Compile Data Set for Download or QSAR
maximum 50k data
Found 100 of ic50 for UniProtKB: P00375
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against dihydrofolate reductase(DHFR) isolated from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50041670(2-{4-[2-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopen...)
Affinity DataIC50:  2.10nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  4nMAssay Description:Inhibition of DHFR in mouse L1210 cells using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  6.60nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50041672(2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyri...)
Affinity DataIC50:  7.10nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50016460((S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-prop...)
Affinity DataIC50:  11nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023721(5-(4-Chloro-benzoylamino)-2-{4-[(2,4-diamino-pteri...)
Affinity DataIC50:  15nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase (DHFR) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase (DHFR) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50020099(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  23nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  25nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  25nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  25nMAssay Description:Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  25nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  25nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from mouse cells (L1210/R71).More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50020100(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  26nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023713(5-Benzoylamino-2-{4-[(2,4-diamino-pteridin-6-ylmet...)
Affinity DataIC50:  27nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023718(5-Acetylamino-2-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Affinity DataIC50:  28nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023722(5-(4-Chloro-benzoylamino)-2-{4-[(2,4-diamino-pteri...)
Affinity DataIC50:  28nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50020098(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  29nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023896(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  31nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase ( DHFR ) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50020097(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  32nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50022332(5-(2-Chloro-acetylamino)-2-{4-[(2,4-diamino-pterid...)
Affinity DataIC50:  32nMAssay Description:Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50022329(6-(2-Chloro-acetylamino)-2-{4-[(2,4-diamino-pterid...)
Affinity DataIC50:  32nMAssay Description:Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023720(5-(3-Carboxy-propionylamino)-2-{4-[(2,4-diamino-pt...)
Affinity DataIC50:  32nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023712(5-Benzoylamino-2-{4-[(2,4-diamino-pteridin-6-ylmet...)
Affinity DataIC50:  34nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50020106(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  34nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  35nMAssay Description:Compound was tested for its ability to inhibit purified dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  35nMAssay Description:Compound was tested for its ability to inhibit purified dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  35nMAssay Description:Compound was tested for its ability to inhibit dihydrofolate reductase purified from murine L1210 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  35nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from mouse cells (L1210/R71).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  35nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023405(3-(Carboxymethyl-{4-[(2,4-diamino-pteridin-6-ylmet...)
Affinity DataIC50:  38nMAssay Description:Inhibitory activity against dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023890(4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diam...)
Affinity DataIC50:  42nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase (DHFR) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023897(4-tert-Butylcarbamoyl-2-{4-[(2,4-diamino-pteridin-...)
Affinity DataIC50:  44nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase (DHFR) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023898(4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diam...)
Affinity DataIC50:  45nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase (DHFR) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023717(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  45nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50022330(5-(2-Bromo-acetylamino)-2-{4-[(2,4-diamino-pteridi...)
Affinity DataIC50:  46nMAssay Description:Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity of the compound towards dihydrofolate reductase in L1210 murine leukemia cell linesMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50011320(CHEMBL18155 | N-(4-Carboxy-4-{4-[(2,4-diamino-pter...)
Affinity DataIC50:  52nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from mouse cells (L1210/R71).More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50011320(CHEMBL18155 | N-(4-Carboxy-4-{4-[(2,4-diamino-pter...)
Affinity DataIC50:  52nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023716(5-Acetylamino-2-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Affinity DataIC50:  53nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023714(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-ami...)
Affinity DataIC50:  56nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023899(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  57nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase ( DHFR ) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023894(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  60nMAssay Description:Compound was tested for its inhibitory concentration to inhibit the enzyme Dihydro Folate Reductase (DHFR) from murine L1210 leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50041671(2-{4-[3-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopen...)
Affinity DataIC50:  60nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in P388 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023707(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  63nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) in mouse L1210 leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50019388(6-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)
Affinity DataIC50:  65nMAssay Description:Compound was tested for its ability to inhibit purified dihydrofolate reductase(DHFR) from L1210/R81 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50023705(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  67nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) in mouse L1210 leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Institute

Curated by ChEMBL
LigandPNGBDBM50020104(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  67nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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