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Compile Data Set for Download or QSAR

Found 180 hits of ic50 for UniProtKB: Q96SB4   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448544
PNG
(N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)19-3-4-22(33-13-11-32(12-14-33)17-20-2-1-15-35-20)21(16-19)31-25(34)24-6-5-23(36-24)18-7-9-30-10-8-18/h1-10,15-16H,11-14,17H2,(H,31,34)
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n/an/a 0.370n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448683
PNG
(N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-26-17)29-9-7-28(8-10-29)13-16-12-25-14-31-16/h1-6,11-12,14H,7-10,13H2,(H,27,30)
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n/an/a 0.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448727
PNG
(5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-5- y...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)15-19-14-29-16-36-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13-14,16-17H,5-12,15H2,(H,30,33)
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n/an/a 0.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448695
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C26H28F3N3O4/c27-26(28,29)20-1-2-22(32-10-8-31(9-11-32)16-18-5-12-35-17-18)21(15-20)30-25(33)24-4-3-23(36-24)19-6-13-34-14-7-19/h1-5,12,15,17,19H,6-11,13-14,16H2,(H,30,33)
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n/an/a 0.700n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448663
PNG
(N-(2-(4-(oxazol-5-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-35-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)
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n/an/a 0.760n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500359
PNG
(CHEMBL3747611 | US11066363, Compound 13)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn[nH]1
Show InChI InChI=1S/C23H19N5O/c1-4-13-8-16-17(9-15(13)19-11-25-28-27-19)23(2,3)22-20(21(16)29)14-6-5-12(10-24)7-18(14)26-22/h5-9,11,26H,4H2,1-3H3,(H,25,27,28)
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n/an/a 0.884n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500360
PNG
(CHEMBL3747134 | US11066363, Compound 9)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cc[nH]n1
Show InChI InChI=1S/C24H20N4O/c1-4-14-10-17-18(11-16(14)19-7-8-26-28-19)24(2,3)23-21(22(17)29)15-6-5-13(12-25)9-20(15)27-23/h5-11,27H,4H2,1-3H3,(H,26,28)
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n/an/a 1.15n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448673
PNG
(N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1-yl)...)
Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H23ClN4O3/c26-19-3-4-22(30-13-11-29(12-14-30)17-20-2-1-15-32-20)21(16-19)28-25(31)24-6-5-23(33-24)18-7-9-27-10-8-18/h1-10,15-16H,11-14,17H2,(H,28,31)
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n/an/a 1.20n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448662
PNG
(N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-35-16-30-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)
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n/an/a 1.30n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448675
PNG
(N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-20(19(14-16)27-21(30)18-5-1-2-8-26-18)29-11-9-28(10-12-29)15-17-4-3-13-31-17/h1-8,13-14H,9-12,15H2,(H,27,30)
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n/an/a 1.40n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448664
PNG
(5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-4- y...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)14-19-15-36-16-29-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13,15-17H,5-12,14H2,(H,30,33)
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n/an/a 1.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448726
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-13-11-32(12-14-33)16-19-7-10-30-36-19)20(15-18)31-24(34)23-4-3-22(35-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,31,34)
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n/an/a 1.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448697
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccoc2)CC1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O3/c1-15-2-5-20(31-15)21(29)26-18-12-17(22(23,24)25)3-4-19(18)28-9-7-27(8-10-28)13-16-6-11-30-14-16/h2-6,11-12,14H,7-10,13H2,1H3,(H,26,29)
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n/an/a 1.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101734
PNG
(US9695160, 31 | US9796707, Compound 31)
Show SMILES CSc1nccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)n1
Show InChI InChI=1S/C23H24F3N5O2S/c1-15-3-6-20(33-15)21(32)29-18-13-16(23(24,25)26)4-5-19(18)31-11-9-30(10-12-31)14-17-7-8-27-22(28-17)34-2/h3-8,13H,9-12,14H2,1-2H3,(H,29,32)
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n/an/a 1.90n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101734
PNG
(US9695160, 31 | US9796707, Compound 31)
Show SMILES CSc1nccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)n1
Show InChI InChI=1S/C23H24F3N5O2S/c1-15-3-6-20(33-15)21(32)29-18-13-16(23(24,25)26)4-5-19(18)31-11-9-30(10-12-31)14-17-7-8-27-22(28-17)34-2/h3-8,13H,9-12,14H2,1-2H3,(H,29,32)
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n/an/a 1.90n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500357
PNG
(CHEMBL3746522 | US11066363, Compound 31)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CCN(C)C)c1
Show InChI InChI=1S/C28H29N5O/c1-6-18-12-22-23(13-21(18)19-15-30-33(16-19)10-9-32(4)5)28(2,3)27-25(26(22)34)20-8-7-17(14-29)11-24(20)31-27/h7-8,11-13,15-16,31H,6,9-10H2,1-5H3
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n/an/a 1.91n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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PubMed
n/an/a 2.5n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human SRPK1 using GRSRSRSRSR as substrate by [gamma-33P]-ATP assay


Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM504520
PNG
(9-ethyl-6,6-dimethyl-11-oxo-8- (pyrimidin-5-yl)-6,...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cncnc1
Show InChI InChI=1S/C25H20N4O/c1-4-15-8-19-20(9-18(15)16-11-27-13-28-12-16)25(2,3)24-22(23(19)30)17-6-5-14(10-26)7-21(17)29-24/h5-9,11-13,29H,4H2,1-3H3
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n/an/a 2.53n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101825
PNG
(US9695160, 39 | US9796707, Compound 39)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)20-4-5-23(34-13-11-33(12-14-34)18-21-3-1-2-10-31-21)22(17-20)32-26(35)25-7-6-24(37-25)19-8-15-36-16-9-19/h1-7,10,17,19H,8-9,11-16,18H2,(H,32,35)
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n/an/a 2.60n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101825
PNG
(US9695160, 39 | US9796707, Compound 39)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)20-4-5-23(34-13-11-33(12-14-34)18-21-3-1-2-10-31-21)22(17-20)32-26(35)25-7-6-24(37-25)19-8-15-36-16-9-19/h1-7,10,17,19H,8-9,11-16,18H2,(H,32,35)
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n/an/a 2.60n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM504519
PNG
((9-ethyl-6,6-dimethyl-11-oxo-8- (pyridin-4-yl)-6,1...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1ccncc1
Show InChI InChI=1S/C26H21N3O/c1-4-16-12-20-21(13-19(16)17-7-9-28-10-8-17)26(2,3)25-23(24(20)30)18-6-5-15(14-27)11-22(18)29-25/h5-13,29H,4H2,1-3H3
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n/an/a 2.61n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500351
PNG
(CHEMBL3746960 | US11066363, Compound 19)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCN(C)CC1
Show InChI InChI=1S/C26H28N4O/c1-5-17-13-19-20(14-22(17)30-10-8-29(4)9-11-30)26(2,3)25-23(24(19)31)18-7-6-16(15-27)12-21(18)28-25/h6-7,12-14,28H,5,8-11H2,1-4H3
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n/an/a 2.66n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448715
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(13-15)27-20(30)17-3-1-2-7-25-17)29-11-9-28(10-12-29)14-16-6-8-26-31-16/h1-8,13H,9-12,14H2,(H,27,30)
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n/an/a 2.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500356
PNG
(CHEMBL3747406 | US11066363, Compound 7)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(C)c1
Show InChI InChI=1S/C25H22N4O/c1-5-15-9-19-20(10-18(15)16-12-27-29(4)13-16)25(2,3)24-22(23(19)30)17-7-6-14(11-26)8-21(17)28-24/h6-10,12-13,28H,5H2,1-4H3
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n/an/a 3.01n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
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n/an/a 3.18n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
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n/an/a 3.18n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448647
PNG
(N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H28F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)16-19-5-8-29-31-19)20(15-18)30-24(34)23-4-3-22(36-23)17-6-13-35-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,29,31)(H,30,34)
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n/an/a 3.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448696
PNG
(N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)C2CCOCC2)C(F)(F)F)o1
Show InChI InChI=1S/C27H30F3N3O4/c1-18-2-4-21(36-18)17-32-10-12-33(13-11-32)23-5-3-20(27(28,29)30)16-22(23)31-26(34)25-7-6-24(37-25)19-8-14-35-15-9-19/h2-7,16,19H,8-15,17H2,1H3,(H,31,34)
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n/an/a 3.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Beijing Normal University

Curated by ChEMBL


Assay Description
Inhibition of human SRPK1 using GRSRSRSRSR as substrate by [gamma-33P]-ATP assay


Bioorg Med Chem 26: 1740-1750 (2018)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101676
PNG
(US9695160, 20 | US9796707, Compound 20)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-17-7-10-22(32-17)23(31)28-20-15-19(24(25,26)27)8-9-21(20)30-13-11-29(12-14-30)16-18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3,(H,28,31)
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n/an/a 4.40n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101676
PNG
(US9695160, 20 | US9796707, Compound 20)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-17-7-10-22(32-17)23(31)28-20-15-19(24(25,26)27)8-9-21(20)30-13-11-29(12-14-30)16-18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3,(H,28,31)
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n/an/a 4.40n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448661
PNG
(N-(2-(4-(oxazol-2-ylmethyl)piperazin-1-yl)-5- (tri...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ncco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-20(33-12-10-32(11-13-33)16-23-30-9-14-35-23)19(15-18)31-24(34)22-4-3-21(36-22)17-5-7-29-8-6-17/h1-9,14-15H,10-13,16H2,(H,31,34)
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n/an/a 4.60n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101690
PNG
(US9695160, 21 | US9796707, Compound 21)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-8-9-24(35-15-13-34(14-16-35)19-20-5-2-1-3-6-20)23(17-22)33-27(36)26-11-10-25(37-26)21-7-4-12-32-18-21/h1-12,17-18H,13-16,19H2,(H,33,36)
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n/an/a 4.60n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101690
PNG
(US9695160, 21 | US9796707, Compound 21)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-8-9-24(35-15-13-34(14-16-35)19-20-5-2-1-3-6-20)23(17-22)33-27(36)26-11-10-25(37-26)21-7-4-12-32-18-21/h1-12,17-18H,13-16,19H2,(H,33,36)
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n/an/a 4.60n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500355
PNG
(CHEMBL3747108 | US11066363, Compound 36)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(c1)C(=O)N(C)C
Show InChI InChI=1S/C27H25N5O2/c1-6-16-10-20-21(11-19(16)17-13-29-32(14-17)26(34)31(4)5)27(2,3)25-23(24(20)33)18-8-7-15(12-28)9-22(18)30-25/h7-11,13-14,30H,6H2,1-5H3
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n/an/a 4.75n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101824
PNG
(US9695160, 38 | US9796707, Compound 38)
Show SMILES OCc1cccc(c1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O3/c30-29(31,32)22-7-8-25(36-14-12-35(13-15-36)18-23-6-1-2-11-33-23)24(17-22)34-28(38)27-10-9-26(39-27)21-5-3-4-20(16-21)19-37/h1-11,16-17,37H,12-15,18-19H2,(H,34,38)
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n/an/a 5n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101824
PNG
(US9695160, 38 | US9796707, Compound 38)
Show SMILES OCc1cccc(c1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O3/c30-29(31,32)22-7-8-25(36-14-12-35(13-15-36)18-23-6-1-2-11-33-23)24(17-22)34-28(38)27-10-9-26(39-27)21-5-3-4-20(16-21)19-37/h1-11,16-17,37H,12-15,18-19H2,(H,34,38)
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n/an/a 5n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM50500353
PNG
(CHEMBL3746395 | US11066363, Compound 10)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnoc1
Show InChI InChI=1S/C24H19N3O2/c1-4-14-8-18-19(9-17(14)15-11-26-29-12-15)24(2,3)23-21(22(18)28)16-6-5-13(10-25)7-20(16)27-23/h5-9,11-12,27H,4H2,1-3H3
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n/an/a 5.09n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448729
PNG
(N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)17-4-5-20(19(13-17)27-21(30)18-3-1-2-7-26-18)29-10-8-28(9-11-29)14-16-6-12-31-15-16/h1-7,12-13,15H,8-11,14H2,(H,27,30)
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n/an/a 5.30n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448717
PNG
(N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)18-1-2-21(32-11-9-31(10-12-32)16-19-5-8-29-36-19)20(15-18)30-24(33)23-4-3-22(35-23)17-6-13-34-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,30,33)
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n/an/a 5.5n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
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n/an/a 5.90n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
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n/an/a 6n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448682
PNG
(N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)
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n/an/a 6.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101654
PNG
(US9695160, 14 | US9796707, Compound 14)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccncc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-1-2-23(35-15-13-34(14-16-35)18-19-5-9-31-10-6-19)22(17-21)33-26(36)25-4-3-24(37-25)20-7-11-32-12-8-20/h1-12,17H,13-16,18H2,(H,33,36)
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n/an/a 7.18n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM101654
PNG
(US9695160, 14 | US9796707, Compound 14)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccncc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-1-2-23(35-15-13-34(14-16-35)18-19-5-9-31-10-6-19)22(17-21)33-26(36)25-4-3-24(37-25)20-7-11-32-12-8-20/h1-12,17H,13-16,18H2,(H,33,36)
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n/an/a 7.18n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448674
PNG
(N-(5-chloro-2-(4-(oxazol-4-ylmethyl)piperazin-1-yl...)
Show SMILES Clc1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C24H22ClN5O3/c25-18-1-2-21(30-11-9-29(10-12-30)14-19-15-32-16-27-19)20(13-18)28-24(31)23-4-3-22(33-23)17-5-7-26-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,28,31)
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n/an/a 8.20n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448723
PNG
(N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)16-4-5-19(18(11-16)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)13-15-12-26-31-14-15/h1-6,11-12,14H,7-10,13H2,(H,27,30)
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n/an/a 8.80n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448718
PNG
(US10696661, Compound 65)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)19-1-2-21(32-9-7-31(8-10-32)15-17-14-29-35-16-17)20(13-19)30-24(33)23-4-3-22(36-23)18-5-11-34-12-6-18/h1-4,13-14,16,18H,5-12,15H2,(H,30,33)
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n/an/a 9.70n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448698
PNG
(5-methyl-N-(2-(4-((5-methylfuran-2-yl)methyl)piper...)
Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)o1
Show InChI InChI=1S/C23H24F3N3O3/c1-15-3-6-18(31-15)14-28-9-11-29(12-10-28)20-7-5-17(23(24,25)26)13-19(20)27-22(30)21-8-4-16(2)32-21/h3-8,13H,9-12,14H2,1-2H3,(H,27,30)
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n/an/a 10.7n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
SRSF protein kinase 1


(Homo sapiens (Human))
BDBM448670
PNG
(N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)18-1-2-21(34-13-11-33(12-14-34)16-19-7-10-30-32-19)20(15-18)31-24(35)23-4-3-22(36-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,30,32)(H,31,35)
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n/an/a 10.9n/an/an/an/an/an/a



Exonate Limited

US Patent


Assay Description
Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...


US Patent US10696661 (2020)

More data for this
Ligand-Target Pair
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