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Compile Data Set for Download or QSAR

Found 5 hits for UniProtKB: Q13422   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA-binding protein Ikaros


(Homo sapiens)
BDBM526270
PNG
(US11185537, Compound Mix)
Show SMILES OC=O.CN[C@H]1CC=CC[C@@H]1N(C)c1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O
Show InChI InChI=1S/C21H26N4O3.CH2O2/c1-22-16-5-3-4-6-17(16)24(2)14-7-8-15-13(11-14)12-25(21(15)28)18-9-10-19(26)23-20(18)27;2-1-3/h3-4,7-8,11,16-18,22H,5-6,9-10,12H2,1-2H3,(H,23,26,27);1H,(H,2,3)/t16-,17-,18?;/m0./s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 120n/an/an/an/a



Novartis AG

US Patent


Assay Description
The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...


US Patent US11185537 (2021)

More data for this
Ligand-Target Pair
DNA-binding protein Ikaros


(Homo sapiens)
BDBM526271
PNG
(2-(2,6-dioxopiperidin-3- yl)-5-(methyl((1S,2S)-2- ...)
Show SMILES CN[C@H]1CCCC[C@@H]1N(C)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1
Show InChI InChI=1S/C21H26N4O4/c1-22-15-5-3-4-6-16(15)24(2)12-7-8-13-14(11-12)21(29)25(20(13)28)17-9-10-18(26)23-19(17)27/h7-8,11,15-17,22H,3-6,9-10H2,1-2H3,(H,23,26,27)/t15-,16-,17?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 290n/an/an/an/a



Novartis AG

US Patent


Assay Description
The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...


US Patent US11185537 (2021)

More data for this
Ligand-Target Pair
DNA-binding protein Ikaros


(Homo sapiens)
BDBM526278
PNG
(3-(4-fluoro-5-(methyl((1S,2S)-2- (methylamino)cycl...)
Show SMILES CN[C@H]1CCCC[C@@H]1N(C)c1ccc2C(=O)N(Cc2c1F)C1CCC(=O)NC1=O
Show InChI InChI=1S/C21H27FN4O3/c1-23-14-5-3-4-6-15(14)25(2)16-8-7-12-13(19(16)22)11-26(21(12)29)17-9-10-18(27)24-20(17)28/h7-8,14-15,17,23H,3-6,9-11H2,1-2H3,(H,24,27,28)/t14-,15-,17?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 570n/an/an/an/a



Novartis AG

US Patent


Assay Description
The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...


US Patent US11185537 (2021)

More data for this
Ligand-Target Pair
DNA-binding protein Ikaros


(Homo sapiens)
BDBM526270
PNG
(US11185537, Compound Mix)
Show SMILES OC=O.CN[C@H]1CC=CC[C@@H]1N(C)c1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O
Show InChI InChI=1S/C21H26N4O3.CH2O2/c1-22-16-5-3-4-6-17(16)24(2)14-7-8-15-13(11-14)12-25(21(15)28)18-9-10-19(26)23-20(18)27;2-1-3/h3-4,7-8,11,16-18,22H,5-6,9-10,12H2,1-2H3,(H,23,26,27);1H,(H,2,3)/t16-,17-,18?;/m0./s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 630n/an/an/an/a



Novartis AG

US Patent


Assay Description
The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...


US Patent US11185537 (2021)

More data for this
Ligand-Target Pair
DNA-binding protein Ikaros


(Homo sapiens)
BDBM526273
PNG
(2-(2,6-dioxopiperidin-3-yl)-5-(((1S,2S)-2- (ethyla...)
Show SMILES CCN[C@H]1CCCC[C@@H]1N(C)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1
Show InChI InChI=1S/C22H28N4O4/c1-3-23-16-6-4-5-7-17(16)25(2)13-8-9-14-15(12-13)22(30)26(21(14)29)18-10-11-19(27)24-20(18)28/h8-9,12,16-18,23H,3-7,10-11H2,1-2H3,(H,24,27,28)/t16-,17-,18?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 51n/an/an/an/a



Novartis AG

US Patent


Assay Description
The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...


US Patent US11185537 (2021)

More data for this
Ligand-Target Pair