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Compile Data Set for Download or QSAR

Found 11 hits of affinity data for UniProtKB/TrEMBL: Q8CIM5   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 84


(Mus musculus)
BDBM50548393
PNG
(CHEMBL3716446)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(CCc4ccccn4)cc3CCn12
Show InChI InChI=1S/C24H25N3O4/c28-24-26-23(31-16-20-15-29-11-12-30-20)14-22-21-7-5-17(13-18(21)8-10-27(22)24)4-6-19-3-1-2-9-25-19/h1-3,5,7,9,13-14,20H,4,6,8,10-12,15-16H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 39n/an/an/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduct...


J Med Chem 63: 13526-13545 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50556779
PNG
(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 68n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stim...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50556779
PNG
(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 126n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulat...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50556779
PNG
(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 145n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS bi...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50556779
PNG
(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 316n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS bindin...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50548412
PNG
(CHEMBL4776061)
Show SMILES COc1cc2CCn3c(cc(OCCOc4ccccn4)nc3=O)-c2cc1OC
Show InChI InChI=1S/C21H21N3O5/c1-26-17-11-14-6-8-24-16(15(14)12-18(17)27-2)13-20(23-21(24)25)29-10-9-28-19-5-3-4-7-22-19/h3-5,7,11-13H,6,8-10H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 636n/an/an/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduct...


J Med Chem 63: 13526-13545 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50189549
PNG
(CHEMBL3827756)
Show SMILES CCCCCCSc1nc(O)cc(O)n1
Show InChI InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 13n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid ...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50189549
PNG
(CHEMBL3827756)
Show SMILES CCCCCCSc1nc(O)cc(O)n1
Show InChI InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)
UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 26n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liq...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50239172
PNG
(CHEMBL4088884)
Show SMILES Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1
Show InChI InChI=1S/C17H10F4N2/c18-10-2-12-8(6-22-16(12)14(20)4-10)1-9-7-23-17-13(9)3-11(19)5-15(17)21/h2-7,22-23H,1H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 295n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50189549
PNG
(CHEMBL3827756)
Show SMILES CCCCCCSc1nc(O)cc(O)n1
Show InChI InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 30n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair
G-protein coupled receptor 84


(Mus musculus)
BDBM50239172
PNG
(CHEMBL4088884)
Show SMILES Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1
Show InChI InChI=1S/C17H10F4N2/c18-10-2-12-8(6-22-16(12)14(20)4-10)1-9-7-23-17-13(9)3-11(19)5-15(17)21/h2-7,22-23H,1H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 178n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liq...


J Med Chem 63: 15399-15409 (2020)

More data for this
Ligand-Target Pair