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Found 15 of ec50 for UniProtKB: P30926
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  237nMAssay Description:Positive allosteric modulation of human alpha4beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  286nMAssay Description:Positive allosteric modulation of human alpha2beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  5.00E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  5.00E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  7.10E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369150(CHEMBL1788226)
Affinity DataEC50:  9.00E+3nMAssay Description:Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  1.00E+4nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86544(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)
Affinity DataEC50:  1.50E+4nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86544(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)
Affinity DataEC50:  1.50E+4nMAssay Description:Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM86544(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)
Affinity DataEC50:  2.30E+4nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM86544(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)
Affinity DataEC50:  2.50E+4nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369150(CHEMBL1788226)
Affinity DataEC50:  2.90E+4nMAssay Description:Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50071366(7-Methoxy-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-h...)
Affinity DataEC50:  3.20E+4nMAssay Description:Compound was evaluated for its agonist activity against activated human recombinant Nicotinic acetylcholine receptor alpha4-beta4 in Xenopus OocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed