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Compile Data Set for Download or QSAR

Found 13 hits of kd for UniProtKB: P04150   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/an/a 2n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to GR (unknown origin)


Bioorg Med Chem 27: 2508-2520 (2019)


Article DOI: 10.1016/j.bmc.2019.03.022
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50381733
PNG
(CHEMBL2022651)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=Cc5c(C[C@]34C)cnn5-c3ccccc3)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C28H34N2O4/c1-26-13-17-15-29-30(19-6-4-3-5-7-19)22(17)12-18(26)8-9-20-21-10-11-28(34,24(33)16-31)27(21,2)14-23(32)25(20)26/h3-7,12,15,20-21,23,25,31-32,34H,8-11,13-14,16H2,1-2H3/t20-,21-,23-,25+,26-,27-,28-/m0/s1
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n/an/an/a 2.20n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50550121
PNG
(CHEMBL4787613)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=Cc5nn(cc5C[C@]34C)-c3ccccc3)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C28H34N2O4/c1-26-13-17-15-30(19-6-4-3-5-7-19)29-22(17)12-18(26)8-9-20-21-10-11-28(34,24(33)16-31)27(21,2)14-23(32)25(20)26/h3-7,12,15,20-21,23,25,31-32,34H,8-11,13-14,16H2,1-2H3/t20-,21-,23-,25+,26-,27-,28-/m0/s1
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n/an/an/a 2.20n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50381724
PNG
(CHEMBL2022858)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=Cc5c(C[C@]34C)cnn5-c3ccc(F)cc3)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C28H33FN2O4/c1-26-12-16-14-30-31(19-6-4-18(29)5-7-19)22(16)11-17(26)3-8-20-21-9-10-28(35,24(34)15-32)27(21,2)13-23(33)25(20)26/h4-7,11,14,20-21,23,25,32-33,35H,3,8-10,12-13,15H2,1-2H3/t20-,21-,23-,25+,26-,27-,28-/m0/s1
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n/an/an/a 2.60n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/an/a 2.80n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50550125
PNG
(CHEMBL4759037)
Show SMILES CCCCCCn1ncc2C[C@]3(C)[C@H]4[C@@H](O)C[C@@]5(C)[C@@H](CC[C@]5(O)C(=O)CO)[C@@H]4CCC3=Cc12
Show InChI InChI=1S/C28H42N2O4/c1-4-5-6-7-12-30-22-13-19-8-9-20-21-10-11-28(34,24(33)17-31)27(21,3)15-23(32)25(20)26(19,2)14-18(22)16-29-30/h13,16,20-21,23,25,31-32,34H,4-12,14-15,17H2,1-3H3/t20-,21-,23-,25+,26-,27-,28-/m0/s1
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n/an/an/a 9n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/an/a 15n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to GR (unknown origin)


Bioorg Med Chem 27: 2508-2520 (2019)


Article DOI: 10.1016/j.bmc.2019.03.022
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/an/a 19n/an/an/an/an/a



Boston University

Curated by ChEMBL


Assay Description
Inhibition of glucocorticoid receptor (unknown origin)


J Med Chem 62: 10005-10025 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01732
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/an/a 19n/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Binding affinity to glucocorticoid receptor


J Med Chem 53: 3349-60 (2010)


Article DOI: 10.1021/jm100052k
BindingDB Entry DOI: 10.7270/Q2BP03RQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50550126
PNG
(3en3hg4wsw | CHEBI:8382 | Cortan | Cortancyl | Dec...)
Show SMILES C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
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n/an/an/a 29n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50550124
PNG
(CHEMBL4764990)
Show SMILES COc1cccc(c1)-n1ncc2C[C@]3(C)[C@H]4[C@@H](O)C[C@@]5(C)[C@@H](CC[C@]5(O)C(=O)CO)[C@@H]4CCC3=Cc12
Show InChI InChI=1S/C29H36N2O5/c1-27-13-17-15-30-31(19-5-4-6-20(12-19)36-3)23(17)11-18(27)7-8-21-22-9-10-29(35,25(34)16-32)28(22,2)14-24(33)26(21)27/h4-6,11-12,15,21-22,24,26,32-33,35H,7-10,13-14,16H2,1-3H3/t21-,22-,24-,26+,27-,28-,29-/m0/s1
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n/an/an/a 32n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50550122
PNG
(CHEMBL4754182)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=Cc5nn(cc5C[C@]34C)-c3ccc(F)cc3)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C28H33FN2O4/c1-26-12-16-14-31(19-6-4-18(29)5-7-19)30-22(16)11-17(26)3-8-20-21-9-10-28(35,24(34)15-32)27(21,2)13-23(33)25(20)26/h4-7,11,14,20-21,23,25,32-33,35H,3,8-10,12-13,15H2,1-2H3/t20-,21-,23-,25+,26-,27-,28-/m0/s1
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n/an/an/a 138n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50550123
PNG
(CHEMBL4755113)
Show SMILES Cc1ccc(cc1)-n1cc2C[C@]3(C)[C@H]4[C@@H](O)C[C@@]5(C)[C@@H](CC[C@]5(O)C(=O)CO)[C@@H]4CCC3=Cc2n1
Show InChI InChI=1S/C29H36N2O4/c1-17-4-7-20(8-5-17)31-15-18-13-27(2)19(12-23(18)30-31)6-9-21-22-10-11-29(35,25(34)16-32)28(22,3)14-24(33)26(21)27/h4-5,7-8,12,15,21-22,24,26,32-33,35H,6,9-11,13-14,16H2,1-3H3/t21-,22-,24-,26+,27-,28-,29-/m0/s1
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n/an/an/a 883n/an/an/an/an/a



University of Iowa

Curated by ChEMBL


Assay Description
Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and G...


RSC Med Chem 12: 203-212 (2021)

More data for this
Ligand-Target Pair