BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 10 hits of affinity data for UniProtKB/TrEMBL: Q96GW9   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553183
PNG
(CHEMBL4791458)
Show SMILES CCn1c(Cc2ccc(Cl)cc2Cl)cn(Cc2nc3nc(Cl)ccc3[nH]2)c1=O
Show InChI InChI=1S/C19H16Cl3N5O/c1-2-27-13(7-11-3-4-12(20)8-14(11)21)9-26(19(27)28)10-17-23-15-5-6-16(22)24-18(15)25-17/h3-6,8-9H,2,7,10H2,1H3,(H,23,24,25)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 42n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553184
PNG
(CHEMBL4781504)
Show SMILES CCn1c(Cc2ccc(Cl)cc2Cl)cn(Cc2nc3nc(F)ccc3[nH]2)c1=O
Show InChI InChI=1S/C19H16Cl2FN5O/c1-2-27-13(7-11-3-4-12(20)8-14(11)21)9-26(19(27)28)10-17-23-15-5-6-16(22)24-18(15)25-17/h3-6,8-9H,2,7,10H2,1H3,(H,23,24,25)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 290n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553185
PNG
(CHEMBL4742903)
Show SMILES FC(F)Cn1c(Cc2ccc(Cl)cc2Cl)cn(Cc2nc3nc(Cl)ccc3[nH]2)c1=O
Show InChI InChI=1S/C19H14Cl3F2N5O/c20-11-2-1-10(13(21)6-11)5-12-7-28(19(30)29(12)8-16(23)24)9-17-25-14-3-4-15(22)26-18(14)27-17/h1-4,6-7,16H,5,8-9H2,(H,25,26,27)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 430n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553186
PNG
(CHEMBL4777699)
Show SMILES FC(F)Cn1c(Cc2ccc(Cl)cc2Cl)cn(Cc2nc3nc(F)ccc3[nH]2)c1=O
Show InChI InChI=1S/C19H14Cl2F3N5O/c20-11-2-1-10(13(21)6-11)5-12-7-28(19(30)29(12)8-15(22)23)9-17-25-14-3-4-16(24)26-18(14)27-17/h1-4,6-7,15H,5,8-9H2,(H,25,26,27)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 175n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553193
PNG
(CHEMBL4795266)
Show SMILES COc1cc(Cl)c(cc1OC)-c1cccc2nc(Cc3nc4nc(F)ccc4[nH]3)cn12
Show InChI InChI=1S/C22H17ClFN5O2/c1-30-17-9-13(14(23)10-18(17)31-2)16-4-3-5-21-25-12(11-29(16)21)8-20-26-15-6-7-19(24)27-22(15)28-20/h3-7,9-11H,8H2,1-2H3,(H,26,27,28)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 316n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553188
PNG
(CHEMBL4757779)
Show SMILES CCn1c(Cc2ccc(OC)cc2Cl)cn(Cc2nc3nc(Cl)ccc3[nH]2)c1=O
Show InChI InChI=1S/C20H19Cl2N5O2/c1-3-27-13(8-12-4-5-14(29-2)9-15(12)21)10-26(20(27)28)11-18-23-16-6-7-17(22)24-19(16)25-18/h4-7,9-10H,3,8,11H2,1-2H3,(H,23,24,25)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
PDB
UniChem
PubMed
n/an/an/an/a 39n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553189
PNG
(CHEMBL4762630)
Show SMILES CCn1c(Cc2ccc(OC)cc2Cl)cn(Cc2nc3nc(F)ccc3[nH]2)c1=O
Show InChI InChI=1S/C20H19ClFN5O2/c1-3-27-13(8-12-4-5-14(29-2)9-15(12)21)10-26(20(27)28)11-18-23-16-6-7-17(22)24-19(16)25-18/h4-7,9-10H,3,8,11H2,1-2H3,(H,23,24,25)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 75n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553190
PNG
(CHEMBL4740481)
Show SMILES COc1cc(c(Cl)cc1Cl)-c1cccc2nc(Cc3nc4nc(Cl)ccc4[nH]3)cn12
Show InChI InChI=1S/C21H14Cl3N5O/c1-30-17-8-12(13(22)9-14(17)23)16-3-2-4-20-25-11(10-29(16)20)7-19-26-15-5-6-18(24)27-21(15)28-19/h2-6,8-10H,7H2,1H3,(H,26,27,28)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 507n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553191
PNG
(CHEMBL4745092)
Show SMILES COc1cc(Cl)c(cc1OC)-c1cccc2nc(Cc3nc4nc(Cl)ccc4[nH]3)cn12
Show InChI InChI=1S/C22H17Cl2N5O2/c1-30-17-9-13(14(23)10-18(17)31-2)16-4-3-5-21-25-12(11-29(16)21)8-20-26-15-6-7-19(24)27-22(15)28-20/h3-7,9-11H,8H2,1-2H3,(H,26,27,28)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 478n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair
Methionine--tRNA ligase, mitochondrial


(Homo sapiens)
BDBM50553187
PNG
(CHEMBL4761163)
Show SMILES CCCn1c(Cc2ccc(Cl)cc2Cl)cn(Cc2nc3nc(F)ccc3[nH]2)c1=O
Show InChI InChI=1S/C20H18Cl2FN5O/c1-2-7-28-14(8-12-3-4-13(21)9-15(12)22)10-27(20(28)29)11-18-24-16-5-6-17(23)25-19(16)26-18/h3-6,9-10H,2,7-8,11H2,1H3,(H,24,25,26)
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 195n/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISA


RSC Med Chem 11: 885-895 (2020)

More data for this
Ligand-Target Pair