Compile Data Set for Download or QSAR
maximum 50k data
Found 80 of ic50 data for polymerid = 1402
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466803(AMG-900 | AMG900 | Amg 900)
Affinity DataIC50:  1nMAssay Description:Inhibition of Aurora C kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Aurora C using [H-LRRASLG] as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human Aurora C using [H-LRRASLG] as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50:  3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora C (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466802(CHEMBL4277690)
Affinity DataIC50:  3nMAssay Description:Inhibition of Aurora C kinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of aurora C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of Aurora C kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of Aurora C kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  6.5nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50381716(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of AuroraC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  9.10nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged Aurora C (1 to 275 end residues) expressed in baculovirus expression system using G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50307127((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Aurora C in the presence of 5uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)
Affinity DataIC50:  17nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  18.3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant Aurora C expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  24.6nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  25nMAssay Description:In vitro kinase assay using human aurora kinase in a standard radiometric assay.More data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)
Affinity DataIC50:  25.3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM86598(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 3)
Affinity DataIC50:  40.5nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  41nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM12985(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Affinity DataIC50:  61nMAssay Description:Inhibition of aurora C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM12985(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Affinity DataIC50:  61nMAssay Description:Inhibition of Aurora C kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataIC50:  61nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50327912(3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[3,2-c]...)
Affinity DataIC50:  62nMAssay Description:Inhibition of aurora CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataIC50:  65nMAssay Description:Inhibition of aurora C kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50051942(CHEMBL3322563)
Affinity DataIC50:  67nMAssay Description:Inhibition of Aurora C (unknown origin) using H-LRRASLG substrate by radioisotope-based P81 filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Aurora C in the presence of 100uM ATPMore data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50:  91nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50601615(CHEMBL3265229)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50:  120nMAssay Description:Inhibition of GST-tagged recombinant human Aurora C kinase expressed in High5 cells using Auroratide substrate and [gamma33-ATP] by scintillation pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  120nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50051941(CHEMBL3322565)
Affinity DataIC50:  154nMAssay Description:Inhibition of Aurora C (unknown origin) using H-LRRASLG substrate by radioisotope-based P81 filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM4811((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)
Affinity DataIC50:  210nMAssay Description:Inhibition of Aurora C in the presence of 5uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50:  227nMAssay Description:Inhibition of recombinant aurora C kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)
Affinity DataIC50:  290nMAssay Description:Inhibition of wild type human Aurora kinase C kinase by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant aurora C kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50170831(CHEMBL188343 | N*6*-Cyclohexyl-N*2*-(4-morpholin-4...)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant full-length His-tagged human Aurora C expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50191421(3-(3-(methoxyimino)indolin-2-ylidene)indolin-2-one...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant aurora C kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM86617(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  419nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)
Affinity DataIC50:  432nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50591939(CHEMBL5185225)
Affinity DataIC50:  493nMAssay Description:Inhibition of Aurora C (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM311266((S)-1-((4-(difluoromethyl)-2′-methyl-[2,4...)
Affinity DataIC50:  540nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM103302(SCH772984 | US8546404, 6)
Affinity DataIC50:  580nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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