Compile Data Set for Download or QSAR

Found 30 hits for UniProtKB: Q08462   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Adenylate cyclase (Homo sapiens (Human))	BDBM50144001 (3-{4-[1-(2',4'-Dichloro-biphenyl-4-ylcarbamoyl)-he...) Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C30H32Cl2N2O5/c1-2-3-4-5-6-27(39-24-14-9-21(10-15-24)29(37)33-18-17-28(35)36)30(38)34-23-12-7-20(8-13-23)25-16-11-22(31)19-26(25)32/h7-16,19,27H,2-6,17-18H2,1H3,(H,33,37)(H,34,38)(H,35,36)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144020 (3-{4-[1-(4-Benzofuran-2-yl-phenylcarbamoyl)-heptyl...) Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C32H34N2O6/c1-2-3-4-5-10-28(39-26-17-13-23(14-18-26)31(37)33-20-19-30(35)36)32(38)34-25-15-11-22(12-16-25)29-21-24-8-6-7-9-27(24)40-29/h6-9,11-18,21,28H,2-5,10,19-20H2,1H3,(H,33,37)(H,34,38)(H,35,36)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144015 (3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-octyl]...) Show SMILES CCCCCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C33H36N2O5/c1-2-3-4-5-9-27(21-23-11-13-25(14-12-23)32(38)34-20-19-31(36)37)33(39)35-28-17-15-24(16-18-28)30-22-26-8-6-7-10-29(26)40-30/h6-8,10-18,22,27H,2-5,9,19-21H2,1H3,(H,34,38)(H,35,39)(H,36,37)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144008 (3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C37H36N2O5/c1-37(2,3)29-16-12-25(13-17-29)31(22-24-8-10-27(11-9-24)35(42)38-21-20-34(40)41)36(43)39-30-18-14-26(15-19-30)33-23-28-6-4-5-7-32(28)44-33/h4-19,23,31H,20-22H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144002 (3-{4-[2-(4-tert-Butyl-phenyl)-2-(2',4'-dichloro-bi...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C35H34Cl2N2O4/c1-35(2,3)26-12-8-24(9-13-26)30(20-22-4-6-25(7-5-22)33(42)38-19-18-32(40)41)34(43)39-28-15-10-23(11-16-28)29-17-14-27(36)21-31(29)37/h4-17,21,30H,18-20H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144008 (3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C37H36N2O5/c1-37(2,3)29-16-12-25(13-17-29)31(22-24-8-10-27(11-9-24)35(42)38-21-20-34(40)41)36(43)39-30-18-14-26(15-19-30)33-23-28-6-4-5-7-32(28)44-33/h4-19,23,31H,20-22H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	69	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced monkey adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144003 (3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-trifluoromethox...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C30H31F3N2O5/c1-29(2,3)22-10-8-20(9-11-22)25(28(39)35-23-12-14-24(15-13-23)40-30(31,32)33)18-19-4-6-21(7-5-19)27(38)34-17-16-26(36)37/h4-15,25H,16-18H2,1-3H3,(H,34,38)(H,35,39)(H,36,37)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144016 (3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...) Show SMILES CC(C)(C)c1ccc(cc1)C(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C34H34N2O5/c1-34(2,3)27-15-9-25(10-16-27)31(41-29-19-13-26(14-20-29)32(39)35-22-21-30(37)38)33(40)36-28-17-11-24(12-18-28)23-7-5-4-6-8-23/h4-20,31H,21-22H2,1-3H3,(H,35,39)(H,36,40)(H,37,38)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	144	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144009 (3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...) Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21-,23-	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	254	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144004 (3-{4-[2-(Biphenyl-4-ylcarbamoyl)-2-(4-tert-butyl-p...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C35H36N2O4/c1-35(2,3)29-17-13-27(14-18-29)31(23-24-9-11-28(12-10-24)33(40)36-22-21-32(38)39)34(41)37-30-19-15-26(16-20-30)25-7-5-4-6-8-25/h4-20,31H,21-23H2,1-3H3,(H,36,40)(H,37,41)(H,38,39)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144012 (4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-phenyl)-...) Show SMILES CC(C)(C)c1ccc(cc1)C(Oc1ccc(cc1)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C32H30N6O3/c1-32(2,3)25-15-9-23(10-16-25)28(30(40)33-26-17-11-22(12-18-26)21-7-5-4-6-8-21)41-27-19-13-24(14-20-27)29(39)34-31-35-37-38-36-31/h4-20,28H,1-3H3,(H,33,40)(H2,34,35,36,37,38,39)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	317	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144006 (3-{4-[2-(4-tert-Butyl-phenyl)-2-(quinolin-3-ylcarb...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cnc2ccccc2c1 Show InChI InChI=1S/C32H33N3O4/c1-32(2,3)25-14-12-22(13-15-25)27(31(39)35-26-19-24-6-4-5-7-28(24)34-20-26)18-21-8-10-23(11-9-21)30(38)33-17-16-29(36)37/h4-15,19-20,27H,16-18H2,1-3H3,(H,33,38)(H,35,39)(H,36,37)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50144005 (3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-hydroxymethyl-p...) Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(CO)cc1 Show InChI InChI=1S/C30H34N2O5/c1-30(2,3)24-12-10-22(11-13-24)26(29(37)32-25-14-6-21(19-33)7-15-25)18-20-4-8-23(9-5-20)28(36)31-17-16-27(34)35/h4-15,26,33H,16-19H2,1-3H3,(H,31,36)(H,32,37)(H,34,35)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against glucagon induced human adenylate cyclase				Bioorg Med Chem Lett 14: 2047-50 (2004) Article DOI: 10.1016/j.bmcl.2004.02.056 BindingDB Entry DOI: 10.7270/Q2XS5TTH
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551432 (CHEMBL4758446) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1cccc(F)c1C2=O Show InChI InChI=1S/C27H17ClFNO5/c1-13-9-11-14(12-10-13)22-20-21(26(34)30(25(20)33)18-8-3-2-6-16(18)28)27(35-22)23(31)15-5-4-7-17(29)19(15)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	345	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551438 (CHEMBL4750740) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccccc1C2=O Show InChI InChI=1S/C27H18ClNO5/c1-14-10-12-15(13-11-14)22-20-21(26(33)29(25(20)32)19-9-5-4-8-18(19)28)27(34-22)23(30)16-6-2-3-7-17(16)24(27)31/h2-13,20-22H,1H3/t20-,21-,22-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551441 (CHEMBL4745593) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)c(Cl)c1)C(=O)c1ccccc1C2=O Show InChI InChI=1S/C28H20ClNO5/c1-14-7-10-16(11-8-14)23-21-22(27(34)30(26(21)33)17-12-9-15(2)20(29)13-17)28(35-23)24(31)18-5-3-4-6-19(18)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551431 (CHEMBL4762531) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1cccc(Cl)c1C2=O Show InChI InChI=1S/C27H17Cl2NO5/c1-13-9-11-14(12-10-13)22-20-21(26(34)30(25(20)33)18-8-3-2-6-16(18)28)27(35-22)23(31)15-5-4-7-17(29)19(15)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	301	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551428 (CHEMBL4744718) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(F)cc1C2=O Show InChI InChI=1S/C27H17ClFNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)28)27(35-22)23(31)16-11-10-15(29)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	692	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551427 (CHEMBL4777571) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(Cl)cc1C2=O Show InChI InChI=1S/C27H17Cl2NO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)29)27(35-22)23(31)16-11-10-15(28)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	236	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551426 (CHEMBL4751732) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(Br)cc1C2=O Show InChI InChI=1S/C27H17BrClNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)19-5-3-2-4-18(19)29)27(35-22)23(31)16-11-10-15(28)12-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-,27?/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551425 (CHEMBL4761309) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccccc1Cl)C(=O)c1ccc(C)cc1C2=O Show InChI InChI=1S/C28H20ClNO5/c1-14-7-10-16(11-8-14)23-21-22(27(34)30(26(21)33)20-6-4-3-5-19(20)29)28(35-23)24(31)17-12-9-15(2)13-18(17)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-,28?/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551415 (CHEMBL4744648) Show SMILES Cc1cc(C)cc(c1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H20ClNO5/c1-14-11-15(2)13-18(12-14)30-26(33)21-22(27(30)34)28(35-23(21)16-7-9-17(29)10-8-16)24(31)19-5-3-4-6-20(19)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551414 (CHEMBL4779970) Show SMILES Fc1ccc(cc1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H15ClFNO5/c27-14-7-5-13(6-8-14)21-19-20(25(33)29(24(19)32)16-11-9-15(28)10-12-16)26(34-21)22(30)17-3-1-2-4-18(17)23(26)31/h1-12,19-21H/t19-,20-,21-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551412 (CHEMBL4764988) Show SMILES CCc1ccc(cc1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H20ClNO5/c1-2-15-7-13-18(14-8-15)30-26(33)21-22(27(30)34)28(35-23(21)16-9-11-17(29)12-10-16)24(31)19-5-3-4-6-20(19)25(28)32/h3-14,21-23H,2H2,1H3/t21-,22-,23-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	430	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551409 (CHEMBL4789237) Show SMILES CCc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)cc1)C(=O)c1ccccc1C2=O Show InChI InChI=1S/C29H23NO5/c1-3-17-10-12-18(13-11-17)24-22-23(28(34)30(27(22)33)19-14-8-16(2)9-15-19)29(35-24)25(31)20-6-4-5-7-21(20)26(29)32/h4-15,22-24H,3H2,1-2H3/t22-,23-,24-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	670	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551407 (CHEMBL4786932) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)cc1F)C(=O)c1ccccc1C2=O Show InChI InChI=1S/C28H20FNO5/c1-14-7-10-16(11-8-14)23-21-22(27(34)30(26(21)33)20-12-9-15(2)13-19(20)29)28(35-23)24(31)17-5-3-4-6-18(17)25(28)32/h3-13,21-23H,1-2H3/t21-,22-,23-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	770	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551406 (CHEMBL4740707) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(C)c(C)c1)C(=O)c1ccccc1C2=O Show InChI InChI=1S/C29H23NO5/c1-15-8-11-18(12-9-15)24-22-23(28(34)30(27(22)33)19-13-10-16(2)17(3)14-19)29(35-24)25(31)20-6-4-5-7-21(20)26(29)32/h4-14,22-24H,1-3H3/t22-,23-,24-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551444 (CHEMBL4763908) Show SMILES COc1cccc(c1)N1C(=O)[C@H]2[C@H](OC3([C@H]2C1=O)C(=O)c1ccccc1C3=O)c1ccc(C)cc1 Show InChI InChI=1S/C28H21NO6/c1-15-10-12-16(13-11-15)23-21-22(27(33)29(26(21)32)17-6-5-7-18(14-17)34-2)28(35-23)24(30)19-8-3-4-9-20(19)25(28)31/h3-14,21-23H,1-2H3/t21-,22-,23-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	960	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens (Human))	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
University of Lund Curated by ChEMBL					Assay Description Compound was tested for the adenylate cyclase stimulation				J Med Chem 35: 502-7 (1992) Article DOI: 10.1021/jm00081a010 BindingDB Entry DOI: 10.7270/Q2TH8N95
					More data for this Ligand-Target Pair
Adenylate cyclase type 2 (Homo sapiens (Human))	BDBM50551405 (CHEMBL4784488) Show SMILES Cc1ccc(cc1)[C@H]1OC2([C@@H]3[C@H]1C(=O)N(C3=O)c1ccc(F)c(Cl)c1)C(=O)c1ccccc1C2=O Show InChI InChI=1S/C27H17ClFNO5/c1-13-6-8-14(9-7-13)22-20-21(26(34)30(25(20)33)15-10-11-19(29)18(28)12-15)27(35-22)23(31)16-4-2-3-5-17(16)24(27)32/h2-12,20-22H,1H3/t20-,21-,22-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	520	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level measured after 30 mins by LANCE Ultra cAMP Det...				Eur J Med Chem 191: (2020)
					More data for this Ligand-Target Pair