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Compile Data Set for Download or QSAR

Found 1635 hits of ic50 for UniProtKB: Q6V1X1   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389480
PNG
(CHEMBL2063040)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O
Show InChI InChI=1S/C10H22BN5O4/c12-7(2-1-3-15-10(13)14)9(18)16-5-6(17)4-8(16)11(19)20/h6-8,17,19-20H,1-5,12H2,(H4,13,14,15)/t6-,7-,8-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50050513
PNG
((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389473
PNG
(CHEMBL2063033)
Show SMILES OB(O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1
Show InChI InChI=1S/C9H17BN2O4/c13-6-4-8(10(15)16)12(5-6)9(14)7-2-1-3-11-7/h6-8,11,13,15-16H,1-5H2/t6-,7-,8-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350168
PNG
(CHEMBL1814740)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C29H30ClFN4O2/c30-24-9-6-21(7-10-24)28(20-4-2-1-3-5-20)34-14-12-33(13-15-34)27(36)17-26(32)29(37)35-18-22-8-11-25(31)16-23(22)19-35/h1-11,16,26,28H,12-15,17-19,32H2/t26-,28?/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389465
PNG
(CHEMBL2063024)
Show SMILES C[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O
Show InChI InChI=1S/C7H15BN2O4/c1-4(9)7(12)10-3-5(11)2-6(10)8(13)14/h4-6,11,13-14H,2-3,9H2,1H3/t4-,5-,6-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350166
PNG
(CHEMBL1814739)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C29H29F3N4O2/c30-23-6-1-19(2-7-23)28(20-3-8-24(31)9-4-20)35-13-11-34(12-14-35)27(37)16-26(33)29(38)36-17-21-5-10-25(32)15-22(21)18-36/h1-10,15,26,28H,11-14,16-18,33H2/t26-/m0/s1
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n/an/a 9.40n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350167
PNG
(CHEMBL1814741)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C29H31ClN4O2/c30-25-12-10-22(11-13-25)28(21-6-2-1-3-7-21)33-16-14-32(15-17-33)27(35)18-26(31)29(36)34-19-23-8-4-5-9-24(23)20-34/h1-13,26,28H,14-20,31H2/t26-,28?/m0/s1
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n/an/a 9.90n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243649
PNG
((2S,4S)-1-((2S,3R)-2-amino-3-methylpentanoyl)-4-az...)
Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1C[C@H](C[C@H]1C#N)N=[N+]=[N-]
Show InChI InChI=1S/C11H18N6O/c1-3-7(2)10(13)11(18)17-6-8(15-16-14)4-9(17)5-12/h7-10H,3-4,6,13H2,1-2H3/t7-,8+,9+,10+/m1/s1
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n/an/a 11n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50206038
PNG
(((2S,4S)-4-(4-(4-nitrophenyl)piperazin-1-yl)pyrrol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H25N5O3S/c24-18(22-9-10-27-13-22)17-11-16(12-19-17)21-7-5-20(6-8-21)14-1-3-15(4-2-14)23(25)26/h1-4,16-17,19H,5-13H2/t16-,17-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay


Bioorg Med Chem 20: 5705-19 (2012)


Article DOI: 10.1016/j.bmc.2012.08.012
BindingDB Entry DOI: 10.7270/Q2JQ123C
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350169
PNG
(CHEMBL1814633)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2/t26-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50359373
PNG
(CHEMBL1929394)
Show SMILES Cc1nc2cc(nn2c(C)c1C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N)-c1ccccc1
Show InChI InChI=1S/C26H31N7O2/c1-17-24(18(2)33-22(30-17)13-21(31-33)19-9-6-5-7-10-19)25(35)28-16-26(3,4)29-15-23(34)32-12-8-11-20(32)14-27/h5-7,9-10,13,20,29H,8,11-12,15-16H2,1-4H3,(H,28,35)/t20-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP-8 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...


Bioorg Med Chem 19: 7221-7 (2011)


Article DOI: 10.1016/j.bmc.2011.09.043
BindingDB Entry DOI: 10.7270/Q2862GVX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50206038
PNG
(((2S,4S)-4-(4-(4-nitrophenyl)piperazin-1-yl)pyrrol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H25N5O3S/c24-18(22-9-10-27-13-22)17-11-16(12-19-17)21-7-5-20(6-8-21)14-1-3-15(4-2-14)23(25)26/h1-4,16-17,19H,5-13H2/t16-,17-/m0/s1
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n/an/a 12.2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8 using Gly-Pro-MCA as substrate after 30 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50050525
PNG
((R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic...)
Show SMILES C[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C7H15BN2O3/c1-5(9)7(11)10-4-2-3-6(10)8(12)13/h5-6,12-13H,2-4,9H2,1H3/t5-,6-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243690
PNG
((2S,4S)-1-((S)-2-amino-6-(naphthalen-2-ylamino)hex...)
Show SMILES N[C@@H](CCCCNc1ccc2ccccc2c1)C(=O)N1C[C@H](C[C@H]1C#N)N=[N+]=[N-]
Show InChI InChI=1S/C21H25N7O/c22-13-19-12-18(26-27-24)14-28(19)21(29)20(23)7-3-4-10-25-17-9-8-15-5-1-2-6-16(15)11-17/h1-2,5-6,8-9,11,18-20,25H,3-4,7,10,12,14,23H2/t18-,19-,20-/m0/s1
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n/an/a 13.8n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12195
PNG
(2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-...)
Show SMILES NC(CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2
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n/an/a 14n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 15: 687-91 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.023
BindingDB Entry DOI: 10.7270/Q2XG9PDW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350169
PNG
(CHEMBL1814633)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2/t26-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of DPP8


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12183
PNG
((2S)-1-[(2S)-2-amino-4-{4-[bis(4-fluorophenyl)meth...)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C26H29F2N5O2/c27-20-7-3-18(4-8-20)25(19-5-9-21(28)10-6-19)32-14-12-31(13-15-32)24(34)16-23(30)26(35)33-11-1-2-22(33)17-29/h3-10,22-23,25H,1-2,11-16,30H2/t22-,23-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP8 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50171552
PNG
((S)-2-(S)-Amino-1-(2-boron-dihydroxide-pyrrolidine...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8+/m1/s1
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n/an/a 15n/an/an/an/an/an/a



ActivX Biosciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against human dipeptidylpeptidase 8 using FP-TAMRA incubated for 30 min


Bioorg Med Chem Lett 15: 4256-60 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.076
BindingDB Entry DOI: 10.7270/Q2RR1XSW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12183
PNG
((2S)-1-[(2S)-2-amino-4-{4-[bis(4-fluorophenyl)meth...)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C26H29F2N5O2/c27-20-7-3-18(4-8-20)25(19-5-9-21(28)10-6-19)32-14-12-31(13-15-32)24(34)16-23(30)26(35)33-11-1-2-22(33)17-29/h3-10,22-23,25H,1-2,11-16,30H2/t22-,23-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibitory concentration against Dipeptidyl-peptidase 8


Bioorg Med Chem Lett 15: 3271-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.051
BindingDB Entry DOI: 10.7270/Q2RF5TJX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12183
PNG
((2S)-1-[(2S)-2-amino-4-{4-[bis(4-fluorophenyl)meth...)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C26H29F2N5O2/c27-20-7-3-18(4-8-20)25(19-5-9-21(28)10-6-19)32-14-12-31(13-15-32)24(34)16-23(30)26(35)33-11-1-2-22(33)17-29/h3-10,22-23,25H,1-2,11-16,30H2/t22-,23-/m0/s1
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n/an/a 16n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 15: 687-91 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.023
BindingDB Entry DOI: 10.7270/Q2XG9PDW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389471
PNG
(CHEMBL2063031)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O
Show InChI InChI=1S/C10H21BN2O4/c1-10(2,3)8(12)9(15)13-5-6(14)4-7(13)11(16)17/h6-8,14,16-17H,4-5,12H2,1-3H3/t6-,7-,8+/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50050513
PNG
((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Show SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8


Bioorg Med Chem Lett 17: 507-10 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.012
BindingDB Entry DOI: 10.7270/Q2T43SQH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50168268
PNG
((S)-1-[(S)-2-Amino-4-(6,7-dimethoxy-3,4-dihydro-1H...)
Show SMILES COc1cc2CCN(Cc2cc1OC)C(=O)C[C@H](N)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H26N4O4/c1-27-17-8-13-5-7-23(12-14(13)9-18(17)28-2)19(25)10-16(22)20(26)24-6-3-4-15(24)11-21/h8-9,15-16H,3-7,10,12,22H2,1-2H3/t15-,16-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibitory concentration against Dipeptidyl-peptidase 8


Bioorg Med Chem Lett 15: 3271-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.051
BindingDB Entry DOI: 10.7270/Q2RF5TJX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12182
PNG
((2S)-1-[(2S)-2-amino-4-oxo-4-(1,2,3,4-tetrahydrois...)
Show SMILES N[C@@H](CC(=O)N1CCc2ccccc2C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C18H22N4O2/c19-11-15-6-3-8-22(15)18(24)16(20)10-17(23)21-9-7-13-4-1-2-5-14(13)12-21/h1-2,4-5,15-16H,3,6-10,12,20H2/t15-,16-/m0/s1
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n/an/a 19n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 15: 687-91 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.023
BindingDB Entry DOI: 10.7270/Q2XG9PDW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389477
PNG
(CHEMBL2063037)
Show SMILES OB(O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1C[C@H](O)CN1
Show InChI InChI=1S/C9H17BN2O5/c13-5-1-7(11-3-5)9(15)12-4-6(14)2-8(12)10(16)17/h5-8,11,13-14,16-17H,1-4H2/t5-,6-,7-,8-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243687
PNG
(CHEMBL471747 | benzyl (S)-5-amino-6-((2S,4S)-4-azi...)
Show SMILES N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C#N)N=[N+]=[N-]
Show InChI InChI=1S/C19H25N7O3/c20-11-16-10-15(24-25-22)12-26(16)18(27)17(21)8-4-5-9-23-19(28)29-13-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-10,12-13,21H2,(H,23,28)/t15-,16-,17-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50320300
PNG
((S)-1-(2-((2alpha,3aR,5S,6aS)-5-methoxyoctahydrope...)
Show SMILES CO[C@@H]1C[C@@H]2C[C@H](C[C@@H]2C1)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H25N3O2/c1-21-15-7-11-5-13(6-12(11)8-15)18-10-16(20)19-4-2-3-14(19)9-17/h11-15,18H,2-8,10H2,1H3/t11-,12+,13+,14-,15+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP8 by chemical luminescent assay


Bioorg Med Chem Lett 20: 3521-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.138
BindingDB Entry DOI: 10.7270/Q2JH3MBT
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389467
PNG
(CHEMBL2063026)
Show SMILES C[C@H](N)C(=O)N1C[C@H](F)C[C@H]1B(O)O
Show InChI InChI=1S/C7H14BFN2O3/c1-4(10)7(12)11-3-5(9)2-6(11)8(13)14/h4-6,13-14H,2-3,10H2,1H3/t4-,5+,6-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12192
PNG
((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Show SMILES N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C16H22N2O/c17-15(12-6-2-1-3-7-12)16(19)18-10-13-8-4-5-9-14(13)11-18/h4-5,8-9,12,15H,1-3,6-7,10-11,17H2/t15-/m0/s1
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n/an/a 24n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 15: 687-91 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.023
BindingDB Entry DOI: 10.7270/Q2XG9PDW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11694
PNG
((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)
Show SMILES N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H21N3O/c14-9-11-7-4-8-16(11)13(17)12(15)10-5-2-1-3-6-10/h10-12H,1-8,15H2/t11-,12-/m0/s1
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n/an/a 27n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 15: 687-91 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.023
BindingDB Entry DOI: 10.7270/Q2XG9PDW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11694
PNG
((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)
Show SMILES N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H21N3O/c14-9-11-7-4-8-16(11)13(17)12(15)10-5-2-1-3-6-10/h10-12H,1-8,15H2/t11-,12-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibitory concentration against Dipeptidyl-peptidase 8


Bioorg Med Chem Lett 15: 3271-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.051
BindingDB Entry DOI: 10.7270/Q2RF5TJX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389475
PNG
(CHEMBL2063035)
Show SMILES OB(O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1C[C@@H](O)CN1
Show InChI InChI=1S/C9H17BN2O5/c13-5-1-7(11-3-5)9(15)12-4-6(14)2-8(12)10(16)17/h5-8,11,13-14,16-17H,1-4H2/t5-,6+,7+,8+/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM11694
PNG
((2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidin...)
Show SMILES N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H21N3O/c14-9-11-7-4-8-16(11)13(17)12(15)10-5-2-1-3-6-10/h10-12H,1-8,15H2/t11-,12-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


J Med Chem 49: 373-80 (2006)


Article DOI: 10.1021/jm0507781
BindingDB Entry DOI: 10.7270/Q28W3BJH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50168275
PNG
(1-{4-[(S)-3-Amino-4-((S)-2-cyano-pyrrolidin-1-yl)-...)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)[n+]1cccc(c1)C#N)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C19H24N7O2/c20-12-15-3-1-5-25(14-15)24-9-7-23(8-10-24)18(27)11-17(22)19(28)26-6-2-4-16(26)13-21/h1,3,5,14,16-17H,2,4,6-11,22H2/q+1/t16-,17-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibitory concentration against Dipeptidyl-peptidase 8


Bioorg Med Chem Lett 15: 3271-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.051
BindingDB Entry DOI: 10.7270/Q2RF5TJX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350170
PNG
(CHEMBL1814753)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(=O)c1cccc(c1)-c1ccccc1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C29H30N4O3/c30-26(29(36)33-19-24-9-4-5-10-25(24)20-33)18-27(34)31-13-15-32(16-14-31)28(35)23-12-6-11-22(17-23)21-7-2-1-3-8-21/h1-12,17,26H,13-16,18-20,30H2/t26-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50171548
PNG
((S)-2-(S)-Amino-1-(2-boron-dihydroxide-pyrrolidin-...)
Show SMILES CCCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C10H21BN2O3/c1-2-3-5-8(12)10(14)13-7-4-6-9(13)11(15)16/h8-9,15-16H,2-7,12H2,1H3/t8-,9+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



ActivX Biosciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against human dipeptidylpeptidase 8 using FP-TAMRA incubated for 30 min


Bioorg Med Chem Lett 15: 4256-60 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.076
BindingDB Entry DOI: 10.7270/Q2RR1XSW
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350172
PNG
(CHEMBL1814748)
Show SMILES C[C@H]1CN(CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)C[C@H](N)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C30H32F2N4O2/c1-20-17-34(28(37)16-27(33)30(38)35-18-23-4-2-3-5-24(23)19-35)14-15-36(20)29(21-6-10-25(31)11-7-21)22-8-12-26(32)13-9-22/h2-13,20,27,29H,14-19,33H2,1H3/t20-,27-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50206058
PNG
(6-(4-((3S,5S)-5-(thiazolidine-3-carbonyl)pyrrolidi...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ccc(cn1)C#N)N1CCSC1
Show InChI InChI=1S/C18H24N6OS/c19-10-14-1-2-17(21-11-14)23-5-3-22(4-6-23)15-9-16(20-12-15)18(25)24-7-8-26-13-24/h1-2,11,15-16,20H,3-9,12-13H2/t15-,16-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay


Bioorg Med Chem 20: 5705-19 (2012)


Article DOI: 10.1016/j.bmc.2012.08.012
BindingDB Entry DOI: 10.7270/Q2JQ123C
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389472
PNG
(CHEMBL2063032)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1C[C@H](O)C[C@H]1B(O)O
Show InChI InChI=1S/C10H21BN2O4/c1-10(2,3)8(12)9(15)13-5-6(14)4-7(13)11(16)17/h6-8,14,16-17H,4-5,12H2,1-3H3/t6-,7+,8-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243187
PNG
((S)-2-amino-1-(isoindolin-2-yl)-6-(naphthalen-2-yl...)
Show SMILES N[C@@H](CCCCNc1ccc2ccccc2c1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C24H27N3O/c25-23(24(28)27-16-20-9-3-4-10-21(20)17-27)11-5-6-14-26-22-13-12-18-7-1-2-8-19(18)15-22/h1-4,7-10,12-13,15,23,26H,5-6,11,14,16-17,25H2/t23-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50359371
PNG
(CHEMBL1929392)
Show SMILES Cc1c(cnc2cc(nn12)-c1ccccc1)C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C25H29N7O2/c1-17-20(14-27-22-12-21(30-32(17)22)18-8-5-4-6-9-18)24(34)28-16-25(2,3)29-15-23(33)31-11-7-10-19(31)13-26/h4-6,8-9,12,14,19,29H,7,10-11,15-16H2,1-3H3,(H,28,34)/t19-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP-8 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...


Bioorg Med Chem 19: 7221-7 (2011)


Article DOI: 10.1016/j.bmc.2011.09.043
BindingDB Entry DOI: 10.7270/Q2862GVX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50359374
PNG
(CHEMBL1929395)
Show SMILES Cc1cc2nc(C)c(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(C)n2n1
Show InChI InChI=1S/C21H29N7O2/c1-13-9-17-25-14(2)19(15(3)28(17)26-13)20(30)23-12-21(4,5)24-11-18(29)27-8-6-7-16(27)10-22/h9,16,24H,6-8,11-12H2,1-5H3,(H,23,30)/t16-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP-8 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...


Bioorg Med Chem 19: 7221-7 (2011)


Article DOI: 10.1016/j.bmc.2011.09.043
BindingDB Entry DOI: 10.7270/Q2862GVX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350175
PNG
(CHEMBL1814749)
Show SMILES C[C@@H]1CN(CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)C[C@H](N)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C30H32F2N4O2/c1-20-17-34(28(37)16-27(33)30(38)35-18-23-4-2-3-5-24(23)19-35)14-15-36(20)29(21-6-10-25(31)11-7-21)22-8-12-26(32)13-9-22/h2-13,20,27,29H,14-19,33H2,1H3/t20-,27+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243358
PNG
((R)-3-((S)-2-amino-3-methylbutanoyl)thiazolidin-4-...)
Show SMILES CC(C)[C@H](N)C(=O)N1CSC[C@H]1B(O)O
Show InChI InChI=1S/C8H17BN2O3S/c1-5(2)7(10)8(12)11-4-15-3-6(11)9(13)14/h5-7,13-14H,3-4,10H2,1-2H3/t6-,7-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50389469
PNG
(CHEMBL2063029)
Show SMILES N[C@@H](CCC(O)=O)C(=O)N1C[C@@H](O)C[C@H]1B(O)O
Show InChI InChI=1S/C9H17BN2O6/c11-6(1-2-8(14)15)9(16)12-4-5(13)3-7(12)10(17)18/h5-7,13,17-18H,1-4,11H2,(H,14,15)/t5-,6-,7-/m0/s1
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n/an/a 54n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...


Bioorg Med Chem Lett 22: 5536-40 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.033
BindingDB Entry DOI: 10.7270/Q2M909QF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50359369
PNG
(CHEMBL1929390)
Show SMILES Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(=O)n2[nH]1
Show InChI InChI=1S/C19H25N7O3/c1-12-7-15-21-9-14(18(29)26(15)24-12)17(28)22-11-19(2,3)23-10-16(27)25-6-4-5-13(25)8-20/h7,9,13,23-24H,4-6,10-11H2,1-3H3,(H,22,28)/t13-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP-8 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...


Bioorg Med Chem 19: 7221-7 (2011)


Article DOI: 10.1016/j.bmc.2011.09.043
BindingDB Entry DOI: 10.7270/Q2862GVX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50350171
PNG
(CHEMBL1814742)
Show SMILES N[C@@H](CC(=O)N1CCN(Cc2ccc3ccccc3c2)CC1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C27H30N4O2/c28-25(27(33)31-18-23-7-3-4-8-24(23)19-31)16-26(32)30-13-11-29(12-14-30)17-20-9-10-21-5-1-2-6-22(21)15-20/h1-10,15,25H,11-14,16-19,28H2/t25-/m0/s1
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n/an/a 63n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...


J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50359366
PNG
(CHEMBL1929387 | CHEMBL1929396)
Show SMILES Cc1cc2ncc(cn2n1)C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C19H25N7O2/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)/t15-/m0/s1
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n/an/a 68n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP-8 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...


Bioorg Med Chem 19: 7221-7 (2011)


Article DOI: 10.1016/j.bmc.2011.09.043
BindingDB Entry DOI: 10.7270/Q2862GVX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50168272
PNG
((S)-1-[(S)-2-Amino-4-(4-benzoyl-piperazin-1-yl)-4-...)
Show SMILES N[C@@H](CC(=O)N1CCN(CC1)C(=O)c1ccccc1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N5O3/c21-14-16-7-4-8-25(16)20(28)17(22)13-18(26)23-9-11-24(12-10-23)19(27)15-5-2-1-3-6-15/h1-3,5-6,16-17H,4,7-13,22H2/t16-,17-/m0/s1
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n/an/a 71n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibitory concentration against Dipeptidyl-peptidase 8


Bioorg Med Chem Lett 15: 3271-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.051
BindingDB Entry DOI: 10.7270/Q2RF5TJX
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243650
PNG
((2S,4S)-4-azido-1-((S)-2,6-diaminohexanoyl)pyrroli...)
Show SMILES NCCCC[C@H](N)C(=O)N1C[C@H](C[C@H]1C#N)N=[N+]=[N-]
Show InChI InChI=1S/C11H19N7O/c12-4-2-1-3-10(14)11(19)18-7-8(16-17-15)5-9(18)6-13/h8-10H,1-5,7,12,14H2/t8-,9-,10-/m0/s1
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n/an/a 71n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4154-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.080
BindingDB Entry DOI: 10.7270/Q2G160N3
More data for this
Ligand-Target Pair
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