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Compile Data Set for Download or QSAR

Found 6 hits for UniProtKB: P23743   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol kinase alpha/zeta


(Homo sapiens)
BDBM50541810
PNG
(CHEMBL4645744)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(=O)n(C)c2ccc(nc12)C#N
Show InChI InChI=1S/C29H27F2N5O/c1-18-17-36(29(20-4-8-22(30)9-5-20)21-6-10-23(31)11-7-21)19(2)16-35(18)26-14-27(37)34(3)25-13-12-24(15-32)33-28(25)26/h4-14,18-19,29H,16-17H2,1-3H3/t18-,19+/m0/s1
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UniChem
Article
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n/an/a 43n/an/an/an/an/an/a



Therachem Research Medilab, LLC.

Curated by ChEMBL


Assay Description
Inhibition of DGKA/DGKZ in human CD8 cells assessed as induction of CD8 activation by measuring IFNgamma level after 20 hrs by AlphaLISA assay


ACS Med Chem Lett 11: 1083-1085 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00118
More data for this
Ligand-Target Pair
Diacylglycerol kinase alpha


(Homo sapiens)
BDBM50541810
PNG
(CHEMBL4645744)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(=O)n(C)c2ccc(nc12)C#N
Show InChI InChI=1S/C29H27F2N5O/c1-18-17-36(29(20-4-8-22(30)9-5-20)21-6-10-23(31)11-7-21)19(2)16-35(18)26-14-27(37)34(3)25-13-12-24(15-32)33-28(25)26/h4-14,18-19,29H,16-17H2,1-3H3/t18-,19+/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Therachem Research Medilab, LLC.

Curated by ChEMBL


Assay Description
Inhibition of full-length C-terminal His6 tagged TVMV-pFBgate fused human DGKalpha expressed in baculovirus infected Sf9 insect cells using liposome ...


ACS Med Chem Lett 11: 1083-1085 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00118
More data for this
Ligand-Target Pair
Diacylglycerol kinase alpha


(Homo sapiens)
BDBM43868
PNG
(3-[2-[4-[bis(4-fluorophenyl)methylene]piperidino]e...)
Show SMILES Fc1ccc(cc1)C(=C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
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n/an/a 300n/an/an/an/an/an/a



University of Piemonte Orientale

Curated by ChEMBL


Assay Description
Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...


Eur J Med Chem 164: 378-390 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.061
More data for this
Ligand-Target Pair
Diacylglycerol kinase alpha


(Homo sapiens)
BDBM43868
PNG
(3-[2-[4-[bis(4-fluorophenyl)methylene]piperidino]e...)
Show SMILES Fc1ccc(cc1)C(=C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
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n/an/a 300n/an/an/an/an/an/a



University of Piemonte Orientale

Curated by ChEMBL


Assay Description
Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...


Eur J Med Chem 164: 378-390 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.061
More data for this
Ligand-Target Pair
Diacylglycerol kinase alpha


(Homo sapiens)
BDBM50541814
PNG
(CHEMBL4648848)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C(c1ccc(F)cc1)c1ccccc1F)c1cc(=O)n(C)c2ccc(nc12)C#N
Show InChI InChI=1S/C29H27F2N5O/c1-18-17-36(29(20-8-10-21(30)11-9-20)23-6-4-5-7-24(23)31)19(2)16-35(18)26-14-27(37)34(3)25-13-12-22(15-32)33-28(25)26/h4-14,18-19,29H,16-17H2,1-3H3/t18-,19+,29?/m0/s1
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n/an/a 580n/an/an/an/an/an/a



Therachem Research Medilab, LLC.

Curated by ChEMBL


Assay Description
Inhibition of full-length C-terminal His6 tagged TVMV-pFBgate fused human DGKalpha expressed in baculovirus infected Sf9 insect cells using liposome ...


ACS Med Chem Lett 11: 1083-1085 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00118
More data for this
Ligand-Target Pair
Diacylglycerol kinase alpha


(Homo sapiens)
BDBM50541812
PNG
(CHEMBL4647083)
Show SMILES C[C@@H]1CN(CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N
Show InChI InChI=1S/C29H24Cl2N6O/c1-18-17-36(28-24(16-33)29(38)35(2)25-12-11-23(15-32)34-26(25)28)13-14-37(18)27(19-3-7-21(30)8-4-19)20-5-9-22(31)10-6-20/h3-12,18,27H,13-14,17H2,1-2H3/t18-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Therachem Research Medilab, LLC.

Curated by ChEMBL


Assay Description
Inhibition of full-length C-terminal His6 tagged TVMV-pFBgate fused human DGKalpha expressed in baculovirus infected Sf9 insect cells using liposome ...


ACS Med Chem Lett 11: 1083-1085 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00118
More data for this
Ligand-Target Pair