Compile Data Set for Download or QSAR

Found 16 hits of affinity data for UniProtKB/TrEMBL: Q5JUK3   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557676 (CHEMBL4763955) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C1CC1 Show InChI InChI=1S/C18H17F3N6O2/c1-9(23-16(28)13-8-14(18(19,20)21)25-27(13)2)17-24-15(26-29-17)11-5-6-22-12(7-11)10-3-4-10/h5-10H,3-4H2,1-2H3,(H,23,28)/t9-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557672 (CHEMBL4788669) Show SMILES COc1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C16H15F3N6O3/c1-8(21-14(26)10-7-11(16(17,18)19)23-25(10)2)15-22-13(24-28-15)9-4-5-20-12(6-9)27-3/h4-8H,1-3H3,(H,21,26)/t8-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557680 (CHEMBL4741793) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C16H12F6N6O2/c1-7(24-13(29)9-6-11(16(20,21)22)26-28(9)2)14-25-12(27-30-14)8-3-4-23-10(5-8)15(17,18)19/h3-7H,1-2H3,(H,24,29)/t7-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557678 (CHEMBL4754084) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)F Show InChI InChI=1S/C16H13F5N6O2/c1-7(23-14(28)10-6-11(16(19,20)21)25-27(10)2)15-24-13(26-29-15)8-3-4-22-9(5-8)12(17)18/h3-7,12H,1-2H3,(H,23,28)/t7-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557660 (CHEMBL4783741) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1cccc(F)c1 Show InChI InChI=1S/C16H13F4N5O2/c1-8(15-22-13(24-27-15)9-4-3-5-10(17)6-9)21-14(26)11-7-12(16(18,19)20)23-25(11)2/h3-8H,1-2H3,(H,21,26)/t8-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557666 (CHEMBL4786255) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(C)c1 Show InChI InChI=1S/C16H15F3N6O2/c1-8-6-10(4-5-20-8)13-22-15(27-24-13)9(2)21-14(26)11-7-12(16(17,18)19)23-25(11)3/h4-7,9H,1-3H3,(H,21,26)/t9-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557652 (CHEMBL4793291) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C1CC1)c1nc(no1)-c1cccc(C)c1 Show InChI InChI=1S/C19H21N5O2/c1-11-5-4-6-14(9-11)17-21-19(26-23-17)12(2)20-18(25)16-10-15(13-7-8-13)22-24(16)3/h4-6,9-10,12-13H,7-8H2,1-3H3,(H,20,25)/t12-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557679 (CHEMBL4793279) Show SMILES CNc1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C16H16F3N7O2/c1-8(22-14(27)10-7-11(16(17,18)19)24-26(10)3)15-23-13(25-28-15)9-4-5-21-12(6-9)20-2/h4-8H,1-3H3,(H,20,21)(H,22,27)/t8-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557677 (CHEMBL4750925) Show SMILES COCc1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C17H17F3N6O3/c1-9(22-15(27)12-7-13(17(18,19)20)24-26(12)2)16-23-14(25-29-16)10-4-5-21-11(6-10)8-28-3/h4-7,9H,8H2,1-3H3,(H,22,27)/t9-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	322	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557656 (CHEMBL4783466) Show SMILES CCc1cc(C(=O)N[C@@H](C)c2nc(no2)-c2cccc(C)c2)n(C)n1 Show InChI InChI=1S/C18H21N5O2/c1-5-14-10-15(23(4)21-14)17(24)19-12(3)18-20-16(22-25-18)13-8-6-7-11(2)9-13/h6-10,12H,5H2,1-4H3,(H,19,24)/t12-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	335	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557674 (CHEMBL4795194) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)N(C)C Show InChI InChI=1S/C17H18F3N7O2/c1-9(22-15(28)11-8-12(17(18,19)20)24-27(11)4)16-23-14(25-29-16)10-5-6-21-13(7-10)26(2)3/h5-9H,1-4H3,(H,22,28)/t9-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	454	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557675 (CHEMBL4743249) Show SMILES COc1cc(cc(C)n1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C17H17F3N6O3/c1-8-5-10(6-13(21-8)28-4)14-23-16(29-25-14)9(2)22-15(27)11-7-12(17(18,19)20)24-26(11)3/h5-7,9H,1-4H3,(H,22,27)/t9-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	505	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557673 (CHEMBL4781553) Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)N1CCCC1 Show InChI InChI=1S/C19H20F3N7O2/c1-11(24-17(30)13-10-14(19(20,21)22)26-28(13)2)18-25-16(27-31-18)12-5-6-23-15(9-12)29-7-3-4-8-29/h5-6,9-11H,3-4,7-8H2,1-2H3,(H,24,30)/t11-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	573	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557682 (CHEMBL4745211) Show SMILES CO[C@@H](C)c1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C18H19F3N6O3/c1-9(23-16(28)13-8-14(18(19,20)21)25-27(13)3)17-24-15(26-30-17)11-5-6-22-12(7-11)10(2)29-4/h5-10H,1-4H3,(H,23,28)/t9-,10-/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	744	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557683 (CHEMBL4758890) Show SMILES CO[C@H](C)c1cc(ccn1)-c1noc(n1)[C@H](C)NC(=O)c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C18H19F3N6O3/c1-9(23-16(28)13-8-14(18(19,20)21)25-27(13)3)17-24-15(26-30-17)11-5-6-22-12(7-11)10(2)29-4/h5-10H,1-4H3,(H,23,28)/t9-,10+/m0/s1	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	778	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair
Potassium channel subfamily T member 1 (Homo sapiens)	BDBM50557659 (CHEMBL4779088) Show SMILES CC(NC(=O)c1cc(nn1C)C(F)(F)F)c1noc(n1)-c1cccc(C)c1 Show InChI InChI=1S/C17H16F3N5O2/c1-9-5-4-6-11(7-9)16-22-14(24-27-16)10(2)21-15(26)12-8-13(17(18,19)20)23-25(12)3/h4-8,10H,1-3H3,(H,21,26)	PDB NCI pathway Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	977	n/a	n/a	n/a	n/a	n/a	n/a
Praxis Precision Medicines Curated by ChEMBL					Assay Description Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay				ACS Med Chem Lett 12: 593-602 (2021)
					More data for this Ligand-Target Pair