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Found 216 of kd for UniProtKB: P04629
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Affinity DataKd:  0.0510nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Affinity DataKd:  0.0510nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Affinity DataKd:  0.0650nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Affinity DataKd:  0.0650nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374719(11-fluoro-14-(propan-2-yl)-6,7,13,14-tetrahydro- 1...)
Affinity DataKd:  0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374719(11-fluoro-14-(propan-2-yl)-6,7,13,14-tetrahydro- 1...)
Affinity DataKd:  0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374718(14-ethyl-11-fluoro-6,7,13,14-tetrahydro-1,15- ethe...)
Affinity DataKd:  0.0860nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374718(14-ethyl-11-fluoro-6,7,13,14-tetrahydro-1,15- ethe...)
Affinity DataKd:  0.0860nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374717(10-fluoro-7-methyl-7,8,15,16-tetrahydro-3,6- ethen...)
Affinity DataKd:  0.0880nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374717(10-fluoro-7-methyl-7,8,15,16-tetrahydro-3,6- ethen...)
Affinity DataKd:  0.0880nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374720(14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Affinity DataKd:  0.140nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374720(14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Affinity DataKd:  0.140nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374721(11-fluoro-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Affinity DataKd:  0.200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374721(11-fluoro-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Affinity DataKd:  0.200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataKd:  0.204nMAssay Description:Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells asse...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374714(12-chloro-11-fluoro-14-methyl-6,7,13,14- tetrahydr...)
Affinity DataKd:  0.230nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374714(12-chloro-11-fluoro-14-methyl-6,7,13,14- tetrahydr...)
Affinity DataKd:  0.230nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50457833(CHEMBL4210892)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) by SPR assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554329(CHEMBL4646064)
Affinity DataKd:  0.810nMAssay Description:Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554333(CHEMBL4790500)
Affinity DataKd:  0.880nMAssay Description:Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50022675(CHEMBL3298268)
Affinity DataKd:  0.940nMAssay Description:Binding affinity to His-tagged TrkA (unknown origin) after 1 hr by SPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50456109(CHEMBL4212119)
Affinity DataKd:  1nMAssay Description:Binding affinity to DNA-tagged human partial length TrkA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554331(CHEMBL4798635)
Affinity DataKd:  1nMAssay Description:Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) assessed as dissociation rate...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50565310(CHEMBL4792981)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to wild-type human partial length TRKA (G475 to G790 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50456107(CHEMBL4204878)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to DNA-tagged human partial length TrkA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  2nMAssay Description:Average Binding Constant for NTRK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554330(CHEMBL4742649)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) by SPR assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to DNA-tagged recombinant human TRKA (475 to 790 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50456110(CHEMBL4216563)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to DNA-tagged human partial length TrkA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) by SPR assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554332(CHEMBL4779847)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to DNA-tagged human partial length TrkA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50022756(CHEMBL3298164)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to His-tagged TrkA (unknown origin) after 1 hr by SPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  4nMAssay Description:Binding constant for TRKA kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50456111(CHEMBL4217093)
Affinity DataKd:  4nMAssay Description:Binding affinity to DNA-tagged human partial length TrkA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  4nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  4nMAssay Description:Binding constant for TRKA kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM226354(US9328096, 47)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to C-terminal-His6/N-terminal BAP-tagged unphosphorylated TrkA (unknown origin) (441 to 796 residues) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  4.5nMAssay Description:Binding constant for TRKA kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50457833(CHEMBL4210892)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) assessed as dissociation rate...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  4.80nMAssay Description:Binding constant for TRKA kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) assessed as dissociation rate...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  6nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  6nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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