27,32)(H,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.6n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524130
PNG
(US11166942, Compound 19)
Show SMILES OC(COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1cc2cc(Cl)ccc2o1
Show InChI InChI=1S/C22H22Cl2FN3O4/c23-15-1-4-20-14(9-15)10-21(32-20)22(30)26-28-7-5-27(6-8-28)12-16(29)13-31-17-2-3-18(24)19(25)11-17/h1-4,9-11,16,29H,5-8,12-13H2,(H,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.5n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524139
PNG
(US11166942, Compound 32)
Show SMILES Fc1cc(OCC(=O)NN2CCC(CC2)NC(=O)C2CNc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H23Cl2FN4O4/c23-13-1-4-19-18(9-13)26-11-20(33-19)22(31)27-14-5-7-29(8-6-14)28-21(30)12-32-15-2-3-16(24)17(25)10-15/h1-4,9-10,14,20,26H,5-8,11-12H2,(H,27,31)(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524126
PNG
(US11166942, Compound 15)
Show SMILES OC(COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2n1
Show InChI InChI=1S/C23H23Cl2FN4O3/c24-16-2-6-21-15(11-16)1-5-22(27-21)23(32)28-30-9-7-29(8-10-30)13-17(31)14-33-18-3-4-19(25)20(26)12-18/h1-6,11-12,17,31H,7-10,13-14H2,(H,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.4n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524113
PNG
(US11166942, Compound 2)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)c2cc3cc(Cl)ccc3o2)ccc1Cl
Show InChI InChI=1S/C22H20Cl2FN3O4/c23-14-1-4-19-13(9-14)10-20(32-19)22(30)27-28-7-5-15(6-8-28)26-21(29)12-31-16-2-3-17(24)18(25)11-16/h1-4,9-11,15H,5-8,12H2,(H,26,29)(H,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.4n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524116
PNG
(US11166942, Compound 5)
Show SMILES Fc1cc(OCC(=O)NN2CCC(CC2)NC(=O)c2cc3cc(Cl)ccc3o2)ccc1Cl
Show InChI InChI=1S/C22H20Cl2FN3O4/c23-14-1-4-19-13(9-14)10-20(32-19)22(30)26-15-5-7-28(8-6-15)27-21(29)12-31-16-2-3-17(24)18(25)11-16/h1-4,9-11,15H,5-8,12H2,(H,26,30)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.8n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524149
PNG
(US11166942, Compound 51)
Show SMILES O[C@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C21H23Cl2F2N3O4/c22-17-3-1-15(9-19(17)24)31-12-14(29)11-27-5-7-28(8-6-27)26-21(30)13-32-16-2-4-18(23)20(25)10-16/h1-4,9-10,14,29H,5-8,11-13H2,(H,26,30)/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.8n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524150
PNG
(US11166942, Compound 52)
Show SMILES O[C@H](CNC1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C22H25Cl2F2N3O4/c23-18-3-1-16(9-20(18)25)32-12-15(30)11-27-14-5-7-29(8-6-14)28-22(31)13-33-17-2-4-19(24)21(26)10-17/h1-4,9-10,14-15,27,30H,5-8,11-13H2,(H,28,31)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26.9n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524159
PNG
(US11166942, Compound 61)
Show SMILES O[C@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C24H24Cl2FN3O3/c25-19-4-3-16-11-18(2-1-17(16)12-19)24(32)28-30-9-7-29(8-10-30)14-20(31)15-33-21-5-6-22(26)23(27)13-21/h1-6,11-13,20,31H,7-10,14-15H2,(H,28,32)/t20-/m0/s1
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n/an/a 29.4n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524117
PNG
(US11166942, Compound 6)
Show SMILES OC(COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C21H23Cl2F2N3O4/c22-17-3-1-15(9-19(17)24)31-12-14(29)11-27-5-7-28(8-6-27)26-21(30)13-32-16-2-4-18(23)20(25)10-16/h1-4,9-10,14,29H,5-8,11-13H2,(H,26,30)
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n/an/a 30.8n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524135
PNG
(US11166942, Compound 24)
Show SMILES Fc1cc(OCCNC2CCN(CC2)NC(=O)c2cc3cc(Cl)ccc3o2)ccc1Cl
Show InChI InChI=1S/C22H22Cl2FN3O3/c23-15-1-4-20-14(11-15)12-21(31-20)22(29)27-28-8-5-16(6-9-28)26-7-10-30-17-2-3-18(24)19(25)13-17/h1-4,11-13,16,26H,5-10H2,(H,27,29)
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n/an/a 32.2n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524134
PNG
(US11166942, Compound 23)
Show SMILES Fc1cc(OCCNC2CCN(CC2)NC(=O)c2ccc3cc(Cl)ccc3n2)ccc1Cl
Show InChI InChI=1S/C23H23Cl2FN4O2/c24-16-2-6-21-15(13-16)1-5-22(28-21)23(31)29-30-10-7-17(8-11-30)27-9-12-32-18-3-4-19(25)20(26)14-18/h1-6,13-14,17,27H,7-12H2,(H,29,31)
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n/an/a 55.6n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524132
PNG
(US11166942, Compound 21)
Show SMILES OC(CNC1CCN(CC1)NC(=O)c1cc2C=C(Cl)CCc2o1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H26Cl2FN3O4/c24-15-1-4-21-14(9-15)10-22(33-21)23(31)28-29-7-5-16(6-8-29)27-12-17(30)13-32-18-2-3-19(25)20(26)11-18/h2-3,9-11,16-17,27,30H,1,4-8,12-13H2,(H,28,31)
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n/an/a 61.9n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524147
PNG
(US11166942, Compound 49)
Show SMILES O[C@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1cc2cc(Cl)ccc2o1
Show InChI InChI=1S/C22H22Cl2FN3O4/c23-15-1-4-20-14(9-15)10-21(32-20)22(30)26-28-7-5-27(6-8-28)12-16(29)13-31-17-2-3-18(24)19(25)11-17/h1-4,9-11,16,29H,5-8,12-13H2,(H,26,30)/t16-/m0/s1
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n/an/a 69.7n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524154
PNG
(US11166942, Compound 56)
Show SMILES O[C@H](CNC1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2n1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C24H25Cl2FN4O3/c25-16-2-6-22-15(11-16)1-5-23(29-22)24(33)30-31-9-7-17(8-10-31)28-13-18(32)14-34-19-3-4-20(26)21(27)12-19/h1-6,11-12,17-18,28,32H,7-10,13-14H2,(H,30,33)/t18-/m1/s1
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n/an/a 71.7n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524129
PNG
(US11166942, Compound 18)
Show SMILES Fc1cc(OCCCN2CCN(CC2)NC(=O)c2cc3cc(Cl)ccc3o2)ccc1Cl
Show InChI InChI=1S/C22H22Cl2FN3O3/c23-16-2-5-20-15(12-16)13-21(31-20)22(29)26-28-9-7-27(8-10-28)6-1-11-30-17-3-4-18(24)19(25)14-17/h2-5,12-14H,1,6-11H2,(H,26,29)
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n/an/a 76.3n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524128
PNG
(US11166942, Compound 17)
Show SMILES Fc1cc(OCCCN2CCN(CC2)NC(=O)c2ccc3cc(Cl)ccc3n2)ccc1Cl
Show InChI InChI=1S/C23H23Cl2FN4O2/c24-17-3-7-21-16(14-17)2-6-22(27-21)23(31)28-30-11-9-29(10-12-30)8-1-13-32-18-4-5-19(25)20(26)15-18/h2-7,14-15H,1,8-13H2,(H,28,31)
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n/an/a 79.1n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524141
PNG
(US11166942, Compound 39)
Show SMILES [O-][N+](=O)c1cc(OCC(=O)NC2CCN(CC2)NC(=O)COc2ccc(Cl)c(F)c2)ccc1Cl
Show InChI InChI=1S/C21H21Cl2FN4O6/c22-16-3-1-14(9-18(16)24)34-12-21(30)26-27-7-5-13(6-8-27)25-20(29)11-33-15-2-4-17(23)19(10-15)28(31)32/h1-4,9-10,13H,5-8,11-12H2,(H,25,29)(H,26,30)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524140
PNG
(US11166942, Compound 35)
Show SMILES FC(F)(F)c1ccc(OCC(=O)NC2CCN(CC2)NC(=O)COc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H23F6N3O4/c24-22(25,26)15-1-5-18(6-2-15)35-13-20(33)30-17-9-11-32(12-10-17)31-21(34)14-36-19-7-3-16(4-8-19)23(27,28)29/h1-8,17H,9-14H2,(H,30,33)(H,31,34)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524124
PNG
(US11166942, Compound 13)
Show SMILES OC(COc1ccc(Cl)c(F)c1)NN1CCN(CC1)NC(=O)C1Cc2cc(Cl)ccc2O1
Show InChI InChI=1S/C21H23Cl2FN4O4/c22-14-1-4-18-13(9-14)10-19(32-18)21(30)26-28-7-5-27(6-8-28)25-20(29)12-31-15-2-3-16(23)17(24)11-15/h1-4,9,11,19-20,25,29H,5-8,10,12H2,(H,26,30)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524123
PNG
(US11166942, Compound 12)
Show SMILES Fc1cc(OCC(=O)NN2CCC(CC2)NC(=O)C2Cc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H22Cl2FN3O4/c23-14-1-4-19-13(9-14)10-20(32-19)22(30)26-15-5-7-28(8-6-15)27-21(29)12-31-16-2-3-17(24)18(25)11-16/h1-4,9,11,15,20H,5-8,10,12H2,(H,26,30)(H,27,29)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524122
PNG
(US11166942, Compound 11)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)C2Cc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H22Cl2FN3O4/c23-14-1-4-19-13(9-14)10-20(32-19)22(30)27-28-7-5-15(6-8-28)26-21(29)12-31-16-2-3-17(24)18(25)11-16/h1-4,9,11,15,20H,5-8,10,12H2,(H,26,29)(H,27,30)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524121
PNG
(US11166942, Compound 10)
Show SMILES Fc1cc(OCC(=O)NN2CCC(CC2)NC(=O)c2nc3cc(Cl)ccc3s2)ccc1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3S/c22-12-1-4-18-17(9-12)26-21(32-18)20(30)25-13-5-7-28(8-6-13)27-19(29)11-31-14-2-3-15(23)16(24)10-14/h1-4,9-10,13H,5-8,11H2,(H,25,30)(H,27,29)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524120
PNG
(US11166942, Compound 9)
Show SMILES Fc1cc(OCC(=O)NC2CCN(CC2)NC(=O)c2nc3cc(Cl)ccc3s2)ccc1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3S/c22-12-1-4-18-17(9-12)26-21(32-18)20(30)27-28-7-5-13(6-8-28)25-19(29)11-31-14-2-3-15(23)16(24)10-14/h1-4,9-10,13H,5-8,11H2,(H,25,29)(H,27,30)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524160
PNG
(US11166942, Compound 62)
Show SMILES O[C@@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H22ClF4N3O4/c22-18-6-5-17(11-19(18)23)32-13-15(30)12-28-7-9-29(10-8-28)27-20(31)14-1-3-16(4-2-14)33-21(24,25)26/h1-6,11,15,30H,7-10,12-13H2,(H,27,31)/t15-/m1/s1
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524167
PNG
(US11166942, Compound 71)
Show SMILES OC(COc1ccc(cc1)C(F)(F)F)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2n1
Show InChI InChI=1S/C24H24ClF3N4O3/c25-18-4-8-21-16(13-18)1-7-22(29-21)23(34)30-32-11-9-31(10-12-32)14-19(33)15-35-20-5-2-17(3-6-20)24(26,27)28/h1-8,13,19,33H,9-12,14-15H2,(H,30,34)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524153
PNG
(US11166942, Compound 55)
Show SMILES O[C@@H](CNC1CCN(CC1)NC(=O)c1cc2cc(Cl)ccc2o1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H24Cl2FN3O4/c24-15-1-4-21-14(9-15)10-22(33-21)23(31)28-29-7-5-16(6-8-29)27-12-17(30)13-32-18-2-3-19(25)20(26)11-18/h1-4,9-11,16-17,27,30H,5-8,12-13H2,(H,28,31)/t17-/m0/s1
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n/an/a 102n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524127
PNG
(US11166942, Compound 16)
Show SMILES Fc1cc(OCCCN2CCN(CC2)NC(=O)COc2ccc(Cl)c(F)c2)ccc1Cl
Show InChI InChI=1S/C21H23Cl2F2N3O3/c22-17-4-2-15(12-19(17)24)30-11-1-6-27-7-9-28(10-8-27)26-21(29)14-31-16-3-5-18(23)20(25)13-16/h2-5,12-13H,1,6-11,14H2,(H,26,29)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524142
PNG
(US11166942, Compound 44)
Show SMILES Fc1cc(OCCCN2CCN(CC2)NC(=O)C2CNc3cc(Cl)ccc3O2)ccc1Cl
Show InChI InChI=1S/C22H25Cl2FN4O3/c23-15-2-5-20-19(12-15)26-14-21(32-20)22(30)27-29-9-7-28(8-10-29)6-1-11-31-16-3-4-17(24)18(25)13-16/h2-5,12-13,21,26H,1,6-11,14H2,(H,27,30)
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n/an/a 151n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524119
PNG
(US11166942, Compound 8)
Show SMILES OC(CNC1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C22H25Cl2F2N3O4/c23-18-3-1-16(9-20(18)25)32-12-15(30)11-27-14-5-7-29(8-6-14)28-22(31)13-33-17-2-4-19(24)21(26)10-17/h1-4,9-10,14-15,27,30H,5-8,11-13H2,(H,28,31)
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PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524137
PNG
(US11166942, Compound 30)
Show SMILES Fc1cc(OCC(=O)NN2CCN(CC2)C(=O)COc2ccc(Cl)c(F)c2)ccc1Cl
Show InChI InChI=1S/C20H19Cl2F2N3O4/c21-15-3-1-13(9-17(15)23)30-11-19(28)25-27-7-5-26(6-8-27)20(29)12-31-14-2-4-16(22)18(24)10-14/h1-4,9-10H,5-8,11-12H2,(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 187n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524151
PNG
(US11166942, Compound 53)
Show SMILES O[C@@H](CNC1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1)COc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C22H25Cl2F2N3O4/c23-18-3-1-16(9-20(18)25)32-12-15(30)11-27-14-5-7-29(8-6-14)28-22(31)13-33-17-2-4-19(24)21(26)10-17/h1-4,9-10,14-15,27,30H,5-8,11-13H2,(H,28,31)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 268n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair
Cyclic AMP-dependent transcription factor ATF-4


(Human)
BDBM524157
PNG
(US11166942, Compound 59)
Show SMILES O[C@H](COc1ccc(Cl)c(F)c1)CN1CCN(CC1)NC(=O)c1ccc2cc(Cl)ccc2n1
Show InChI InChI=1S/C23H23Cl2FN4O3/c24-16-2-6-21-15(11-16)1-5-22(27-21)23(32)28-30-9-7-29(8-10-30)13-17(31)14-33-18-3-4-19(25)20(26)12-18/h1-6,11-12,17,31H,7-10,13-14H2,(H,28,32)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 570n/an/an/an/an/an/a



PRAXIS BIOTECH LLC

US Patent


Assay Description
The ATF4 reporter was prepared by fusing the human full length 5′UTR of ATF4 (NCBI Accession No. BC022088.2) upstream of the firefly luciferase...


US Patent US11166942 (2021)

More data for this
Ligand-Target Pair