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Compile Data Set for Download or QSAR

Found 40 hits of affinity data for UniProtKB/TrEMBL: Q16552   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-17A


(Homo sapiens (Human))
BDBM419139
PNG
(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419139
PNG
(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419256
PNG
(N-(2,4-dimethylphenyl)-N- isobutyl-3-(S- methylsul...)
Show SMILES CC(C)CN(c1ccc(C)cc1C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-18(2)16-27(23-8-6-19(3)14-20(23)4)34(29,30)22-7-9-24(25(15-22)33(5,26)28)32-17-21-10-12-31-13-11-21/h6-9,14-15,18,21,26H,10-13,16-17H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419252
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncn2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H31N5O3S2/c1-5-19-6-8-21(9-7-19)29(16-18(2)3)34(31,32)22-10-11-23(24(14-22)33(4,25)30)27-15-20-12-13-26-17-28-20/h6-14,17-18,25,27H,5,15-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461076
PNG
(CHEMBL4227214 | US10457637, Compound 124)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CC)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C27H41N3O4S2/c1-6-22-8-10-23(11-9-22)30(19-21(3)4)36(32,33)24-12-13-25(26(18-24)35(5,28)31)29-20-27(7-2)14-16-34-17-15-27/h8-13,18,21,28-29H,6-7,14-17,19-20H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419242
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C23H33N3O4S2/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419234
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H35N3O4S2/c1-5-20-6-8-21(9-7-20)28(15-19(2)3)34(30,31)22-10-11-23(24(14-22)33(4,26)29)27-13-12-25(16-27)17-32-18-25/h6-11,14,19,26H,5,12-13,15-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419225
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CSC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C23H33N3O3S3/c1-5-18-6-8-20(9-7-18)26(14-17(2)3)32(28,29)21-10-11-22(23(12-21)31(4,24)27)25-13-19-15-30-16-19/h6-12,17,19,24-25H,5,13-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419218
PNG
(4-((((1R,5S,6S)-3- oxabicyclo[3.1.0]hexan-6- yl)me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H35N3O4S2/c1-5-18-6-8-19(9-7-18)28(14-17(2)3)34(30,31)20-10-11-24(25(12-20)33(4,26)29)27-13-21-22-15-32-16-23(21)22/h6-12,17,21-23,26-27H,5,13-16H2,1-4H3/t21-,22-,23+,33?
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419214
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCSCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C23H33N3O3S3/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461069
PNG
(CHEMBL4228522 | US10457637, Compound 66)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C24H34N2O6S2/c1-4-19-5-7-21(8-6-19)26(16-18(2)3)34(29,30)22-9-10-23(24(15-22)33(25,27)28)32-17-20-11-13-31-14-12-20/h5-10,15,18,20H,4,11-14,16-17H2,1-3H3,(H2,25,27,28)
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419192
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncc2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H32N4O3S2/c1-5-20-6-8-22(9-7-20)29(18-19(2)3)34(31,32)23-10-11-24(25(16-23)33(4,26)30)28-17-21-12-14-27-15-13-21/h6-16,19,26,28H,5,17-18H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461083
PNG
(CHEMBL4225889 | US10457637, Compound 62)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36FN3O4S2/c1-5-20-6-8-21(9-7-20)29(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,27)30)28-18-25(26)12-14-33-15-13-25/h6-11,16,19,27-28H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419189
PNG
(N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC(O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H35N3O4S2/c1-5-18-6-8-20(9-7-18)27(16-17(2)3)33(30,31)22-10-11-23(24(14-22)32(4,25)29)26-15-19-12-21(28)13-19/h6-11,14,17,19,21,25-26,28H,5,12-13,15-16H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461075
PNG
(CHEMBL4225072 | US10457637, Compound 55)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(C)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)35(31,32)23-11-12-24(25(17-23)34(5,27)30)28-19-26(4)13-15-33-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461066
PNG
(CHEMBL4228566 | US10457637, Compound 53)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N(C)CC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28(4)19-22-13-15-33-16-14-22/h7-12,17,20,22,27H,6,13-16,18-19H2,1-5H3
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461074
PNG
(CHEMBL4227729 | US10457637, Compound 52)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-20-6-8-22(9-7-20)28(18-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)27-17-21-12-14-32-15-13-21/h6-11,16,19,21,26-27H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461063
PNG
(CHEMBL4226803 | US10457637, Compound 8)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461065
PNG
(CHEMBL4225020 | US10457637, Compound 18)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=N)(=O)CC
Show InChI InChI=1S/C26H38N2O5S2/c1-5-21-7-9-23(10-8-21)28(18-20(3)4)35(30,31)24-11-12-25(26(17-24)34(27,29)6-2)33-19-22-13-15-32-16-14-22/h7-12,17,20,22,27H,5-6,13-16,18-19H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419154
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)=O
Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419155
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)=O
Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419157
PNG
(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)c(CO)c1
Show InChI InChI=1S/C25H35NO4S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461068
PNG
(CHEMBL4228069 | US10457637, Compound 24)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H35NO6S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,27)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419162
PNG
(N-(4-ethylphenyl)-4-((4- fluorotetrahydro-2H-pyran...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H35FN2O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(30,31)22-10-11-23(24(16-22)34(4,27)29)33-18-25(26)12-14-32-15-13-25/h6-11,16,19,27H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419235
PNG
(4-(2,2-dioxido-2-thia-6- azaspiro[3.3]heptan-6-yl)...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(C2)CS(=O)(=O)C3)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H33N3O5S3/c1-5-19-6-8-20(9-7-19)27(13-18(2)3)35(31,32)21-10-11-22(23(12-21)33(4,25)28)26-14-24(15-26)16-34(29,30)17-24/h6-12,18,25H,5,13-17H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419257
PNG
(N-isopropyl-N-(4-methoxy- 2-methylphenyl)-3-(S- me...)
Show SMILES COc1ccc(N(C(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)c(c2)S(C)(=N)=O)c(C)c1
Show InChI InChI=1S/C24H34N2O6S2/c1-17(2)26(22-8-6-20(30-4)14-18(22)3)34(28,29)21-7-9-23(24(15-21)33(5,25)27)32-16-19-10-12-31-13-11-19/h6-9,14-15,17,19,25H,10-13,16H2,1-5H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419253
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H35N3O4S2/c1-5-20-7-9-21(10-8-20)27(18-19(2)3)33(29,30)22-11-12-23(24(17-22)32(4,25)28)26-13-6-15-31-16-14-26/h7-12,17,19,25H,5-6,13-16,18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419160
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1
Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461079
PNG
(CHEMBL4227543 | US10457637, Compound 65)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(CCN2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-21-6-9-23(10-7-21)28(19-20(2)3)34(30,31)24-11-8-22(25(18-24)33(4,26)29)12-13-27-14-16-32-17-15-27/h6-11,18,20,26H,5,12-17,19H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419158
PNG
(US10457637, Compound 22 | ethanesulfinyl-N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=O)CC
Show InChI InChI=1S/C26H37NO5S2/c1-5-21-7-9-23(10-8-21)27(18-20(3)4)34(29,30)24-11-12-25(26(17-24)33(28)6-2)32-19-22-13-15-31-16-14-22/h7-12,17,20,22H,5-6,13-16,18-19H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419246
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((2- methoxypyrid...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(OC)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H34N4O4S2/c1-6-20-7-9-22(10-8-20)30(18-19(2)3)36(32,33)23-11-12-24(25(16-23)35(5,27)31)29-17-21-13-14-28-26(15-21)34-4/h7-16,19,27,29H,6,17-18H2,1-5H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419156
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)=O
Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419222
PNG
(4-(((2-oxaspiro[3.3]heptan- 6-yl)methyl)amino)-N-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H37N3O4S2/c1-5-20-6-8-22(9-7-20)29(16-19(2)3)35(31,32)23-10-11-24(25(12-23)34(4,27)30)28-15-21-13-26(14-21)17-33-18-26/h6-12,19,21,27-28H,5,13-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM50461087
PNG
(CHEMBL4226731 | US10457637, Compound 92)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(O)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,26)30)27-18-25(29)12-14-33-15-13-25/h6-11,16,19,26-27,29H,5,12-15,17-18H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419187
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CNC(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H34N4O4S2/c1-5-18-6-8-20(9-7-18)28(16-17(2)3)34(31,32)21-10-11-22(23(13-21)33(4,25)30)26-14-19-12-24(29)27-15-19/h6-11,13,17,19,25-26H,5,12,14-16H2,1-4H3,(H,27,29)
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419148
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1S/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419148
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1S/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419147
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1S/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419236
PNG
(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H37N3O4S2/c1-5-21-6-8-22(9-7-21)29(17-20(2)3)35(31,32)23-10-11-24(25(16-23)34(4,27)30)28-14-12-26(13-15-28)18-33-19-26/h6-11,16,20,27H,5,12-15,17-19H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Interleukin-17A


(Homo sapiens (Human))
BDBM419196
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)cc1
Show InChI InChI=1S/C24H33NO3S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)30(26,27)24-11-9-23(10-12-24)29-18-21-13-15-28-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair