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Found 30 of ec50 for UniProtKB: P27815
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393511(CHEMBL2158056)
Affinity DataEC50:  15nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393510(CHEMBL1232082)
Affinity DataEC50:  17nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50085135(4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic...)
Affinity DataEC50:  20nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223120(CHEMBL31063)
Affinity DataEC50:  200nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393509(PYRIDOPYRIDAZINONE)
Affinity DataEC50:  220nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataEC50:  250nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393512(CHEMBL2158057)
Affinity DataEC50:  270nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50042058((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Affinity DataEC50:  480nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataEC50:  500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393515(CHEMBL2158061)
Affinity DataEC50:  500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223118(CHEMBL31530)
Affinity DataEC50:  600nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223052(CHEMBL30733)
Affinity DataEC50:  700nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50240404((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Affinity DataEC50:  900nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50040348(8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...)
Affinity DataEC50:  910nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223121(CHEMBL281244)
Affinity DataEC50:  1.05E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223097(CHEMBL28562)
Affinity DataEC50:  1.70E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223189(CHEMBL288545)
Affinity DataEC50:  1.80E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223129(CHEMBL30379)
Affinity DataEC50:  1.80E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223128(CHEMBL31795)
Affinity DataEC50:  2.00E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393517(CHEMBL2158063)
Affinity DataEC50:  2.10E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223055(CHEMBL31439)
Affinity DataEC50:  2.10E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50010981((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)
Affinity DataEC50:  3.30E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223187(CHEMBL30966)
Affinity DataEC50:  3.40E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataEC50:  3.40E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223132(CHEMBL30619)
Affinity DataEC50:  3.50E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393523(CHEMBL2158068)
Affinity DataEC50:  4.60E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393521(CHEMBL2158067)
Affinity DataEC50:  5.60E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50471841(CHEMBL334988)
Affinity DataEC50:  7.50E+3nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50223123(CHEMBL31877)
Affinity DataEC50:  1.80E+4nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50471846(CHEMBL434822)
Affinity DataEC50:  2.10E+4nMAssay Description:Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophilsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed