BindingDB PrimarySearch_ki

Found 6954 of ic50 for UniProtKB: Q9NR97

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50586261(CHEMBL5078689)

IC50: 0.0500nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50586259(CHEMBL5090067)

IC50: 0.0800nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50586262(CHEMBL5091113)

IC50: 0.0800nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428547(US10544143, Example 983 | US10730877, Example 983 ...)

IC50: 0.120nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)

IC50: 0.120nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428547(US10544143, Example 983 | US10730877, Example 983 ...)

IC50: 0.120nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428547(US10544143, Example 983 | US10730877, Example 983 ...)

IC50: 0.120nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)

IC50: 0.120nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)

IC50: 0.120nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427673(1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.150nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428465(US10544143, Example 901 | US10730877, Example 901 ...)

IC50: 0.150nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428465(US10544143, Example 901 | US10730877, Example 901 ...)

IC50: 0.150nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428465(US10544143, Example 901 | US10730877, Example 901 ...)

IC50: 0.150nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427673(1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.150nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427673(1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.150nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428633(US10544143, Example 1069 | US10544143, Example 107...)

IC50: 0.170nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428448(US10544143, Example 884 | US10730877, Example 884 ...)

IC50: 0.170nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428448(US10544143, Example 884 | US10730877, Example 884 ...)

IC50: 0.170nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428448(US10544143, Example 884 | US10730877, Example 884 ...)

IC50: 0.170nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428633(US10544143, Example 1069 | US10544143, Example 107...)

IC50: 0.170nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428633(US10544143, Example 1069 | US10544143, Example 107...)

IC50: 0.170nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50586260(CHEMBL5079910)

IC50: 0.200nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428552(US10544143, Example 988 | US10730877, Example 988 ...)

IC50: 0.230nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427618(US10544143, Example 53 | US10730877, Example 53 | ...)

IC50: 0.230nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427618(US10544143, Example 53 | US10730877, Example 53 | ...)

IC50: 0.230nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427618(US10544143, Example 53 | US10730877, Example 53 | ...)

IC50: 0.230nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428552(US10544143, Example 988 | US10730877, Example 988 ...)

IC50: 0.230nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428552(US10544143, Example 988 | US10730877, Example 988 ...)

IC50: 0.230nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428386(US10544143, Example 822 | US10730877, Example 822 ...)

IC50: 0.240nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428386(US10544143, Example 822 | US10730877, Example 822 ...)

IC50: 0.240nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428386(US10544143, Example 822 | US10730877, Example 822 ...)

IC50: 0.240nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427669(US10544143, Example 101 | US10730877, Example 101 ...)

IC50: 0.25nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428528(US10544143, Example 1034 | US10544143, Example 964...)

IC50: 0.25nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427669(US10544143, Example 101 | US10730877, Example 101 ...)

IC50: 0.25nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427822(US10544143, Example 255 | US10544143, Example 256 ...)

IC50: 0.25nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427669(US10544143, Example 101 | US10730877, Example 101 ...)

IC50: 0.25nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427822(US10544143, Example 255 | US10544143, Example 256 ...)

IC50: 0.25nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427822(US10544143, Example 255 | US10544143, Example 256 ...)

IC50: 0.25nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428528(US10544143, Example 1034 | US10544143, Example 964...)

IC50: 0.25nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428528(US10544143, Example 1034 | US10544143, Example 964...)

IC50: 0.25nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427714(US10544143, Example 147 | US10730877, Example 147 ...)

IC50: 0.260nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428472(US10544143, Example 908 | US10730877, Example 908 ...)

IC50: 0.260nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428472(US10544143, Example 908 | US10730877, Example 908 ...)

IC50: 0.260nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427714(US10544143, Example 147 | US10730877, Example 147 ...)

IC50: 0.260nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427714(US10544143, Example 147 | US10730877, Example 147 ...)

IC50: 0.260nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM428472(US10544143, Example 908 | US10730877, Example 908 ...)

IC50: 0.260nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427564(6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...)

IC50: 0.270nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427564(6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...)

IC50: 0.270nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427564(6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...)

IC50: 0.270nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM427663(6-(3-isopropyl-5-(4-methylpiperazin-1-yl)-1H-pyrro...)

IC50: 0.280nMAssay Description:HEK-Blue�-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details US Patent

Displayed 1 to 50 (of 6954 total ) | Next | Last >>

Filter my 6954 hits

Targets 1▿
- Toll-like receptor 8 6954
Publications 29▿
- US Patent US10544143 (2020) 1073
- US Patent US11053244 (2021) 1073
- US Patent US10730877 (2020) 1073
- US Patent US10071079 (2018) 978
- US Patent US10478424 (2019) 978
- US Patent US10660877 (2020) 839
- US Patent US11420958 (2022) 462
- US Patent US11420973 (2022) 213
- J Med Chem 63: 8276-8295 (2020) 55
- ACS Med Chem Lett 13: 812-818 (2022) 34
- J Med Chem 63: 4117-4132 (2020) 31
- ACS Med Chem Lett 13: 658-664 (2022) 28
- J Med Chem 62: 10221-10244 (2019) 27
- Bioorg Med Chem Lett 30: (2020) 14
- J Med Chem 55: 1106-16 (2012) 11
- Eur J Med Chem 225: (2021) 9
- Bioorg Med Chem Lett 44: (2021) 8
- J Med Chem 59: 3311-30 (2016) 8
- ACS Med Chem Lett 12: 1208-1209 (2021) 6
- ACS Med Chem Lett 12: 1071-1072 (2021) 6
- ACS Med Chem Lett 12: 1359-1360 (2021) 6
- ACS Med Chem Lett 12: 7-8 (2021) 6
- J Med Chem 64: 9279-9301 (2021) 4
- ACS Med Chem Lett 11: 1751-1758 (2020) 3
- Eur J Med Chem 179: 744-752 (2019) 3
- J Med Chem 65: 11607-11632 (2022) 2
- Bioorg Med Chem Lett 59: (2022) 2
- J Med Chem 63: 13466-13513 (2020) 1
- ACS Med Chem Lett 5: 1235-9 (2014) 1
Institutions 16▿
- Bristol-Myers Squibb 6689
- Genomics Institute Of The Novartis Research Foundation 69
- Biocon Bristol Myers Squibb Research Center (Bbrc) 34
- The University Of Tokyo 31
- Novartis Institutes For Biomedical Research 28
- University Of Colorado Boulder 27
- Smith, Gambrell & Russell 24
- University Of Kansas 19
- University Of Ljubljana 9
- Roche Innovation Center Shanghai 8
- Csir-Indian Institute Of Chemical Biology 6
- Princ 3
- Freie Universit£T Berlin 3
- University Of Minnesota 2
- Sumitomo Dainippon Pharma 1
- University Of Siena 1
Affinity: 0.050 to 1.0E+5 nM▿
- IC50 6954
- Affinity ≤ nM
Xtal structures: 9
Docked structures: 0
Catalog Cmpds: 14