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Compile Data Set for Download or QSAR

Found 30 hits for UniProtKB: Q08462   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144001
PNG
(3-{4-[1-(2',4'-Dichloro-biphenyl-4-ylcarbamoyl)-he...)
Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C30H32Cl2N2O5/c1-2-3-4-5-6-27(39-24-14-9-21(10-15-24)29(37)33-18-17-28(35)36)30(38)34-23-12-7-20(8-13-23)25-16-11-22(31)19-26(25)32/h7-16,19,27H,2-6,17-18H2,1H3,(H,33,37)(H,34,38)(H,35,36)
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14n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144020
PNG
(3-{4-[1-(4-Benzofuran-2-yl-phenylcarbamoyl)-heptyl...)
Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C32H34N2O6/c1-2-3-4-5-10-28(39-26-17-13-23(14-18-26)31(37)33-20-19-30(35)36)32(38)34-25-15-11-22(12-16-25)29-21-24-8-6-7-9-27(24)40-29/h6-9,11-18,21,28H,2-5,10,19-20H2,1H3,(H,33,37)(H,34,38)(H,35,36)
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17n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144015
PNG
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-octyl]...)
Show SMILES CCCCCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C33H36N2O5/c1-2-3-4-5-9-27(21-23-11-13-25(14-12-23)32(38)34-20-19-31(36)37)33(39)35-28-17-15-24(16-18-28)30-22-26-8-6-7-10-29(26)40-30/h6-8,10-18,22,27H,2-5,9,19-21H2,1H3,(H,34,38)(H,35,39)(H,36,37)
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20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144008
PNG
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C37H36N2O5/c1-37(2,3)29-16-12-25(13-17-29)31(22-24-8-10-27(11-9-24)35(42)38-21-20-34(40)41)36(43)39-30-18-14-26(15-19-30)33-23-28-6-4-5-7-32(28)44-33/h4-19,23,31H,20-22H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)
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29n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144002
PNG
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(2',4'-dichloro-bi...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C35H34Cl2N2O4/c1-35(2,3)26-12-8-24(9-13-26)30(20-22-4-6-25(7-5-22)33(42)38-19-18-32(40)41)34(43)39-28-15-10-23(11-16-28)29-17-14-27(36)21-31(29)37/h4-17,21,30H,18-20H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)
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33n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144008
PNG
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C37H36N2O5/c1-37(2,3)29-16-12-25(13-17-29)31(22-24-8-10-27(11-9-24)35(42)38-21-20-34(40)41)36(43)39-30-18-14-26(15-19-30)33-23-28-6-4-5-7-32(28)44-33/h4-19,23,31H,20-22H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)
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69n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced monkey adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144003
PNG
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-trifluoromethox...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N2O5/c1-29(2,3)22-10-8-20(9-11-22)25(28(39)35-23-12-14-24(15-13-23)40-30(31,32)33)18-19-4-6-21(7-5-19)27(38)34-17-16-26(36)37/h4-15,25H,16-18H2,1-3H3,(H,34,38)(H,35,39)(H,36,37)
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110n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144016
PNG
(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C34H34N2O5/c1-34(2,3)27-15-9-25(10-16-27)31(41-29-19-13-26(14-20-29)32(39)35-22-21-30(37)38)33(40)36-28-17-11-24(12-18-28)23-7-5-4-6-8-23/h4-20,31H,21-22H2,1-3H3,(H,35,39)(H,36,40)(H,37,38)
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144n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144009
PNG
(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21-,23-
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254n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144004
PNG
(3-{4-[2-(Biphenyl-4-ylcarbamoyl)-2-(4-tert-butyl-p...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C35H36N2O4/c1-35(2,3)29-17-13-27(14-18-29)31(23-24-9-11-28(12-10-24)33(40)36-22-21-32(38)39)34(41)37-30-19-15-26(16-20-30)25-7-5-4-6-8-25/h4-20,31H,21-23H2,1-3H3,(H,36,40)(H,37,41)(H,38,39)
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300n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144012
PNG
(4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-phenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Oc1ccc(cc1)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N6O3/c1-32(2,3)25-15-9-23(10-16-25)28(30(40)33-26-17-11-22(12-18-26)21-7-5-4-6-8-21)41-27-19-13-24(14-20-27)29(39)34-31-35-37-38-36-31/h4-20,28H,1-3H3,(H,33,40)(H2,34,35,36,37,38,39)
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317n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144006
PNG
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(quinolin-3-ylcarb...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C32H33N3O4/c1-32(2,3)25-14-12-22(13-15-25)27(31(39)35-26-19-24-6-4-5-7-28(24)34-20-26)18-21-8-10-23(11-9-21)30(38)33-17-16-29(36)37/h4-15,19-20,27H,16-18H2,1-3H3,(H,33,38)(H,35,39)(H,36,37)
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610n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50144005
PNG
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-hydroxymethyl-p...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(CO)cc1
Show InChI InChI=1S/C30H34N2O5/c1-30(2,3)24-12-10-22(11-13-24)26(29(37)32-25-14-6-21(19-33)7-15-25)18-20-4-8-23(9-5-20)28(36)31-17-16-27(34)35/h4-15,26,33H,16-19H2,1-3H3,(H,31,36)(H,32,37)(H,34,35)
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1.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against glucagon induced human adenylate cyclase


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551432
PNG
(CHEMBL4758446)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1cccc(F)c1C2=O
Show InChI InChI=1S/C27H17ClFNO5/c1-13-9-11-14(12-10-13)22-20-21(26(34)30(25(20)33)18-8-3-2-6-16(18)28)27(35-22)23(31)15-5-4-7-17(29)19(15)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1
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n/an/an/an/a 345n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551438
PNG
(CHEMBL4750740)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C27H18ClNO5/c1-14-10-12-15(13-11-14)22-20-21(26(33)29(25(20)32)19-9-5-4-8-18(19)28)27(34-22)23(30)16-6-2-3-7-17(16)24(27)31/h2-13,20-22H,1H3/t20-,21-,22-/m1/s1
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n/an/an/an/a 170n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551441
PNG
(CHEMBL4745593)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)c(Cl)c1)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C28H20ClNO5/c1-14-7-10-16(11-8-14)23-21-22(27(34)30(26(21)33)17-12-9-15(2)20(29)13-17)28(35-23)24(31)18-5-3-4-6-19(18)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-/m1/s1
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n/an/an/an/a 750n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551431
PNG
(CHEMBL4762531)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1cccc(Cl)c1C2=O
Show InChI InChI=1S/C27H17Cl2NO5/c1-13-9-11-14(12-10-13)22-20-21(26(34)30(25(20)33)18-8-3-2-6-16(18)28)27(35-22)23(31)15-5-4-7-17(29)19(15)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1
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n/an/an/an/a 301n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551428
PNG
(CHEMBL4744718)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(F)cc1C2=O
Show InChI InChI=1S/C27H17ClFNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)28)27(35-22)23(31)16-11-10-15(29)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1
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n/an/an/an/a 692n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551427
PNG
(CHEMBL4777571)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(Cl)cc1C2=O
Show InChI InChI=1S/C27H17Cl2NO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)29)27(35-22)23(31)16-11-10-15(28)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1
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n/an/an/an/a 236n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551426
PNG
(CHEMBL4751732)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(Br)cc1C2=O
Show InChI InChI=1S/C27H17BrClNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)29)27(35-22)23(31)16-11-10-15(28)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1
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n/an/an/an/a 90n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551425
PNG
(CHEMBL4761309)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(C)cc1C2=O
Show InChI InChI=1S/C28H20ClNO5/c1-14-7-10-16(11-8-14)23-21-22(27(34)30(26(21)33)20-6-4-3-5-19(20)29)28(35-23)24(31)17-12-9-15(2)13-18(17)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-,28?/m1/s1
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n/an/an/an/a 300n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551415
PNG
(CHEMBL4744648)
Show SMILES Cc1cc(C)cc(c1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H20ClNO5/c1-14-11-15(2)13-18(12-14)30-26(33)21-22(27(30)34)28(35-23(21)16-7-9-17(29)10-8-16)24(31)19-5-3-4-6-20(19)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-/m1/s1
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n/an/an/an/a 310n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551414
PNG
(CHEMBL4779970)
Show SMILES Fc1ccc(cc1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H15ClFNO5/c27-14-7-5-13(6-8-14)21-19-20(25(33)29(24(19)32)16-11-9-15(28)10-12-16)26(34-21)22(30)17-3-1-2-4-18(17)23(26)31/h1-12,19-21H/t19-,20-,21-/m1/s1
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n/an/an/an/a 530n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551412
PNG
(CHEMBL4764988)
Show SMILES CCc1ccc(cc1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H20ClNO5/c1-2-15-7-13-18(14-8-15)30-26(33)21-22(27(30)34)28(35-23(21)16-9-11-17(29)12-10-16)24(31)19-5-3-4-6-20(19)25(28)32/h3-14,21-23H,2H2,1H3/t21-,22-,23-/m1/s1
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n/an/an/an/a 430n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551409
PNG
(CHEMBL4789237)
Show SMILES CCc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)cc1)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C29H23NO5/c1-3-17-10-12-18(13-11-17)24-22-23(28(34)30(27(22)33)19-14-8-16(2)9-15-19)29(35-24)25(31)20-6-4-5-7-21(20)26(29)32/h4-15,22-24H,3H2,1-2H3/t22-,23-,24-/m1/s1
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n/an/an/an/a 670n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551407
PNG
(CHEMBL4786932)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)cc1F)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C28H20FNO5/c1-14-7-10-16(11-8-14)23-21-22(27(34)30(26(21)33)20-12-9-15(2)13-19(20)29)28(35-23)24(31)17-5-3-4-6-18(17)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-/m1/s1
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n/an/an/an/a 770n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551406
PNG
(CHEMBL4740707)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)c(C)c1)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C29H23NO5/c1-15-8-11-18(12-9-15)24-22-23(28(34)30(27(22)33)19-13-10-16(2)17(3)14-19)29(35-24)25(31)20-6-4-5-7-21(20)26(29)32/h4-14,22-24H,1-3H3/t22-,23-,24-/m1/s1
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n/an/an/an/a 210n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551444
PNG
(CHEMBL4763908)
Show SMILES COc1cccc(c1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(C)cc1
Show InChI InChI=1S/C28H21NO6/c1-15-10-12-16(13-11-15)23-21-22(27(33)29(26(21)32)17-6-5-7-18(14-17)34-2)28(35-23)24(30)19-8-3-4-9-20(19)25(28)31/h3-14,21-23H,1-2H3/t21-,22-,23-/m1/s1
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n/an/an/an/a 960n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens (Human))
BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
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Article
PubMed
n/an/an/an/a 71n/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the adenylate cyclase stimulation


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
Adenylate cyclase type 2


(Homo sapiens (Human))
BDBM50551405
PNG
(CHEMBL4784488)
Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(F)c(Cl)c1)C(=O)c1ccccc1C2=O
Show InChI InChI=1S/C27H17ClFNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)15-10-11-19(29)18(28)12-15)27(35-22)23(31)16-4-2-3-5-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-/m1/s1
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n/an/an/an/a 520n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...


Eur J Med Chem 191: (2020)

More data for this
Ligand-Target Pair