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Compile Data Set for Download or QSAR

Found 183 hits of affinity data for UniProtKB/TrEMBL: Q6UWP7   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysocardiolipin acyltransferase 1


(Human)
BDBM532078
PNG
(US11208404, Compound 222)
Show SMILES CCOc1ccc(CC)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H20FN3O4/c1-3-14-7-10-19(29-4-2)16(12-14)21(28)25-18-13-15(8-9-17(18)24)22-26-27-23(31-22)20-6-5-11-30-20/h5-13H,3-4H2,1-2H3,(H,25,28)
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US Patent
n/an/a 8n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532078
PNG
(US11208404, Compound 222)
Show SMILES CCOc1ccc(CC)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H20FN3O4/c1-3-14-7-10-19(29-4-2)16(12-14)21(28)25-18-13-15(8-9-17(18)24)22-26-27-23(31-22)20-6-5-11-30-20/h5-13H,3-4H2,1-2H3,(H,25,28)
UniProtKB/SwissProt

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n/an/a<10n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532078
PNG
(US11208404, Compound 222)
Show SMILES CCOc1ccc(CC)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H20FN3O4/c1-3-14-7-10-19(29-4-2)16(12-14)21(28)25-18-13-15(8-9-17(18)24)22-26-27-23(31-22)20-6-5-11-30-20/h5-13H,3-4H2,1-2H3,(H,25,28)
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US Patent
n/an/a<10n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532078
PNG
(US11208404, Compound 222)
Show SMILES CCOc1ccc(CC)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H20FN3O4/c1-3-14-7-10-19(29-4-2)16(12-14)21(28)25-18-13-15(8-9-17(18)24)22-26-27-23(31-22)20-6-5-11-30-20/h5-13H,3-4H2,1-2H3,(H,25,28)
UniProtKB/SwissProt

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US Patent
n/an/a<10n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532067
PNG
(US11208404, Compound 184)
Show SMILES COc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H13ClFN3O4/c1-27-16-7-5-12(21)10-13(16)18(26)23-15-9-11(4-6-14(15)22)19-24-25-20(29-19)17-3-2-8-28-17/h2-10H,1H3,(H,23,26)
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US Patent
n/an/a 18n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532098
PNG
(US11208404, Compound 405)
Show SMILES COc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H13F4N3O5/c1-30-16-7-5-12(33-21(23,24)25)10-13(16)18(29)26-15-9-11(4-6-14(15)22)19-27-28-20(32-19)17-3-2-8-31-17/h2-10H,1H3,(H,26,29)
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n/an/a 19n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532068
PNG
(US11208404, Compound 216)
Show SMILES CCOc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H15ClFN3O4/c1-2-28-17-8-6-13(22)11-14(17)19(27)24-16-10-12(5-7-15(16)23)20-25-26-21(30-20)18-4-3-9-29-18/h3-11H,2H2,1H3,(H,24,27)
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n/an/a 19n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532103
PNG
(US11208404, Compound 416)
Show SMILES COc1ccc(cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N3O4/c1-30-16-7-5-12(21(23,24)25)10-13(16)18(29)26-15-9-11(4-6-14(15)22)19-27-28-20(32-19)17-3-2-8-31-17/h2-10H,1H3,(H,26,29)
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n/an/a 19n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532086
PNG
(US11208404, Compound 317)
Show SMILES FC(F)COc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H13ClF3N3O4/c22-12-4-6-16(31-10-18(24)25)13(9-12)19(29)26-15-8-11(3-5-14(15)23)20-27-28-21(32-20)17-2-1-7-30-17/h1-9,18H,10H2,(H,26,29)
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n/an/a 19n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532095
PNG
(US11208404, Compound 306)
Show SMILES C[F]Oc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H13ClF2N3O4/c1-23-30-16-7-5-12(21)10-13(16)18(27)24-15-9-11(4-6-14(15)22)19-25-26-20(29-19)17-3-2-8-28-17/h2-10H,1H3,(H,24,27)
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n/an/a 19n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532093
PNG
(US11208404, Compound 304)
Show SMILES Fc1ccc(cc1NC(=O)c1cc(Cl)ccc1OC(F)(F)F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H10ClF4N3O4/c21-11-4-6-15(32-20(23,24)25)12(9-11)17(29)26-14-8-10(3-5-13(14)22)18-27-28-19(31-18)16-2-1-7-30-16/h1-9H,(H,26,29)
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n/an/a 20n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532094
PNG
(US11208404, Compound 305)
Show SMILES FC(F)Oc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H11ClF3N3O4/c21-11-4-6-15(30-20(23)24)12(9-11)17(28)25-14-8-10(3-5-13(14)22)18-26-27-19(31-18)16-2-1-7-29-16/h1-9,20H,(H,25,28)
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n/an/a 21n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532083
PNG
(US11208404, Compound 316)
Show SMILES Fc1ccc(cc1NC(=O)c1cc(Cl)ccc1OCC(F)(F)F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H12ClF4N3O4/c22-12-4-6-16(32-10-21(24,25)26)13(9-12)18(30)27-15-8-11(3-5-14(15)23)19-28-29-20(33-19)17-2-1-7-31-17/h1-9H,10H2,(H,27,30)
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n/an/a 21n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532091
PNG
(US11208404, Compound 281)
Show SMILES CCCc1ccc(OC)c(c1)C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H20FN3O4/c1-3-5-14-7-10-19(29-2)16(12-14)21(28)25-18-13-15(8-9-17(18)24)22-26-27-23(31-22)20-6-4-11-30-20/h4,6-13H,3,5H2,1-2H3,(H,25,28)
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n/an/a 24n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532071
PNG
(US11208404, Compound 183)
Show SMILES COc1ccc(Br)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H13BrFN3O4/c1-27-16-7-5-12(21)10-13(16)18(26)23-15-9-11(4-6-14(15)22)19-24-25-20(29-19)17-3-2-8-28-17/h2-10H,1H3,(H,23,26)
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n/an/a 24n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532088
PNG
(US11208404, Compound 318)
Show SMILES C[F]COc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H15ClF2N3O4/c1-24-11-30-17-7-5-13(22)10-14(17)19(28)25-16-9-12(4-6-15(16)23)20-26-27-21(31-20)18-3-2-8-29-18/h2-10H,11H2,1H3,(H,25,28)
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n/an/a 24n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532080
PNG
(US11208404, Compound 209)
Show SMILES CCCOc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C22H17ClFN3O4/c1-2-9-29-18-8-6-14(23)12-15(18)20(28)25-17-11-13(5-7-16(17)24)21-26-27-22(31-21)19-4-3-10-30-19/h3-8,10-12H,2,9H2,1H3,(H,25,28)
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n/an/a 25n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532073
PNG
(US11208404, Compound 215)
Show SMILES CCOc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16FN3O4/c1-2-27-17-7-4-3-6-14(17)19(26)23-16-12-13(9-10-15(16)22)20-24-25-21(29-20)18-8-5-11-28-18/h3-12H,2H2,1H3,(H,23,26)
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n/an/a 26n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532085
PNG
(US11208404, Compound 323)
Show SMILES Cc1ccc(OCC(F)F)c(c1)C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C22H16F3N3O4/c1-12-4-7-17(31-11-19(24)25)14(9-12)20(29)26-16-10-13(5-6-15(16)23)21-27-28-22(32-21)18-3-2-8-30-18/h2-10,19H,11H2,1H3,(H,26,29)
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n/an/a 26n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532076
PNG
(US11208404, Compound 315)
Show SMILES C[F]COc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16F2N3O4/c1-23-12-29-17-6-3-2-5-14(17)19(27)24-16-11-13(8-9-15(16)22)20-25-26-21(30-20)18-7-4-10-28-18/h2-11H,12H2,1H3,(H,24,27)
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n/an/a 28n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532069
PNG
(US11208404, Compound 128)
Show SMILES COc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H14FN3O4/c1-26-16-6-3-2-5-13(16)18(25)22-15-11-12(8-9-14(15)21)19-23-24-20(28-19)17-7-4-10-27-17/h2-11H,1H3,(H,22,25)
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n/an/a 29n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532075
PNG
(US11208404, Compound 314)
Show SMILES FC(F)COc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H14F3N3O4/c22-14-8-7-12(20-26-27-21(31-20)17-6-3-9-29-17)10-15(14)25-19(28)13-4-1-2-5-16(13)30-11-18(23)24/h1-10,18H,11H2,(H,25,28)
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n/an/a 29n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532072
PNG
(US11208404, Compound 300)
Show SMILES COc1ccc(C)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16FN3O4/c1-12-5-8-17(27-2)14(10-12)19(26)23-16-11-13(6-7-15(16)22)20-24-25-21(29-20)18-4-3-9-28-18/h3-11H,1-2H3,(H,23,26)
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n/an/a 30n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532077
PNG
(US11208404, Compound 221)
Show SMILES CCOc1ccc(C)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C22H18FN3O4/c1-3-28-18-9-6-13(2)11-15(18)20(27)24-17-12-14(7-8-16(17)23)21-25-26-22(30-21)19-5-4-10-29-19/h4-12H,3H2,1-2H3,(H,24,27)
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n/an/a 31n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532059
PNG
(US11208404, Compound 118)
Show SMILES CCOc1ccc(Br)cc1C(=O)Nc1cccc(c1)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16BrN3O4/c1-2-27-17-9-8-14(22)12-16(17)19(26)23-15-6-3-5-13(11-15)20-24-25-21(29-20)18-7-4-10-28-18/h3-12H,2H2,1H3,(H,23,26)
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n/an/a 31n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532096
PNG
(US11208404, Compound 312)
Show SMILES C[F]COc1ccc(F)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H15F3N3O4/c1-24-11-30-17-7-5-13(22)10-14(17)19(28)25-16-9-12(4-6-15(16)23)20-26-27-21(31-20)18-3-2-8-29-18/h2-10H,11H2,1H3,(H,25,28)
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n/an/a 33n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532060
PNG
(US11208404, Compound 200)
Show SMILES CCOc1ccc(I)cc1C(=O)Nc1cccc(c1)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16IN3O4/c1-2-27-17-9-8-14(22)12-16(17)19(26)23-15-6-3-5-13(11-15)20-24-25-21(29-20)18-7-4-10-28-18/h3-12H,2H2,1H3,(H,23,26)
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n/an/a 33n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532062
PNG
(US11208404, Compound 219)
Show SMILES CCOc1ccc(CC)cc1C(=O)Nc1cccc(c1)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H21N3O4/c1-3-15-10-11-19(28-4-2)18(13-15)21(27)24-17-8-5-7-16(14-17)22-25-26-23(30-22)20-9-6-12-29-20/h5-14H,3-4H2,1-2H3,(H,24,27)
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n/an/a 34n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532087
PNG
(US11208404, Compound 320)
Show SMILES FC(F)COc1ccc(F)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H13F4N3O4/c22-12-4-6-16(31-10-18(24)25)13(9-12)19(29)26-15-8-11(3-5-14(15)23)20-27-28-21(32-20)17-2-1-7-30-17/h1-9,18H,10H2,(H,26,29)
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n/an/a 34n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532059
PNG
(US11208404, Compound 118)
Show SMILES CCOc1ccc(Br)cc1C(=O)Nc1cccc(c1)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16BrN3O4/c1-2-27-17-9-8-14(22)12-16(17)19(26)23-15-6-3-5-13(11-15)20-24-25-21(29-20)18-7-4-10-28-18/h3-12H,2H2,1H3,(H,23,26)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532060
PNG
(US11208404, Compound 200)
Show SMILES CCOc1ccc(I)cc1C(=O)Nc1cccc(c1)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16IN3O4/c1-2-27-17-9-8-14(22)12-16(17)19(26)23-15-6-3-5-13(11-15)20-24-25-21(29-20)18-7-4-10-28-18/h3-12H,2H2,1H3,(H,23,26)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532062
PNG
(US11208404, Compound 219)
Show SMILES CCOc1ccc(CC)cc1C(=O)Nc1cccc(c1)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H21N3O4/c1-3-15-10-11-19(28-4-2)18(13-15)21(27)24-17-8-5-7-16(14-17)22-25-26-23(30-22)20-9-6-12-29-20/h5-14H,3-4H2,1-2H3,(H,24,27)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532067
PNG
(US11208404, Compound 184)
Show SMILES COc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H13ClFN3O4/c1-27-16-7-5-12(21)10-13(16)18(26)23-15-9-11(4-6-14(15)22)19-24-25-20(29-19)17-3-2-8-28-17/h2-10H,1H3,(H,23,26)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532068
PNG
(US11208404, Compound 216)
Show SMILES CCOc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H15ClFN3O4/c1-2-28-17-8-6-13(22)11-14(17)19(27)24-16-10-12(5-7-15(16)23)20-25-26-21(30-20)18-4-3-9-29-18/h3-11H,2H2,1H3,(H,24,27)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532069
PNG
(US11208404, Compound 128)
Show SMILES COc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H14FN3O4/c1-26-16-6-3-2-5-13(16)18(25)22-15-11-12(8-9-14(15)21)19-23-24-20(28-19)17-7-4-10-27-17/h2-11H,1H3,(H,22,25)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532071
PNG
(US11208404, Compound 183)
Show SMILES COc1ccc(Br)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H13BrFN3O4/c1-27-16-7-5-12(21)10-13(16)18(26)23-15-9-11(4-6-14(15)22)19-24-25-20(29-19)17-3-2-8-28-17/h2-10H,1H3,(H,23,26)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532072
PNG
(US11208404, Compound 300)
Show SMILES COc1ccc(C)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16FN3O4/c1-12-5-8-17(27-2)14(10-12)19(26)23-16-11-13(6-7-15(16)22)20-24-25-21(29-20)18-4-3-9-28-18/h3-11H,1-2H3,(H,23,26)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532073
PNG
(US11208404, Compound 215)
Show SMILES CCOc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16FN3O4/c1-2-27-17-7-4-3-6-14(17)19(26)23-16-12-13(9-10-15(16)22)20-24-25-21(29-20)18-8-5-11-28-18/h3-12H,2H2,1H3,(H,23,26)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532075
PNG
(US11208404, Compound 314)
Show SMILES FC(F)COc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H14F3N3O4/c22-14-8-7-12(20-26-27-21(31-20)17-6-3-9-29-17)10-15(14)25-19(28)13-4-1-2-5-16(13)30-11-18(23)24/h1-10,18H,11H2,(H,25,28)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532076
PNG
(US11208404, Compound 315)
Show SMILES C[F]COc1ccccc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H16F2N3O4/c1-23-12-29-17-6-3-2-5-14(17)19(27)24-16-11-13(8-9-15(16)22)20-25-26-21(30-20)18-7-4-10-28-18/h2-11H,12H2,1H3,(H,24,27)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532077
PNG
(US11208404, Compound 221)
Show SMILES CCOc1ccc(C)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C22H18FN3O4/c1-3-28-18-9-6-13(2)11-15(18)20(27)24-17-12-14(7-8-16(17)23)21-25-26-22(30-21)19-5-4-10-29-19/h4-12H,3H2,1-2H3,(H,24,27)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532080
PNG
(US11208404, Compound 209)
Show SMILES CCCOc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C22H17ClFN3O4/c1-2-9-29-18-8-6-14(23)12-15(18)20(28)25-17-11-13(5-7-16(17)24)21-26-27-22(31-21)19-4-3-10-30-19/h3-8,10-12H,2,9H2,1H3,(H,25,28)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532083
PNG
(US11208404, Compound 316)
Show SMILES Fc1ccc(cc1NC(=O)c1cc(Cl)ccc1OCC(F)(F)F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H12ClF4N3O4/c22-12-4-6-16(32-10-21(24,25)26)13(9-12)18(30)27-15-8-11(3-5-14(15)23)19-28-29-20(33-19)17-2-1-7-31-17/h1-9H,10H2,(H,27,30)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532085
PNG
(US11208404, Compound 323)
Show SMILES Cc1ccc(OCC(F)F)c(c1)C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C22H16F3N3O4/c1-12-4-7-17(31-11-19(24)25)14(9-12)20(29)26-16-10-13(5-6-15(16)23)21-27-28-22(32-21)18-3-2-8-30-18/h2-10,19H,11H2,1H3,(H,26,29)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532086
PNG
(US11208404, Compound 317)
Show SMILES FC(F)COc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H13ClF3N3O4/c22-12-4-6-16(31-10-18(24)25)13(9-12)19(29)26-15-8-11(3-5-14(15)23)20-27-28-21(32-20)17-2-1-7-30-17/h1-9,18H,10H2,(H,26,29)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532087
PNG
(US11208404, Compound 320)
Show SMILES FC(F)COc1ccc(F)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H13F4N3O4/c22-12-4-6-16(31-10-18(24)25)13(9-12)19(29)26-15-8-11(3-5-14(15)23)20-27-28-21(32-20)17-2-1-7-30-17/h1-9,18H,10H2,(H,26,29)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532088
PNG
(US11208404, Compound 318)
Show SMILES C[F]COc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C21H15ClF2N3O4/c1-24-11-30-17-7-5-13(22)10-14(17)19(28)25-16-9-12(4-6-15(16)23)20-26-27-21(31-20)18-3-2-8-29-18/h2-10H,11H2,1H3,(H,25,28)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532091
PNG
(US11208404, Compound 281)
Show SMILES CCCc1ccc(OC)c(c1)C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C23H20FN3O4/c1-3-5-14-7-10-19(29-2)16(12-14)21(28)25-18-13-15(8-9-17(18)24)22-26-27-23(31-22)20-6-4-11-30-20/h4,6-13H,3,5H2,1-2H3,(H,25,28)
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n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532093
PNG
(US11208404, Compound 304)
Show SMILES Fc1ccc(cc1NC(=O)c1cc(Cl)ccc1OC(F)(F)F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H10ClF4N3O4/c21-11-4-6-15(32-20(23,24)25)12(9-11)17(29)26-14-8-10(3-5-13(14)22)18-27-28-19(31-18)16-2-1-7-30-16/h1-9H,(H,26,29)
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US Patent
n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
Lysocardiolipin acyltransferase 1


(Human)
BDBM532094
PNG
(US11208404, Compound 305)
Show SMILES FC(F)Oc1ccc(Cl)cc1C(=O)Nc1cc(ccc1F)-c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C20H11ClF3N3O4/c21-11-4-6-15(30-20(23)24)12(9-11)17(28)25-14-8-10(3-5-13(14)22)18-26-27-19(31-18)16-2-1-7-29-16/h1-9,20H,(H,25,28)
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a<35n/an/an/an/an/an/a



PERENNA PHARMACEUTICALS, INC.

US Patent


Assay Description
ALCAT1 enzymatic activity was determined by measuring the conversion of monolysocardiolipin (MLCL) to cardiolipin or lysophosphatidylglycerol (LPG) t...


US Patent US11208404 (2021)

More data for this
Ligand-Target Pair
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