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Found 2108 of ic50 for UniProtKB: P12527
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042977(1-(2,5-Diethoxy-phenyl)-3-(3,4-dihydroxy-phenyl)-p...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042951(3-(3,4-Dihydroxy-phenyl)-1-(5-ethoxy-2-methoxy-phe...)
Affinity DataIC50:  3.80nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042962((E)-3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-phenyl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042962((E)-3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-phenyl)-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042981(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-5-isopropyl-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042979(3-(3,4-Dihydroxy-phenyl)-1-(3-hydroxy-phenyl)-prop...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042979(3-(3,4-Dihydroxy-phenyl)-1-(3-hydroxy-phenyl)-prop...)
Affinity DataIC50:  4.20nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50406422(CHEMBL2115381)
Affinity DataIC50:  4.30nMAssay Description:Reduction of lipid peroxide formed in rat brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042949((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042949((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)
Affinity DataIC50:  4.60nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042964(3-(3,4-Dihydroxy-phenyl)-1-(4-dimethylamino-phenyl...)
Affinity DataIC50:  4.70nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50283416(4-[7-(2,3-Dihydroxy-phenyl)-heptyloxy]-2-hydroxy-3...)
Affinity DataIC50:  5nMAssay Description:Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  5nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in rat RBL-2H3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042971(3-(3,4-Dihydroxy-phenyl)-1-(5-ethoxy-2-hydroxy-phe...)
Affinity DataIC50:  5.30nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50283408(4-[5-(2,3-Dihydroxy-phenyl)-pentyloxy]-2-hydroxy-3...)
Affinity DataIC50:  6nMAssay Description:Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042945(3-(3,4-Dihydroxy-phenyl)-1-(3-methoxy-phenyl)-prop...)
Affinity DataIC50:  6.5nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  6.90nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042968(3-(3,4-Dihydroxy-phenyl)-1-(2,5-dimethoxy-phenyl)-...)
Affinity DataIC50:  7.80nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50000534(2-Phenethyl-6-[3-(pyridin-4-ylsulfanyl)-propyl]-2,...)
Affinity DataIC50:  8nMAssay Description:Tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50010968(3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyc...)
Affinity DataIC50:  8nMAssay Description:The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042973(1-(4-Chloro-phenyl)-3-(3,4-dihydroxy-phenyl)-prope...)
Affinity DataIC50:  8.5nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042991(3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-3-methoxy-ph...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025312(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-(3-...)
Affinity DataIC50:  9nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042960(3-(3,4-Dihydroxy-phenyl)-1-(3-dimethylamino-phenyl...)
Affinity DataIC50:  9.80nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  10nMAssay Description:Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50076649(CHEMBL369848 | N-{1-methyl-3-[1-(4-methoxyphenyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50048999(CHEMBL82292 | N-Hydroxy-N-methyl-3-(11-oxo-6,11-di...)
Affinity DataIC50:  10nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042950(3-(3,4-Dihydroxy-phenyl)-1-(2,4-dimethoxy-phenyl)-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50012730(5-(1-Hydroxy-naphthalen-2-yl)-pentanoic acid ethyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of 5-lipoxygenase in Rattus norvegicus Rat basophil leukemia cells (RBL) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50012730(5-(1-Hydroxy-naphthalen-2-yl)-pentanoic acid ethyl...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025322(6-Decyloxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-me...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025315(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-oct...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042952(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-5-isopropoxy...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025291(2-(3,4-Dihydroxy-phenyl)-6-hexyloxy-5,7-dimethoxy-...)
Affinity DataIC50:  14nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042953(3-(3,4-Dihydroxy-phenyl)-1-(5-isopropoxy-2-methoxy...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042972(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-4-methoxy-ph...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025286(2-(3,4-Dihydroxy-phenyl)-5-hexyloxy-6,7-dimethoxy-...)
Affinity DataIC50:  15nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025278(6-Butoxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-meth...)
Affinity DataIC50:  15nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50041161(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Affinity DataIC50:  16nMAssay Description:Tested for inhibition of 5-HPETE production by rat 5-LO; value ranges from 16-36 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50045673(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Affinity DataIC50:  16nMAssay Description:In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025328(2-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-5-(3-methyl...)
Affinity DataIC50:  16nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042990((E)-3-(3'',4''-Dihydroxyphenyl)-1-(3',4',5'-trimet...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042989(3-(3,4-Dihydroxy-phenyl)-1-(2,5-dimethyl-phenyl)-p...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50041161(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Affinity DataIC50:  17nMAssay Description:In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50408417(CHEMBL2113724)
Affinity DataIC50:  17nMAssay Description:Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025307(6-Decyloxy-2-(3,4-dihydroxy-phenyl)-5,7-dimethoxy-...)
Affinity DataIC50:  17nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50000536(6-Allyl-2-phenethyl-2,3-dihydro-benzofuran-5-ol | ...)
Affinity DataIC50:  17nMAssay Description:Tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042959(3-(3,4-Dihydroxy-phenyl)-1-(2,4-dimethyl-phenyl)-p...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042985(3-(3,4-Dihydroxy-phenyl)-1-(3,4-dimethoxy-phenyl)-...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50025314(2-(3,4-Dihydroxy-phenyl)-5-dodecyloxy-6,7-dimethox...)
Affinity DataIC50:  18nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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