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Compile Data Set for Download or QSAR

Found 1402 hits of ic50 for UniProtKB: P08482   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor


(RAT)
BDBM50213281
PNG
(CHEMBL351561)
Show SMILES C\C(=C\CO\N=C1/CN2CCC1C2)C#Cc1cccs1
Show InChI InChI=1S/C16H18N2OS/c1-13(4-5-15-3-2-10-20-15)7-9-19-17-16-12-18-8-6-14(16)11-18/h2-3,7,10,14H,6,8-9,11-12H2,1H3/b13-7-,17-16+
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n/an/a 0.0200n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213074
PNG
(CHEMBL156050)
Show SMILES C\C(=C\CO\N=C1/CN2CCC1C2)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C18H19FN2O/c1-14(2-3-15-4-6-17(19)7-5-15)9-11-22-20-18-13-21-10-8-16(18)12-21/h4-7,9,16H,8,10-13H2,1H3/b14-9-,20-18+
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n/an/a 0.0300n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213283
PNG
(CHEMBL350223)
Show SMILES COc1ccc(cc1)C#C\C(C)=C/CO\N=C1/CN2CCC1C2
Show InChI InChI=1S/C19H22N2O2/c1-15(3-4-16-5-7-18(22-2)8-6-16)10-12-23-20-19-14-21-11-9-17(19)13-21/h5-8,10,17H,9,11-14H2,1-2H3/b15-10-,20-19+
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n/an/a 0.100n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213207
PNG
(CHEMBL160582)
Show SMILES C\C(=C\CO\N=C1/CN2CCC1C2)C#Cc1ccccc1
Show InChI InChI=1S/C18H20N2O/c1-15(7-8-16-5-3-2-4-6-16)10-12-21-19-18-14-20-11-9-17(18)13-20/h2-6,10,17H,9,11-14H2,1H3/b15-10-,19-18+
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n/an/a 0.150n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50280622
PNG
(1-(3-Isothiocyanato-phenyl)-3-(4-{4-[2-oxo-2-(6-ox...)
Show SMILES O=C(CN1CCN(CCCCCCCCCCNC(=S)Nc2cccc(c2)N=C=S)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C36H44N8O2S2/c45-33(44-32-17-8-7-15-30(32)35(46)41-31-16-12-19-37-34(31)44)26-43-23-21-42(22-24-43)20-10-6-4-2-1-3-5-9-18-38-36(48)40-29-14-11-13-28(25-29)39-27-47/h7-8,11-17,19,25H,1-6,9-10,18,20-24,26H2,(H,41,46)(H2,38,40,48)
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n/an/a 0.150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated for irreversible inhibition at rat forebrain muscarinic receptor


Bioorg Med Chem Lett 2: 845-850 (1992)


Article DOI: 10.1016/S0960-894X(00)80542-9
BindingDB Entry DOI: 10.7270/Q2F18ZMP
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50280565
PNG
(5-(1-Aza-bicyclo[2.2.1]hept-3-yl)-[1,2,4]oxadiazol...)
Show SMILES Nc1noc(n1)C1CN2CCC1C2
Show InChI InChI=1S/C8H12N4O/c9-8-10-7(13-11-8)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2,(H2,9,11)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex


Bioorg Med Chem Lett 2: 821-826 (1992)


Article DOI: 10.1016/S0960-894X(00)80538-7
BindingDB Entry DOI: 10.7270/Q2PG1RNN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50033155
PNG
(3-(3-Butylsulfanyl-pyrazin-2-yl)-1-aza-bicyclo[2.2...)
Show SMILES CCCCSc1nccnc1C1CN2CCC1CC2
Show InChI InChI=1S/C15H23N3S/c1-2-3-10-19-15-14(16-6-7-17-15)13-11-18-8-4-12(13)5-9-18/h6-7,12-13H,2-5,8-11H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand.


J Med Chem 38: 3469-81 (1995)


Article DOI: 10.1021/jm00018a007
BindingDB Entry DOI: 10.7270/Q2TB17JZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213070
PNG
(CHEMBL405426)
Show SMILES C\C(=C\CO\N=C1\CN2CCC1C2)C#Cc1ccc(Cl)cc1
Show InChI InChI=1S/C18H19ClN2O/c1-14(2-3-15-4-6-17(19)7-5-15)9-11-22-20-18-13-21-10-8-16(18)12-21/h4-7,9,16H,8,10-13H2,1H3/b14-9-,20-18-
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n/an/a 0.450n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50033155
PNG
(3-(3-Butylsulfanyl-pyrazin-2-yl)-1-aza-bicyclo[2.2...)
Show SMILES CCCCSc1nccnc1C1CN2CCC1CC2
Show InChI InChI=1S/C15H23N3S/c1-2-3-10-19-15-14(16-6-7-17-15)13-11-18-8-4-12(13)5-9-18/h6-7,12-13H,2-5,8-11H2,1H3
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n/an/a 0.5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.


J Med Chem 38: 3469-81 (1995)


Article DOI: 10.1021/jm00018a007
BindingDB Entry DOI: 10.7270/Q2TB17JZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213278
PNG
(CHEMBL156445)
Show SMILES COc1cccc(c1)C#C\C(C)=C/CO\N=C1/CN2CCC1C2
Show InChI InChI=1S/C19H22N2O2/c1-15(6-7-16-4-3-5-18(12-16)22-2)9-11-23-20-19-14-21-10-8-17(19)13-21/h3-5,9,12,17H,8,10-11,13-14H2,1-2H3/b15-9-,20-19+
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n/an/a 0.520n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062577
PNG
(6-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CC1CCC2
Show InChI InChI=1S/C12H19N3OS2/c1-2-6-17-12-11(13-18-14-12)16-10-8-15-5-3-4-9(10)7-15/h9-10H,2-8H2,1H3
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n/an/a 0.550n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213077
PNG
(CHEMBL348412)
Show SMILES C\C(=C\CO\N=C1/CN2CCC1C2)C#Cc1ccc(C)cc1
Show InChI InChI=1S/C19H22N2O/c1-15-3-6-17(7-4-15)8-5-16(2)10-12-22-20-19-14-21-11-9-18(19)13-21/h3-4,6-7,10,18H,9,11-14H2,1-2H3/b16-10-,20-19+
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n/an/a 0.570n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50033162
PNG
(3-(3-Pentylsulfanyl-pyrazin-2-yl)-1-aza-bicyclo[2....)
Show SMILES CCCCCSc1nccnc1C1CN2CCC1CC2
Show InChI InChI=1S/C16H25N3S/c1-2-3-4-11-20-16-15(17-7-8-18-16)14-12-19-9-5-13(14)6-10-19/h7-8,13-14H,2-6,9-12H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.


J Med Chem 38: 3469-81 (1995)


Article DOI: 10.1021/jm00018a007
BindingDB Entry DOI: 10.7270/Q2TB17JZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50070692
PNG
(CHEMBL99240)
Show SMILES CCCCCCOc1nsnc1[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C34H50N8O8/c1-3-20(2)28(42-30(46)24(12-7-8-16-35)39-29(45)23-19-22(43)14-15-27(23)44)32(48)41-26(18-21-10-5-4-6-11-21)31(47)40-25(33(49)50)13-9-17-38-34(36)37/h4-6,10-11,14-15,19-20,24-26,28,43-44H,3,7-9,12-13,16-18,35H2,1-2H3,(H,39,45)(H,40,47)(H,41,48)(H,42,46)(H,49,50)(H4,36,37,38)/t20?,24-,25-,26-,28-/m0/s1
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n/an/a 0.730n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50291551
PNG
(CHEMBL274329 | Trimethyl-[4-(3-oxo-isoxazolidin-2-...)
Show SMILES C[N+](C)(C)CC#CCN1OCCC1=O
Show InChI InChI=1S/C10H17N2O2/c1-12(2,3)8-5-4-7-11-10(13)6-9-14-11/h6-9H2,1-3H3/q+1
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n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Muscarinic receptor M2 in rat heart using [3H]-QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a co...


Bioorg Med Chem Lett 7: 1033-1036 (1997)


Article DOI: 10.1016/S0960-894X(97)00150-9
BindingDB Entry DOI: 10.7270/Q2S46RZ2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213286
PNG
(CHEMBL346580)
Show SMILES C\C(=C/CO\N=C1/CN2CCC1C2)C#Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H18Cl2N2O/c1-13(2-3-14-4-5-16(19)17(20)10-14)7-9-23-21-18-12-22-8-6-15(18)11-22/h4-5,7,10,15H,6,8-9,11-12H2,1H3/b13-7+,21-18+
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TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50072214
PNG
((R)-3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiaz...)
Show SMILES C(Oc1nsnc1[C@H]1CN2CCC1C2)C#Cc1ccccc1
Show InChI InChI=1S/C17H17N3OS/c1-2-5-13(6-3-1)7-4-10-21-17-16(18-22-19-17)15-12-20-9-8-14(15)11-20/h1-3,5-6,14-15H,8-12H2/t14?,15-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006582
PNG
(1-Methyl-5-(4-propylsulfanyl-[1,2,5]thiadiazol-3-y...)
Show SMILES CCCSc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3S2/c1-3-7-15-11-10(12-16-13-11)9-5-4-6-14(2)8-9/h5H,3-4,6-8H2,1-2H3
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n/an/a 0.900n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50065207
PNG
(1-Aza-bicyclo[2.2.1]heptan-3-one O-((Z)-3-methyl-p...)
Show SMILES C\C(=C\CO\N=C1/CN2CCC1C2)C#C
Show InChI InChI=1S/C12H16N2O/c1-3-10(2)5-7-15-13-12-9-14-6-4-11(12)8-14/h1,5,11H,4,6-9H2,2H3/b10-5-,13-12+
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213279
PNG
(CHEMBL345415)
Show SMILES C\C(=C\CO\N=C1\CN2CCC1C2)C#Cc1ccccc1
Show InChI InChI=1S/C18H20N2O/c1-15(7-8-16-5-3-2-4-6-16)10-12-21-19-18-14-20-11-9-17(18)13-20/h2-6,10,17H,9,11-14H2,1H3/b15-10-,19-18-
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n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50033162
PNG
(3-(3-Pentylsulfanyl-pyrazin-2-yl)-1-aza-bicyclo[2....)
Show SMILES CCCCCSc1nccnc1C1CN2CCC1CC2
Show InChI InChI=1S/C16H25N3S/c1-2-3-4-11-20-16-15(17-7-8-18-16)14-12-19-9-5-13(14)6-10-19/h7-8,13-14H,2-6,9-12H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand.


J Med Chem 38: 3469-81 (1995)


Article DOI: 10.1021/jm00018a007
BindingDB Entry DOI: 10.7270/Q2TB17JZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50070735
PNG
(CHEMBL317324)
Show SMILES CCCCCCOc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2
Show InChI InChI=1S/C29H48N8O8/c1-4-16(3)23(27(43)34-19(5-2)28(44)45)37-26(42)21(10-8-14-33-29(31)32)36-25(41)20(9-6-7-13-30)35-24(40)18-15-17(38)11-12-22(18)39/h11-12,15-16,19-21,23,38-39H,4-10,13-14,30H2,1-3H3,(H,34,43)(H,35,40)(H,36,41)(H,37,42)(H,44,45)(H4,31,32,33)/t16?,19?,20-,21-,23-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50072227
PNG
((1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]t...)
Show SMILES C(Oc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2)C#Cc1ccccc1
Show InChI InChI=1S/C18H19N3OS/c1-2-6-14(7-3-1)8-5-11-22-18-17(19-23-20-18)16-13-21-10-4-9-15(16)12-21/h1-3,6-7,15-16H,4,9-13H2/t15-,16-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50006572
PNG
(5-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-methy...)
Show SMILES CCCCSc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C12H19N3S2/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50070725
PNG
(CHEMBL318403)
Show SMILES CN1CCC=C(C1)c1nsnc1SCCCc1ccccc1
Show InChI InChI=1S/C28H43N5O8/c1-4-16(3)23(26(38)30-19(5-2)28(40)41)32-25(37)21-10-8-14-33(21)27(39)20(9-6-7-13-29)31-24(36)18-15-17(34)11-12-22(18)35/h11-12,15-16,19-21,23,34-35H,4-10,13-14,29H2,1-3H3,(H,30,38)(H,31,36)(H,32,37)(H,40,41)/t16?,19?,20-,21-,23-/m0/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50070647
PNG
(CHEMBL329924)
Show SMILES C(CSc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2)Cc1ccccc1
Show InChI InChI=1S/C18H23N5O/c1-3-6-13-7-4-5-8-14(13)9-15(12(2)24)23-11-22-16-17(19)20-10-21-18(16)23/h4-5,7-8,10-12,15,24H,3,6,9H2,1-2H3,(H2,19,20,21)/t12-,15+/m0/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50003351
PNG
(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Show SMILES CCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C12H19N3OS/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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n/an/a 1.40n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1


J Med Chem 35: 4011-9 (1992)


Article DOI: 10.1021/jm00100a005
BindingDB Entry DOI: 10.7270/Q2KW5F1K
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50003351
PNG
(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Show SMILES CCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C12H19N3OS/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50003351
PNG
(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Show SMILES CCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C12H19N3OS/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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n/an/a 1.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranes


Bioorg Med Chem Lett 2: 809-814 (1992)


Article DOI: 10.1016/S0960-894X(00)80536-3
BindingDB Entry DOI: 10.7270/Q2T72HBX
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213079
PNG
(CHEMBL160928)
Show SMILES COc1ccc(cc1OC)C#C\C(C)=C/CO\N=C1/CN2CCC1C2
Show InChI InChI=1S/C20H24N2O3/c1-15(4-5-16-6-7-19(23-2)20(12-16)24-3)9-11-25-21-18-14-22-10-8-17(18)13-22/h6-7,9,12,17H,8,10-11,13-14H2,1-3H3/b15-9-,21-18+
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TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062579
PNG
(3-(4-Pentylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1S/C14H23N3OS2/c1-2-3-4-9-19-14-13(15-20-16-14)18-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50003351
PNG
(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Show SMILES CCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C12H19N3OS/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50367705
PNG
(SULFOARECOLINE IODIDE)
Show SMILES COC(=O)C1=CCC[S+](C)C1
Show InChI InChI=1S/C8H13O2S/c1-10-8(9)7-4-3-5-11(2)6-7/h4H,3,5-6H2,1-2H3/q+1
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Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor


J Med Chem 31: 1312-6 (1988)


Article DOI: 10.1021/jm00402a010
BindingDB Entry DOI: 10.7270/Q2B27VW2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptor


Bioorg Med Chem Lett 2: 803-808 (1992)


Article DOI: 10.1016/S0960-894X(00)80535-1
BindingDB Entry DOI: 10.7270/Q2Z0382N
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50003369
PNG
(1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,...)
Show SMILES CCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3OS/c1-3-7-15-11-10(12-16-13-11)9-5-4-6-14(2)8-9/h5H,3-4,6-8H2,1-2H3
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n/an/a 1.60n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat hippocampus Muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 4011-9 (1992)


Article DOI: 10.1021/jm00100a005
BindingDB Entry DOI: 10.7270/Q2KW5F1K
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50213071
PNG
(CHEMBL160939)
Show SMILES C\C(=C\CO\N=C1\CN2CCC1C2)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C18H19FN2O/c1-14(2-3-15-4-6-17(19)7-5-15)9-11-22-20-18-13-21-10-8-16(18)12-21/h4-7,9,16H,8,10-13H2,1H3/b14-9-,20-18-
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TBA

Assay Description
Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50223182
PNG
(2-(4-(pyrrolidin-1-yl)but-2-ynyl)isoxazolidin-3-on...)
Show SMILES O=C1CCON1CC#CCN1CCCC1
Show InChI InChI=1S/C11H16N2O2/c14-11-5-10-15-13(11)9-4-3-8-12-6-1-2-7-12/h1-2,5-10H2
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n/an/a 1.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic receptor M2 in rat brain using [3H]-QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM


Bioorg Med Chem Lett 7: 1033-1036 (1997)


Article DOI: 10.1016/S0960-894X(97)00150-9
BindingDB Entry DOI: 10.7270/Q2S46RZ2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50003369
PNG
(1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,...)
Show SMILES CCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3OS/c1-3-7-15-11-10(12-16-13-11)9-5-4-6-14(2)8-9/h5H,3-4,6-8H2,1-2H3
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n/an/a 1.60n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50003369
PNG
(1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,...)
Show SMILES CCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3OS/c1-3-7-15-11-10(12-16-13-11)9-5-4-6-14(2)8-9/h5H,3-4,6-8H2,1-2H3
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Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50070684
PNG
(CHEMBL321073)
Show SMILES C(CSc1nsnc1[C@H]1C[N@@]2CC[C@H]1C2)Cc1ccccc1
Show InChI InChI=1S/C28H43N7O8/c1-4-15(3)22(25(40)32-18(5-2)27(42)43)34-24(39)20-9-7-13-35(20)26(41)19(8-6-12-31-28(29)30)33-23(38)17-14-16(36)10-11-21(17)37/h10-11,14-15,18-20,22,36-37H,4-9,12-13H2,1-3H3,(H,32,40)(H,33,38)(H,34,39)(H,42,43)(H4,29,30,31)/t15?,18?,19-,20-,22-/m0/s1
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Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50072225
PNG
((1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,...)
Show SMILES C(Sc1nsnc1[C@H]1C[N@]2C[C@@H]1CCC2)C#Cc1ccccc1
Show InChI InChI=1S/C18H19N3S2/c1-2-6-14(7-3-1)8-5-11-22-18-17(19-23-20-18)16-13-21-10-4-9-15(16)12-21/h1-3,6-7,15-16H,4,9-13H2/t15-,16-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006572
PNG
(5-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-methy...)
Show SMILES CCCCSc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C12H19N3S2/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3
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Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006574
PNG
(5-(4-Ethylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-methy...)
Show SMILES CCSc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C10H15N3S2/c1-3-14-10-9(11-15-12-10)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor


J Med Chem 31: 1312-6 (1988)


Article DOI: 10.1021/jm00402a010
BindingDB Entry DOI: 10.7270/Q2B27VW2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003369
PNG
(1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,...)
Show SMILES CCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3OS/c1-3-7-15-11-10(12-16-13-11)9-5-4-6-14(2)8-9/h5H,3-4,6-8H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity towards Muscarinic acetylcholine receptor M1 by the displacement of [3H]-pirenzepine in rat cerebral cortical membranes


Bioorg Med Chem Lett 4: 2205-2210 (1994)


Article DOI: 10.1016/S0960-894X(00)80072-4
BindingDB Entry DOI: 10.7270/Q2T72HCC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50002338
PNG
((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Show SMILES CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [3H]quinuclidinyl benzilate (QNB) from Muscarinic acetylcholine receptor in rat brain


J Med Chem 31: 454-61 (1988)


Article DOI: 10.1021/jm00397a032
BindingDB Entry DOI: 10.7270/Q25T3JGG
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003366
PNG
(1-Methyl-5-(4-pentyloxy-[1,2,5]thiadiazol-3-yl)-1,...)
Show SMILES CCCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C13H21N3OS/c1-3-4-5-9-17-13-12(14-18-15-13)11-7-6-8-16(2)10-11/h7H,3-6,8-10H2,1-2H3
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Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50033151
PNG
(3-(3-Hexylsulfanyl-pyrazin-2-yl)-1-aza-bicyclo[2.2...)
Show SMILES CCCCCCSc1nccnc1C1CN2CCC1CC2
Show InChI InChI=1S/C17H27N3S/c1-2-3-4-5-12-21-17-16(18-8-9-19-17)15-13-20-10-6-14(15)7-11-20/h8-9,14-15H,2-7,10-13H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.


J Med Chem 38: 3469-81 (1995)


Article DOI: 10.1021/jm00018a007
BindingDB Entry DOI: 10.7270/Q2TB17JZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003359
PNG
(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.


J Med Chem 38: 3469-81 (1995)


Article DOI: 10.1021/jm00018a007
BindingDB Entry DOI: 10.7270/Q2TB17JZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50003366
PNG
(1-Methyl-5-(4-pentyloxy-[1,2,5]thiadiazol-3-yl)-1,...)
Show SMILES CCCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C13H21N3OS/c1-3-4-5-9-17-13-12(14-18-15-13)11-7-6-8-16(2)10-11/h7H,3-6,8-10H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand


Bioorg Med Chem Lett 8: 2897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00509-5
BindingDB Entry DOI: 10.7270/Q27M08GK
More data for this
Ligand-Target Pair
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