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Found 239 of ic50 for UniProtKB: P07237
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561112(CHEMBL4748449)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561113(CHEMBL4786482)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41977(6-[(4-chlorophenyl)-(4-morpholinyl)methyl]-1,3-ben...)
Affinity DataIC50:  92nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50500107(CHEMBL3741464)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523105(CHEMBL4483086)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523107(CHEMBL4472710)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41988(6-[(4-methoxyphenyl)-(4-morpholinyl)methyl]-1,3-be...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561135(CHEMBL4740031)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561142(CHEMBL1688556 | NSC-1010)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM156414(US9023354, AD4-1505)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM86370(Juniferdin derivative, 1)
Affinity DataIC50:  156nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523127(CHEMBL4459949)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM86381(Juniferdin derivative, 13)
Affinity DataIC50:  167nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561127(CHEMBL591855 | SJ000112346)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561114(CHEMBL4780610)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561125(CHEMBL590899 | SJ000128935)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561124(CHEMBL4790355)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41970(6-[1-pyrrolidinyl-(3,4,5-trimethoxyphenyl)methyl]-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561129(CHEMBL600752 | GNF-Pf-3313)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561161(CHEMBL4753606)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561132(CHEMBL1700391)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41972(6-[(4-fluorophenyl)-(1-pyrrolidinyl)methyl]-1,3-be...)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561111(CHEMBL4751839)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41987(6-[1,3-benzodioxol-5-yl(4-morpholinyl)methyl]-1,3-...)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561162(CHEMBL4776896)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561144(CHEMBL4782018)
Affinity DataIC50: <200nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523120(CHEMBL4550951)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523113(CHEMBL4446669)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523137(CHEMBL4472807)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41981(6-[(3-methoxy-4-oxidanyl-phenyl)-morpholin-4-yl-me...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561106(CHEMBL2323557 | NSC-368277)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM271332(US10064853, Compound 1)
Affinity DataIC50:  250nMAssay Description:Insulin reductase assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM271332(US10064853, Compound 1)
Affinity DataIC50:  250nMAssay Description:Insulin reductase assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561108(CHEMBL4799930)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561153(CHEMBL4782811)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561180(CHEMBL4763853)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41986(6-[(3,4-dimethoxyphenyl)-(4-morpholinyl)methyl]-1,...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50500101(CHEMBL1979298)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561163(CHEMBL4753733)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41964(6-[(2-methoxyphenyl)-(4-morpholinyl)methyl]-1,3-be...)
Affinity DataIC50:  330nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561179(CHEMBL4764068)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41965(6-[(2-hydroxyphenyl)-(4-morpholinyl)methyl]-1,3-be...)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM41984(6-[1,3-benzodioxol-5-yl(1-piperidinyl)methyl]-1,3-...)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561137(CHEMBL4755661)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561176(CHEMBL4776190)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50523112(CHEMBL4464788)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561110(CHEMBL4745645)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561131(CHEMBL1434798)
Affinity DataIC50:  370nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561146(CHEMBL4747596)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50561145(CHEMBL4756890)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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