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Compile Data Set for Download or QSAR

Found 6 hits of affinity data for UniProtKB/TrEMBL: O70305   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ataxin-2


(Mus musculus)
BDBM50539271
PNG
(CHEMBL4643186)
Show SMILES OB(O)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCC(=O)N3Cc3ccccc3)cc2)cc1
Show InChI InChI=1S/C26H27BN2O5/c30-25-15-14-24(29(25)17-20-4-2-1-3-5-20)26(31)28-16-19-8-12-23(13-9-19)34-18-21-6-10-22(11-7-21)27(32)33/h1-13,24,32-33H,14-18H2,(H,28,31)/t24-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 35n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in clea...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Ataxin-2


(Mus musculus)
BDBM50539260
PNG
(CHEMBL4640637)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCC(=O)N3Cc3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H37BN2O5/c1-31(2)32(3,4)40-33(39-31)26-14-10-25(11-15-26)22-38-27-16-12-23(13-17-27)20-34-30(37)28-18-19-29(36)35(28)21-24-8-6-5-7-9-24/h5-17,28H,18-22H2,1-4H3,(H,34,37)/t28-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 50n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in clea...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Ataxin-2


(Mus musculus)
BDBM50539261
PNG
(CHEMBL4635495)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCC(=O)N3Cc3ccc(F)cc3)cc2)cc1
Show InChI InChI=1S/C32H36BFN2O5/c1-31(2)32(3,4)41-33(40-31)25-11-5-24(6-12-25)21-39-27-15-9-22(10-16-27)19-35-30(38)28-17-18-29(37)36(28)20-23-7-13-26(34)14-8-23/h5-16,28H,17-21H2,1-4H3,(H,35,38)/t28-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 120n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in clea...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Ataxin-2


(Mus musculus)
BDBM50539262
PNG
(CHEMBL4641981)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(COc2ccc(CNC(=O)[C@H]3CCC(=O)N3Cc3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H37BN2O5/c1-31(2)32(3,4)40-33(39-31)26-14-10-25(11-15-26)22-38-27-16-12-23(13-17-27)20-34-30(37)28-18-19-29(36)35(28)21-24-8-6-5-7-9-24/h5-17,28H,18-22H2,1-4H3,(H,34,37)/t28-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 180n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in clea...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Ataxin-2


(Mus musculus)
BDBM50539266
PNG
(CHEMBL4634443)
Show SMILES ONC(=O)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCC(=O)N3Cc3ccccc3)cc2)cc1
Show InChI InChI=1S/C27H27N3O5/c31-25-15-14-24(30(25)17-20-4-2-1-3-5-20)27(33)28-16-19-8-12-23(13-9-19)35-18-21-6-10-22(11-7-21)26(32)29-34/h1-13,24,34H,14-18H2,(H,28,33)(H,29,32)/t24-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 700n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in clea...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Ataxin-2


(Mus musculus)
BDBM50539280
PNG
(CHEMBL4649464)
Show SMILES OC(=O)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCCN3Cc3ccc(F)cc3)cc2)cc1
Show InChI InChI=1S/C27H27FN2O4/c28-23-11-5-20(6-12-23)17-30-15-1-2-25(30)26(31)29-16-19-7-13-24(14-8-19)34-18-21-3-9-22(10-4-21)27(32)33/h3-14,25H,1-2,15-18H2,(H,29,31)(H,32,33)/t25-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 800n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in clea...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair