Compile Data Set for Download or QSAR

Found 26 hits Enz. Inhib. hit(s) with all data for entry = 10003   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507023 (US11046671, VTX-133) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cccnc1 Show InChI InChI=1S/C22H26N4O/c1-3-10-26(11-4-2)22(27)19-12-17-8-7-16(18-6-5-9-24-15-18)13-20(17)25-21(23)14-19/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,23,25)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	77	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507050 (2-Amino-8-(6-methoxy-1,4-dihydroquinazolin-2-yl)-N...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2cc(OC)ccc2N1 Show InChI InChI=1S/C26H31N5O2/c1-4-10-31(11-5-2)26(32)19-12-17-6-7-18(14-23(17)29-24(27)15-19)25-28-16-20-13-21(33-3)8-9-22(20)30-25/h6-9,12-14H,4-5,10-11,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507033 (US11046671, VTX-135) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cncnc1 Show InChI InChI=1S/C21H25N5O/c1-3-7-26(8-4-2)21(27)17-9-16-6-5-15(18-12-23-14-24-13-18)10-19(16)25-20(22)11-17/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,22,25)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507033 (US11046671, VTX-135) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cncnc1 Show InChI InChI=1S/C21H25N5O/c1-3-7-26(8-4-2)21(27)17-9-16-6-5-15(18-12-23-14-24-13-18)10-19(16)25-20(22)11-17/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,22,25)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.61E+3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507035 (2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N,N-dipropy...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C25H29N5O/c1-3-11-30(12-4-2)25(31)20-13-17-9-10-18(14-22(17)28-23(26)15-20)24-27-16-19-7-5-6-8-21(19)29-24/h5-10,13-14H,3-4,11-12,15-16H2,1-2H3,(H2,26,28)(H,27,29)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507035 (2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N,N-dipropy...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C25H29N5O/c1-3-11-30(12-4-2)25(31)20-13-17-9-10-18(14-22(17)28-23(26)15-20)24-27-16-19-7-5-6-8-21(19)29-24/h5-10,13-14H,3-4,11-12,15-16H2,1-2H3,(H2,26,28)(H,27,29)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507039 (2-Amino-8-(1,4-dihydropyrido[3,4-d]pyrimidin-2-yl)...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccncc2N1 Show InChI InChI=1S/C24H28N6O/c1-3-9-30(10-4-2)24(31)19-11-16-5-6-17(12-20(16)28-22(25)13-19)23-27-14-18-7-8-26-15-21(18)29-23/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3,(H2,25,28)(H,27,29)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507039 (2-Amino-8-(1,4-dihydropyrido[3,4-d]pyrimidin-2-yl)...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccncc2N1 Show InChI InChI=1S/C24H28N6O/c1-3-9-30(10-4-2)24(31)19-11-16-5-6-17(12-20(16)28-22(25)13-19)23-27-14-18-7-8-26-15-21(18)29-23/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3,(H2,25,28)(H,27,29)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507042 (2-Amino-N-(cyclopropylmethyl)-8-(1,4-dihydroquinaz...) Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C26H29N5O/c1-2-11-31(16-17-7-8-17)26(32)21-12-18-9-10-19(13-23(18)29-24(27)14-21)25-28-15-20-5-3-4-6-22(20)30-25/h3-6,9-10,12-13,17H,2,7-8,11,14-16H2,1H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507042 (2-Amino-N-(cyclopropylmethyl)-8-(1,4-dihydroquinaz...) Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C26H29N5O/c1-2-11-31(16-17-7-8-17)26(32)21-12-18-9-10-19(13-23(18)29-24(27)14-21)25-28-15-20-5-3-4-6-22(20)30-25/h3-6,9-10,12-13,17H,2,7-8,11,14-16H2,1H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507043 (2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N-isobutyl-...) Show SMILES CCCN(CC(C)C)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-11-31(16-17(2)3)26(32)21-12-18-9-10-19(13-23(18)29-24(27)14-21)25-28-15-20-7-5-6-8-22(20)30-25/h5-10,12-13,17H,4,11,14-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507043 (2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N-isobutyl-...) Show SMILES CCCN(CC(C)C)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-11-31(16-17(2)3)26(32)21-12-18-9-10-19(13-23(18)29-24(27)14-21)25-28-15-20-7-5-6-8-22(20)30-25/h5-10,12-13,17H,4,11,14-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507044 (2-Amino-8-(5-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(C)cccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-11-31(12-5-2)26(32)20-13-18-9-10-19(14-23(18)29-24(27)15-20)25-28-16-21-17(3)7-6-8-22(21)30-25/h6-10,13-14H,4-5,11-12,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507044 (2-Amino-8-(5-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(C)cccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-11-31(12-5-2)26(32)20-13-18-9-10-19(14-23(18)29-24(27)15-20)25-28-16-21-17(3)7-6-8-22(21)30-25/h6-10,13-14H,4-5,11-12,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507045 (2-Amino-8-(7-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccc(Cl)cc2N1 Show InChI InChI=1S/C25H28ClN5O/c1-3-9-31(10-4-2)25(32)19-11-16-5-6-17(12-21(16)29-23(27)13-19)24-28-15-18-7-8-20(26)14-22(18)30-24/h5-8,11-12,14H,3-4,9-10,13,15H2,1-2H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507045 (2-Amino-8-(7-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccc(Cl)cc2N1 Show InChI InChI=1S/C25H28ClN5O/c1-3-9-31(10-4-2)25(32)19-11-16-5-6-17(12-21(16)29-23(27)13-19)24-28-15-18-7-8-20(26)14-22(18)30-24/h5-8,11-12,14H,3-4,9-10,13,15H2,1-2H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507046 (2-Amino-8-(4,4-dimethyl-1H-quinazolin-2-yl)-N,N-di...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NC(C)(C)c2ccccc2N1 Show InChI InChI=1S/C27H33N5O/c1-5-13-32(14-6-2)26(33)20-15-18-11-12-19(16-23(18)29-24(28)17-20)25-30-22-10-8-7-9-21(22)27(3,4)31-25/h7-12,15-16H,5-6,13-14,17H2,1-4H3,(H2,28,29)(H,30,31)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507046 (2-Amino-8-(4,4-dimethyl-1H-quinazolin-2-yl)-N,N-di...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NC(C)(C)c2ccccc2N1 Show InChI InChI=1S/C27H33N5O/c1-5-13-32(14-6-2)26(33)20-15-18-11-12-19(16-23(18)29-24(28)17-20)25-30-22-10-8-7-9-21(22)27(3,4)31-25/h7-12,15-16H,5-6,13-14,17H2,1-4H3,(H2,28,29)(H,30,31)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507047 (2-Amino-8-(6-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2cc(C)ccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-10-31(11-5-2)26(32)20-13-18-7-8-19(14-23(18)29-24(27)15-20)25-28-16-21-12-17(3)6-9-22(21)30-25/h6-9,12-14H,4-5,10-11,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507047 (2-Amino-8-(6-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2cc(C)ccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-10-31(11-5-2)26(32)20-13-18-7-8-19(14-23(18)29-24(27)15-20)25-28-16-21-12-17(3)6-9-22(21)30-25/h6-9,12-14H,4-5,10-11,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507044 (2-Amino-8-(5-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(C)cccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-11-31(12-5-2)26(32)20-13-18-9-10-19(14-23(18)29-24(27)15-20)25-28-16-21-17(3)7-6-8-22(21)30-25/h6-10,13-14H,4-5,11-12,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507044 (2-Amino-8-(5-chloro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(C)cccc2N1 Show InChI InChI=1S/C26H31N5O/c1-4-11-31(12-5-2)26(32)20-13-18-9-10-19(14-23(18)29-24(27)15-20)25-28-16-21-17(3)7-6-8-22(21)30-25/h6-10,13-14H,4-5,11-12,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507049 (2-Amino-8-(5-fluoro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(F)cccc2N1 Show InChI InChI=1S/C25H28FN5O/c1-3-10-31(11-4-2)25(32)18-12-16-8-9-17(13-22(16)29-23(27)14-18)24-28-15-19-20(26)6-5-7-21(19)30-24/h5-9,12-13H,3-4,10-11,14-15H2,1-2H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507049 (2-Amino-8-(5-fluoro-1,4-dihydroquinazolin-2-yl)-N,...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(F)cccc2N1 Show InChI InChI=1S/C25H28FN5O/c1-3-10-31(11-4-2)25(32)18-12-16-8-9-17(13-22(16)29-23(27)14-18)24-28-15-19-20(26)6-5-7-21(19)30-24/h5-9,12-13H,3-4,10-11,14-15H2,1-2H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507050 (2-Amino-8-(6-methoxy-1,4-dihydroquinazolin-2-yl)-N...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2cc(OC)ccc2N1 Show InChI InChI=1S/C26H31N5O2/c1-4-10-31(11-5-2)26(32)19-12-17-6-7-18(14-23(17)29-24(27)15-19)25-28-16-20-13-21(33-3)8-9-22(20)30-25/h6-9,12-14H,4-5,10-11,15-16H2,1-3H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507023 (US11046671, VTX-133) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cccnc1 Show InChI InChI=1S/C22H26N4O/c1-3-10-26(11-4-2)22(27)19-12-17-8-7-16(18-6-5-9-24-15-18)13-20(17)25-21(23)14-19/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,23,25)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair