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Compile Data Set for Download or QSAR

Found 6 hits of affinity data for UniProtKB/TrEMBL: P04186   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Mus musculus)
BDBM50540314
PNG
(CHEMBL4639592)
Show SMILES CCO[C@H]1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...


J Med Chem 63: 5697-5722 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01870
More data for this
Ligand-Target Pair
Complement factor B


(Mus musculus)
BDBM160475
PNG
(US10093663, Example 26b | US9682968, Example-26a)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...


J Med Chem 63: 5697-5722 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01870
More data for this
Ligand-Target Pair
Complement factor B


(Mus musculus)
BDBM50540312
PNG
(CHEMBL4641109)
Show SMILES CO[C@H]1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...


J Med Chem 63: 5697-5722 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01870
More data for this
Ligand-Target Pair
Complement factor B


(Mus musculus)
BDBM50540313
PNG
(CHEMBL4644208)
Show SMILES CCO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...


J Med Chem 63: 5697-5722 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01870
More data for this
Ligand-Target Pair
Complement factor B


(Mus musculus)
BDBM160036
PNG
(US10093663, Example 21a | US9682968, Example-21a)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...


J Med Chem 63: 5697-5722 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01870
More data for this
Ligand-Target Pair
Complement factor B


(Mus musculus)
BDBM50540311
PNG
(CHEMBL4646504)
Show SMILES CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...


J Med Chem 63: 5697-5722 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01870
More data for this
Ligand-Target Pair