Compile Data Set for Download or QSAR
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Found 473 of ic50 for UniProtKB: P17612
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258601(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-i...)
Affinity DataIC50:  0.0550nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.935nMAssay Description:Inhibition of human PKA using LCGRTGRRNSI as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
LigandPNGBDBM50117489(CHEMBL3613598)
Affinity DataIC50: <1nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117504(CHEMBL3613620)
Affinity DataIC50: <1nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: <1nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117503(CHEMBL3613621)
Affinity DataIC50: <1nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117631(CHEMBL3613610)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.58nMAssay Description:Inhibition of human PKACA using LCGRTGRRNSI as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50:  1.79nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50117632(CHEMBL3613609)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PKACalpha (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
LigandPNGBDBM50117370(CHEMBL3613599)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117299(CHEMBL3613605)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258600(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)
Affinity DataIC50:  3.38nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50117629(CHEMBL3613612)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Affinity DataIC50:  4.06nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50311410(CHEMBL1077376 | N-((5S,8R,11R,14R,17R,20R,23R,33R)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117630(CHEMBL3613611)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50199310(2S,3S,4R,5R)-5-6-amino-9H-purin-9-yl)-N-12R,15R,18...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50199310(2S,3S,4R,5R)-5-6-amino-9H-purin-9-yl)-N-12R,15R,18...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117301(CHEMBL3613603)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50311409(CHEMBL1077375 | N-((6R,9R,12R,15R,18R,21R,31R)-1-a...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50599148(CHEMBL5188777)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of ARC-1063 fluorescent probe binding to recombinant human PKAC-alpha incubated for 1 hr by time-gated luminescence intensity based displa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50117635(CHEMBL3613606)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258596(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Affinity DataIC50:  6.09nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50117300(CHEMBL3613604)
Affinity DataIC50:  7nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258599(US9493490, Example 11 | US9493490, L | US9493490, ...)
Affinity DataIC50:  7.88nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human His-tagged PKA catalytic domain (1 to 351 residues) expressed in Escherichia coli using Ser/Thr 7 as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258597(US9493490, Example 9 | US9493490, F)
Affinity DataIC50:  11.0nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50219803(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)
Affinity DataIC50:  12.9nMAssay Description:Inhibition of cAPK Calpha in presence of 0.1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50311405(CHEMBL1077369 | N-((6R,9R,19R)-1-amino-19-(4-amino...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair
LigandPNGBDBM50117634(CHEMBL3613607)
Affinity DataIC50:  22nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50599147(CHEMBL5201435)
Affinity DataIC50:  24nMAssay Description:Inhibition of ARC-1063 fluorescent probe binding to recombinant human PKAC-alpha incubated for 1 hr by time-gated luminescence intensity based displa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50117633(CHEMBL3613608)
Affinity DataIC50:  24nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117315(CHEMBL3613600)
Affinity DataIC50:  24nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50536679(CHEMBL4568087)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant human His-tagged PRKACA catalytic domain expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50:  29nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50:  29nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM3153(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50285250(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Protein Kinase AMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM3153(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258594(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)
Affinity DataIC50: >50nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM50055668(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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