Compile Data Set for Download or QSAR
maximum 50k data
Found 87 of ec50 for UniProtKB: P34975
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50010704(CHEMBL216640 | Dyn A(1-11)-NH2 | Dynorphin A analo...)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50138770(CHEMBL411282 | cyclo[D-Asp2,Dap5]Dyn A-(1-11)NH2)
Affinity DataEC50:  0.390nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50325534(CHEMBL267495 | nalfurafine)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in ERK1/2 phosphorylation after 5 mins by Wes...More data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataEC50:  0.5nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50138766(CHEMBL439272 | cyclo[D-Ala3]Dyn A-(1-11)NH2)
Affinity DataEC50:  0.540nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496883(CHEMBL3228684)
Affinity DataEC50:  0.600nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50138780(CHEMBL261992 | cyclo[Ala3]Dyn A-(1-11)NH2)
Affinity DataEC50:  0.650nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM82427(CAS_5985-38-6 | LEVORPHANOL-tartarate)
Affinity DataEC50:  0.700nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50297345((5S,8S,13R,Z)-13-((S)-2-amino-3-(4-hydroxyphenyl)p...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001707(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)
Affinity DataEC50:  1nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataEC50:  1nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133053(CHEMBL405057 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  1.24nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataEC50:  1.5nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataEC50:  1.5nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataEC50:  1.5nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataEC50:  1.5nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50231237(CHEBI:6125 | Cetobemidone | Cliradon | Cymidon | K...)
Affinity DataEC50:  2nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  3nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  3nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50452273(Dihydromorphine)
Affinity DataEC50:  3nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  3nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  3nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133054(CHEMBL412228 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  3.56nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496876(CHEMBL3228291)
Affinity DataEC50:  4nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50138777(CHEMBL414904 | cyclo[Trp3]Dyn A-(1-11)NH2)
Affinity DataEC50:  4.19nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133051(CHEMBL413832 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50325534(CHEMBL267495 | nalfurafine)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in beta-arrestin mediated p38 phosphorylation...More data for this Ligand-Target Pair
LigandPNGBDBM50225937(CHEMBL3038189)
Affinity DataEC50:  6nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225933(CHEMBL2310921)
Affinity DataEC50:  6nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM224024(BDBM50241435 | Dynorphin A (1-13) | YGGFLRRXRPKLK)
Affinity DataEC50:  6nMAssay Description:Effective concentration to inhibit E203Q,D204N,D206N KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225935(CHEMBL2310915)
Affinity DataEC50:  7nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225936(CHEMBL3038190)
Affinity DataEC50:  7nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50381677(CHEMBL1256748 | U-69593)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at rat kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM224024(BDBM50241435 | Dynorphin A (1-13) | YGGFLRRXRPKLK)
Affinity DataEC50:  8nMAssay Description:Effective concentration to inhibit D216,ND217N,E218Q KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50297347((2S,5S,8S,13S,Z)-13-((S)-2-(2-(2-((S)-2-amino-3-(4...)
Affinity DataEC50:  8.30nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496873(CHEMBL3228292)
Affinity DataEC50:  9nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496877(CHEMBL33376)
Affinity DataEC50:  9nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496881(CHEMBL3228683)
Affinity DataEC50:  10nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50138765(CHEMBL405307 | cyclo[D-Trp3]Dyn A-(1-11)NH2)
Affinity DataEC50:  12nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496874(CHEMBL3228290)
Affinity DataEC50:  15nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM224024(BDBM50241435 | Dynorphin A (1-13) | YGGFLRRXRPKLK)
Affinity DataEC50:  18nMAssay Description:Effective concentration to inhibit wild type KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496882(CHEMBL3228681)
Affinity DataEC50:  20nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50297347((2S,5S,8S,13S,Z)-13-((S)-2-(2-(2-((S)-2-amino-3-(4...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133049(CHEMBL262310 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  29.4nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133055(CHEMBL441198 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  36.5nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133052(CHEMBL430081 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  46.9nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225940(CHEMBL2310917)
Affinity DataEC50:  50nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50496879(CHEMBL3228679)
Affinity DataEC50:  60nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50133050(CHEMBL385696 | Opioid Peptide [d-Ala(8)]Dynorphin ...)
Affinity DataEC50:  72.4nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225942(CHEMBL2310916)
Affinity DataEC50:  90nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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