BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2866 hits of ic50 for UniProtKB: P34913   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50264106
PNG
(CHEMBL3818875)
Show SMILES CNc1nc(C)nc(N[C@H]2CCC[C@H](C2)C(=O)NCc2ccc(cc2C(F)(F)F)C#N)n1
Show InChI InChI=1S/C21H24F3N7O/c1-12-28-19(26-2)31-20(29-12)30-16-5-3-4-14(9-16)18(32)27-11-15-7-6-13(10-25)8-17(15)21(22,23)24/h6-8,14,16H,3-5,9,11H2,1-2H3,(H,27,32)(H2,26,28,29,30,31)/t14-,16+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0270n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay


J Med Chem 61: 3541-3550 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01804
BindingDB Entry DOI: 10.7270/Q2ZP48KN
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50264106
PNG
(CHEMBL3818875)
Show SMILES CNc1nc(C)nc(N[C@H]2CCC[C@H](C2)C(=O)NCc2ccc(cc2C(F)(F)F)C#N)n1
Show InChI InChI=1S/C21H24F3N7O/c1-12-28-19(26-2)31-20(29-12)30-16-5-3-4-14(9-16)18(32)27-11-15-7-6-13(10-25)8-17(15)21(22,23)24/h6-8,14,16H,3-5,9,11H2,1-2H3,(H,27,32)(H2,26,28,29,30,31)/t14-,16+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0280n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid as substrate assessed as formation of 14,15-dihydroxy-5Z,8Z,11Zei...


J Med Chem 59: 6629-44 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01874
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50264106
PNG
(CHEMBL3818875)
Show SMILES CNc1nc(C)nc(N[C@H]2CCC[C@H](C2)C(=O)NCc2ccc(cc2C(F)(F)F)C#N)n1
Show InChI InChI=1S/C21H24F3N7O/c1-12-28-19(26-2)31-20(29-12)30-16-5-3-4-14(9-16)18(32)27-11-15-7-6-13(10-25)8-17(15)21(22,23)24/h6-8,14,16H,3-5,9,11H2,1-2H3,(H,27,32)(H2,26,28,29,30,31)/t14-,16+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0280n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid as substrate assessed as formation of 14,15-dihydroxy-5Z,8Z,11Zei...


J Med Chem 59: 6629-44 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01874
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50556773
PNG
(CHEMBL4745610)
Show SMILES Clc1ccc(NC(=O)N(CCN2CCOCC2)c2ccc3nc(NC(=O)Cc4ccccc4)sc3c2)cc1
Show InChI InChI=1S/C28H28ClN5O3S/c29-21-6-8-22(9-7-21)30-28(36)34(13-12-33-14-16-37-17-15-33)23-10-11-24-25(19-23)38-27(31-24)32-26(35)18-20-4-2-1-3-5-20/h1-11,19H,12-18H2,(H,30,36)(H,31,32,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.0820n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human sEH using PHOME as substrate measured after 15 mins by fluorescence assay


Eur J Med Chem 212: (2021)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50302462
PNG
(CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)
Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F
Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay


Bioorg Med Chem Lett 19: 5864-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50556760
PNG
(CHEMBL4781218)
Show SMILES Clc1ccc(NC(=O)Nc2nc3ccc(cc3s2)N(CCN2CCOCC2)C(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C27H26Cl2N6O3S/c28-18-1-5-20(6-2-18)30-25(36)33-26-32-23-10-9-22(17-24(23)39-26)35(12-11-34-13-15-38-16-14-34)27(37)31-21-7-3-19(29)4-8-21/h1-10,17H,11-16H2,(H,31,37)(H2,30,32,33,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human sEH using PHOME as substrate measured after 15 mins by fluorescence assay


Eur J Med Chem 212: (2021)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM342631
PNG
(5-[4-((R)-2-Hydroxy-propionyl)-piperazin-1-ylmethy...)
Show SMILES C[C@@H](O)C(=O)N1CCN(Cc2ccc(s2)C(=O)N(Cc2ccccc2)OC(F)(F)F)CC1
Show InChI InChI=1S/C21H24F3N3O4S/c1-15(28)19(29)26-11-9-25(10-12-26)14-17-7-8-18(32-17)20(30)27(31-21(22,23)24)13-16-5-3-2-4-6-16/h2-8,15,28H,9-14H2,1H3/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.122n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Compounds were tested in a biochemical screening assay using recombinant sEH purified from Sf9 insect cells and an artificial substrate, (3-phenyl-ox...


US Patent US9776991 (2017)


BindingDB Entry DOI: 10.7270/Q2V126ZH
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50445769
PNG
(CHEMBL3104615)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC2(CCCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C24H24F5N3O3/c25-18-3-1-4-19(26)20(18)21(33)31-13-10-23(11-14-31)9-2-12-32(15-23)22(34)30-16-5-7-17(8-6-16)35-24(27,28)29/h1,3-8H,2,9-15H2,(H,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.125n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenylox...


Bioorg Med Chem Lett 24: 565-70 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.020
BindingDB Entry DOI: 10.7270/Q2V69M26
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM342634
PNG
(5-[4-(Pyridine-3-carbonyl)-piperazin-1-ylmethyl]-t...)
Show SMILES FC(F)(F)c1ccccc1CNC(=O)c1ccc(CN2CCN(CC2)C(=O)c2cccnc2)s1
Show InChI InChI=1S/C24H23F3N4O2S/c25-24(26,27)20-6-2-1-4-17(20)15-29-22(32)21-8-7-19(34-21)16-30-10-12-31(13-11-30)23(33)18-5-3-9-28-14-18/h1-9,14H,10-13,15-16H2,(H,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.168n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Compounds were tested in a biochemical screening assay using recombinant sEH purified from Sf9 insect cells and an artificial substrate, (3-phenyl-ox...


US Patent US9776991 (2017)


BindingDB Entry DOI: 10.7270/Q2V126ZH
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441467
PNG
(CHEMBL2436573)
Show SMILES Oc1ccc(F)c(c1)C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C23H23F4N3O4/c24-19-6-3-16(31)13-18(19)20(32)29-10-7-22(8-11-29)9-12-30(14-22)21(33)28-15-1-4-17(5-2-15)34-23(25,26)27/h1-6,13,31H,7-12,14H2,(H,28,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441481
PNG
(CHEMBL2436579)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)c2cnoc2C2CC2)cc1
Show InChI InChI=1S/C23H25F3N4O4/c24-23(25,26)33-17-5-3-16(4-6-17)28-21(32)30-12-9-22(14-30)7-10-29(11-8-22)20(31)18-13-27-34-19(18)15-1-2-15/h3-6,13,15H,1-2,7-12,14H2,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441476
PNG
(CHEMBL2436575)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)c2cccc3ncccc23)cc1
Show InChI InChI=1S/C26H25F3N4O3/c27-26(28,29)36-19-8-6-18(7-9-19)31-24(35)33-16-12-25(17-33)10-14-32(15-11-25)23(34)21-3-1-5-22-20(21)4-2-13-30-22/h1-9,13H,10-12,14-17H2,(H,31,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50556771
PNG
(CHEMBL4759847)
Show SMILES Nc1nc2ccc(cc2s1)N(CCN1CCOCC1)C(=O)Nc1ccc(F)c(Br)c1
Show InChI InChI=1S/C20H21BrFN5O2S/c21-15-11-13(1-3-16(15)22)24-20(28)27(6-5-26-7-9-29-10-8-26)14-2-4-17-18(12-14)30-19(23)25-17/h1-4,11-12H,5-10H2,(H2,23,25)(H,24,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.25n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human sEH using PHOME as substrate measured after 15 mins by fluorescence assay


Eur J Med Chem 212: (2021)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441474
PNG
(CHEMBL2436563)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C23H22F5N3O2/c24-17-2-1-3-18(25)19(17)20(32)30-11-8-22(9-12-30)10-13-31(14-22)21(33)29-16-6-4-15(5-7-16)23(26,27)28/h1-7H,8-14H2,(H,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441483
PNG
(CHEMBL2436591)
Show SMILES CCC(CC)C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C22H30F3N3O3/c1-3-16(4-2)19(29)27-12-9-21(10-13-27)11-14-28(15-21)20(30)26-17-5-7-18(8-6-17)31-22(23,24)25/h5-8,16H,3-4,9-15H2,1-2H3,(H,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441469
PNG
(CHEMBL2436586)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)C2(CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F6N3O3/c22-20(23,24)19(5-6-19)16(31)29-10-7-18(8-11-29)9-12-30(13-18)17(32)28-14-1-3-15(4-2-14)33-21(25,26)27/h1-4H,5-13H2,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441470
PNG
(CHEMBL2436574)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C23H23ClF3N3O3/c24-19-4-2-1-3-18(19)20(31)29-12-9-22(10-13-29)11-14-30(15-22)21(32)28-16-5-7-17(8-6-16)33-23(25,26)27/h1-8H,9-15H2,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50264113
PNG
(CHEMBL4099452)
Show SMILES COc1ccc(CNC(=O)c2cccc(OC3CCCC3)c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H22F3NO3/c1-27-17-10-9-15(19(12-17)21(22,23)24)13-25-20(26)14-5-4-8-18(11-14)28-16-6-2-3-7-16/h4-5,8-12,16H,2-3,6-7,13H2,1H3,(H,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay


J Med Chem 61: 3541-3550 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01804
BindingDB Entry DOI: 10.7270/Q2ZP48KN
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50327850
PNG
(1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)p...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H22F3N3O4S/c1-14-2-8-18(9-3-14)31(28,29)26-12-10-16(11-13-26)25-19(27)24-15-4-6-17(7-5-15)30-20(21,22)23/h2-9,16H,10-13H2,1H3,(H2,24,25,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay


J Med Chem 53: 7067-75 (2010)


Article DOI: 10.1021/jm100691c
BindingDB Entry DOI: 10.7270/Q2GH9J6V
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM158481
PNG
(US9029401, 1728 (t-TUCB))
Show SMILES OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C21H21F3N2O5/c22-21(23,24)31-18-11-5-15(6-12-18)26-20(29)25-14-3-9-17(10-4-14)30-16-7-1-13(2-8-16)19(27)28/h1-2,5-8,11-12,14,17H,3-4,9-10H2,(H,27,28)(H2,25,26,29)/t14-,17-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of soluble epoxide hydrolase (unknown origin)


Bioorg Med Chem Lett 28: 762-768 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.003
BindingDB Entry DOI: 10.7270/Q2PV6NZ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50327846
PNG
(1-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(t...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C17H20F3N3O3/c18-17(19,20)26-14-5-3-12(4-6-14)21-16(25)22-13-7-9-23(10-8-13)15(24)11-1-2-11/h3-6,11,13H,1-2,7-10H2,(H2,21,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of soluble epoxide hydrolase (unknown origin)


Medchemcomm 379-384 (2012)


Article DOI: 10.1039/c2md00288d
BindingDB Entry DOI: 10.7270/Q2JD50RG
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50496759
PNG
(CHEMBL3222130)
Show SMILES CC(C)(C)OC(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1
Show InChI InChI=1S/C31H47N3O4/c1-30(2,3)38-29(36)34-12-10-33(11-13-34)9-4-5-14-37-27-8-6-7-26(18-27)32-28(35)22-31-19-23-15-24(20-31)17-25(16-23)21-31/h6-8,18,23-25H,4-5,9-17,19-22H2,1-3H3,(H,32,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...


Medchemcomm 379-384 (2012)


Article DOI: 10.1039/c2md00288d
BindingDB Entry DOI: 10.7270/Q2JD50RG
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351247
PNG
(CHEMBL1818385)
Show SMILES Fc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c(F)c1F
Show InChI InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-16(23)22-17-6-9-3-10(7-17)5-11(4-9)8-17/h1-2,9-11H,3-8H2,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of recombinant human liver soluble epoxide hydrolase expressed in baculovirus infected Sf21 cells using NEPC as substrate by fluorescence ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115078
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351248
PNG
(CHEMBL1818384)
Show SMILES Fc1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)c(F)c1F
Show InChI InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-17(23)22-16-10-4-8-3-9(6-10)7-11(16)5-8/h1-2,8-11,16H,3-7H2,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of recombinant human liver soluble epoxide hydrolase expressed in baculovirus infected Sf21 cells using NEPC as substrate by fluorescence ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115078
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50525808
PNG
(CHEMBL4454212)
Show SMILES CC12CC3CC1(C)CC3(CNC(=O)Nc1ccc(F)c(F)c1F)C2
Show InChI InChI=1S/C18H21F3N2O/c1-16-5-10-6-17(16,2)8-18(10,7-16)9-22-15(24)23-12-4-3-11(19)13(20)14(12)21/h3-4,10H,5-9H2,1-2H3,(H2,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of recombinant human liver soluble epoxide hydrolase expressed in baculovirus infected Sf21 cells using NEPC as substrate by fluorescence ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115078
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50539356
PNG
(CHEMBL4641404)
Show SMILES OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)N2C(=O)N(C(=O)C2=O)C23CC4CC(CC(Cl)(C4)C2)C3)cc1
Show InChI InChI=1S/C26H29ClN2O6/c27-25-10-15-9-16(11-25)13-26(12-15,14-25)29-22(31)21(30)28(24(29)34)18-3-7-20(8-4-18)35-19-5-1-17(2-6-19)23(32)33/h1-2,5-6,15-16,18,20H,3-4,7-14H2,(H,32,33)/t15?,16?,18-,20-,25?,26?
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase by kinetic fluorescent assay


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50539380
PNG
(CHEMBL4643551)
Show SMILES OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)NC23CC4CC(CC(Cl)(C4)C2)C3)cc1
Show InChI InChI=1S/C24H31ClN2O4/c25-23-10-15-9-16(11-23)13-24(12-15,14-23)27-22(30)26-18-3-7-20(8-4-18)31-19-5-1-17(2-6-19)21(28)29/h1-2,5-6,15-16,18,20H,3-4,7-14H2,(H,28,29)(H2,26,27,30)/t15?,16?,18-,20-,23?,24?
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase using cyano(2methoxy naphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl)methylcarbonate as substrate pre...


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50546449
PNG
(CHEMBL4746902)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CC3CCC2C3)cc1
Show InChI InChI=1S/C15H17F3N2O2/c16-15(17,18)22-12-5-3-11(4-6-12)19-14(21)20-13-8-9-1-2-10(13)7-9/h3-6,9-10,13H,1-2,7-8H2,(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase by kinetic fluorescent assay


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50546457
PNG
(CHEMBL4786305)
Show SMILES O=C(NCCCCCCCCCCNC(=O)NC1CC2CC1C=C2)NC1CC2CC1C=C2
Show InChI InChI=1S/C26H42N4O2/c31-25(29-23-17-19-9-11-21(23)15-19)27-13-7-5-3-1-2-4-6-8-14-28-26(32)30-24-18-20-10-12-22(24)16-20/h9-12,19-24H,1-8,13-18H2,(H2,27,29,31)(H2,28,30,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase by kinetic fluorescent assay


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50546459
PNG
(CHEMBL4759033)
Show SMILES O=C(NCCCCCCCCNC(=O)NC1CC2CCC1C2)NC1CC2CCC1C2
Show InChI InChI=1S/C24H42N4O2/c29-23(27-21-15-17-7-9-19(21)13-17)25-11-5-3-1-2-4-6-12-26-24(30)28-22-16-18-8-10-20(22)14-18/h17-22H,1-16H2,(H2,25,27,29)(H2,26,28,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase by kinetic fluorescent assay


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50546461
PNG
(CHEMBL4750771)
Show SMILES CC1(C)C2CCC1(C)C(C2)NC(=O)NCCCCCCCCNC(=O)NC1CC2CCC1(C)C2(C)C
Show InChI InChI=1S/C30H54N4O2/c1-27(2)21-13-15-29(27,5)23(19-21)33-25(35)31-17-11-9-7-8-10-12-18-32-26(36)34-24-20-22-14-16-30(24,6)28(22,3)4/h21-24H,7-20H2,1-6H3,(H2,31,33,35)(H2,32,34,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase by kinetic fluorescent assay


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50424629
PNG
(CHEMBL2313193)
Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)N1CCC(CC1)C(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C20H24N2O4S/c1-14-3-8-19(15(2)13-14)27(25,26)22-11-9-16(10-12-22)20(24)21-17-4-6-18(23)7-5-17/h3-8,13,16,23H,9-12H2,1-2H3,(H,21,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)me...


Bioorg Med Chem Lett 23: 417-21 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.084
BindingDB Entry DOI: 10.7270/Q2Z60QBJ
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351248
PNG
(CHEMBL1818384)
Show SMILES Fc1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)c(F)c1F
Show InChI InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-17(23)22-16-10-4-8-3-9(6-10)7-11(16)5-8/h1-2,8-11,16H,3-7H2,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Colorado State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins...


Bioorg Med Chem 20: 3255-62 (2012)


Article DOI: 10.1016/j.bmc.2012.03.058
BindingDB Entry DOI: 10.7270/Q28W3FB2
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50194500
PNG
(1-adamantan-1-yl-3-[4-(4-fluoro-phenoxy)-cyclohexy...)
Show SMILES Fc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1
Show InChI InChI=1S/C23H31FN2O2/c24-18-1-5-20(6-2-18)28-21-7-3-19(4-8-21)25-22(27)26-23-12-15-9-16(13-23)11-17(10-15)14-23/h1-2,5-6,15-17,19,21H,3-4,7-14H2,(H2,25,26,27)/t15?,16?,17?,19-,21+,23?
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Colorado State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins...


Bioorg Med Chem 20: 3255-62 (2012)


Article DOI: 10.1016/j.bmc.2012.03.058
BindingDB Entry DOI: 10.7270/Q28W3FB2
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50264152
PNG
(CHEMBL4072536)
Show SMILES COc1ccc(CNC(=O)c2ccc(F)c(OC3CCCC3)c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H21F4NO3/c1-28-16-8-6-14(17(11-16)21(23,24)25)12-26-20(27)13-7-9-18(22)19(10-13)29-15-4-2-3-5-15/h6-11,15H,2-5,12H2,1H3,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay


J Med Chem 61: 3541-3550 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01804
BindingDB Entry DOI: 10.7270/Q2ZP48KN
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351222
PNG
(CHEMBL1818408)
Show SMILES Fc1c(NC(=O)NC2CCCCCCC2)cccc1C(F)(F)F
Show InChI InChI=1S/C16H20F4N2O/c17-14-12(16(18,19)20)9-6-10-13(14)22-15(23)21-11-7-4-2-1-3-5-8-11/h6,9-11H,1-5,7-8H2,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351223
PNG
(CHEMBL1818407)
Show SMILES CCCCCCCNC(=O)Nc1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C15H20F4N2O/c1-2-3-4-5-6-10-20-14(22)21-12-9-7-8-11(13(12)16)15(17,18)19/h7-9H,2-6,10H2,1H3,(H2,20,21,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351226
PNG
(CHEMBL1818404)
Show SMILES Cc1ccc(NC(=O)NC2CCCCCCC2)cc1Cl
Show InChI InChI=1S/C16H23ClN2O/c1-12-9-10-14(11-15(12)17)19-16(20)18-13-7-5-3-2-4-6-8-13/h9-11,13H,2-8H2,1H3,(H2,18,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351228
PNG
(CHEMBL1817677)
Show SMILES Cc1ccc(NC(=O)NCC23CC4CC(CC(C4)C2)C3)cc1Cl
Show InChI InChI=1S/C19H25ClN2O/c1-12-2-3-16(7-17(12)20)22-18(23)21-11-19-8-13-4-14(9-19)6-15(5-13)10-19/h2-3,7,13-15H,4-6,8-11H2,1H3,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM53878
PNG
(4,5-dimethoxy-2-[2-(5-phenylthieno[2,3-d]pyrimidin...)
Show SMILES COc1cc(NC(=O)CSc2ncnc3scc(-c4ccccc4)c23)c(cc1OC)C(O)=O
Show InChI InChI=1S/C23H19N3O5S2/c1-30-17-8-14(23(28)29)16(9-18(17)31-2)26-19(27)11-33-22-20-15(13-6-4-3-5-7-13)10-32-21(20)24-12-25-22/h3-10,12H,11H2,1-2H3,(H,26,27)(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351242
PNG
(CHEMBL1818390)
Show SMILES Fc1ccc(NC(=O)NC2CCCCCCC2)c(F)c1F
Show InChI InChI=1S/C15H19F3N2O/c16-11-8-9-12(14(18)13(11)17)20-15(21)19-10-6-4-2-1-3-5-7-10/h8-10H,1-7H2,(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351243
PNG
(CHEMBL1818389)
Show SMILES CC1(C)C2CC1C(CNC(=O)Nc1ccc(F)c(F)c1F)CC2
Show InChI InChI=1S/C17H21F3N2O/c1-17(2)10-4-3-9(11(17)7-10)8-21-16(23)22-13-6-5-12(18)14(19)15(13)20/h5-6,9-11H,3-4,7-8H2,1-2H3,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351244
PNG
(CHEMBL1818388)
Show SMILES CC1C2CC(CC1NC(=O)Nc1ccc(F)c(F)c1F)C2(C)C
Show InChI InChI=1S/C17H21F3N2O/c1-8-10-6-9(17(10,2)3)7-13(8)22-16(23)21-12-5-4-11(18)14(19)15(12)20/h4-5,8-10,13H,6-7H2,1-3H3,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351245
PNG
(CHEMBL1818387)
Show SMILES CCCCCCCNC(=O)Nc1ccc(F)c(F)c1F
Show InChI InChI=1S/C14H19F3N2O/c1-2-3-4-5-6-9-18-14(20)19-11-8-7-10(15)12(16)13(11)17/h7-8H,2-6,9H2,1H3,(H2,18,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351246
PNG
(CHEMBL1818386)
Show SMILES Fc1ccc(NC(=O)NCC23CC4CC(CC(C4)C2)C3)c(F)c1F
Show InChI InChI=1S/C18H21F3N2O/c19-13-1-2-14(16(21)15(13)20)23-17(24)22-9-18-6-10-3-11(7-18)5-12(4-10)8-18/h1-2,10-12H,3-9H2,(H2,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351247
PNG
(CHEMBL1818385)
Show SMILES Fc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c(F)c1F
Show InChI InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-16(23)22-17-6-9-3-10(7-17)5-11(4-9)8-17/h1-2,9-11H,3-8H2,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50351248
PNG
(CHEMBL1818384)
Show SMILES Fc1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)c(F)c1F
Show InChI InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-17(23)22-16-10-4-8-3-9(6-10)7-11(16)5-8/h1-2,8-11,16H,3-7H2,(H2,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay


Bioorg Med Chem 19: 5585-95 (2011)


Article DOI: 10.1016/j.bmc.2011.07.034
BindingDB Entry DOI: 10.7270/Q2V69JZ1
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50445752
PNG
(CHEMBL3104441)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCOC3(CCN(CC3)C(=O)C3(CC3)c3ccccc3)C2)cc1
Show InChI InChI=1S/C26H28F3N3O4/c27-26(28,29)36-21-8-6-20(7-9-21)30-23(34)32-16-17-35-24(18-32)12-14-31(15-13-24)22(33)25(10-11-25)19-4-2-1-3-5-19/h1-9H,10-18H2,(H,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenylox...


Bioorg Med Chem Lett 24: 565-70 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.020
BindingDB Entry DOI: 10.7270/Q2V69M26
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441468
PNG
(CHEMBL2436564)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C23H22F5N3O3/c24-17-2-1-3-18(25)19(17)20(32)30-11-8-22(9-12-30)10-13-31(14-22)21(33)29-15-4-6-16(7-5-15)34-23(26,27)28/h1-7H,8-14H2,(H,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50441482
PNG
(CHEMBL2436577)
Show SMILES Cc1cnc(cn1)C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C22H24F3N5O3/c1-15-12-27-18(13-26-15)19(31)29-9-6-21(7-10-29)8-11-30(14-21)20(32)28-16-2-4-17(5-3-16)33-22(23,24)25/h2-5,12-13H,6-11,14H2,1H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Toray Industries Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by ...


Bioorg Med Chem Lett 23: 5975-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.054
BindingDB Entry DOI: 10.7270/Q2TT4SDR
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 2866 total )  |  Next  |  Last  >>
Jump to: