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Compile Data Set for Download or QSAR

Found 329 hits Enz. Inhib. hit(s) with all data for entry = 6019   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104202
PNG
(US8575145, 79)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccc(cn23)C2CC2)CCNCC1
Show InChI InChI=1S/C24H24FN5O/c25-24(10-12-26-13-11-24)15-31-20-3-1-2-17-6-8-19(27-22(17)20)23-29-28-21-9-7-18(14-30(21)23)16-4-5-16/h1-3,6-9,14,16,26H,4-5,10-13,15H2
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US Patent
n/an/a 0.200n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 0.400n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104204
PNG
(US8575145, 81)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccc(cn23)-c2ccccc2)CCNCC1
Show InChI InChI=1S/C27H24FN5O/c28-27(13-15-29-16-14-27)18-34-23-8-4-7-20-9-11-22(30-25(20)23)26-32-31-24-12-10-21(17-33(24)26)19-5-2-1-3-6-19/h1-12,17,29H,13-16,18H2
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n/an/a 0.450n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 0.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104229
PNG
(US8575145, 106)
Show SMILES Fc1cc(OCC2(F)CCNCC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-15-11-14-4-5-16(20-27-26-18-3-1-2-10-28(18)20)25-19(14)17(12-15)29-13-21(23)6-8-24-9-7-21/h1-5,10-12,24H,6-9,13H2
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n/an/a 0.5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104162
PNG
(US8575145, 39)
Show SMILES CC(C)(CN)COc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20FN5O/c1-20(2,11-22)12-27-16-10-14(21)9-13-6-7-15(23-18(13)16)19-25-24-17-5-3-4-8-26(17)19/h3-10H,11-12,22H2,1-2H3
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n/an/a 0.550n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104187
PNG
(US8575145, 64)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1
Show InChI InChI=1S/C23H25N5O/c1-23(2,13-24)14-29-19-5-3-4-16-8-10-18(25-21(16)19)22-27-26-20-11-9-17(12-28(20)22)15-6-7-15/h3-5,8-12,15H,6-7,13-14,24H2,1-2H3
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n/an/a 0.640n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104140
PNG
(US8575145, 17)
Show SMILES NC1CCC(CC1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O/c22-15-8-10-16(11-9-15)27-18-5-3-4-14-7-12-17(23-20(14)18)21-25-24-19-6-1-2-13-26(19)21/h1-7,12-13,15-16H,8-11,22H2
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n/an/a 0.650n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104186
PNG
(US8575145, 63)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(Br)cn12
Show InChI InChI=1S/C20H20BrN5O/c1-20(2,11-22)12-27-16-5-3-4-13-6-8-15(23-18(13)16)19-25-24-17-9-7-14(21)10-26(17)19/h3-10H,11-12,22H2,1-2H3
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n/an/a 0.650n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 0.700n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104142
PNG
(US8575145, 19)
Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12
Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3
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n/an/a 0.700n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104237
PNG
(US8575145, 114)
Show SMILES COC1(COc2cc(F)cc3ccc(nc23)-c2nnc3ccccn23)CCCNCC1
Show InChI InChI=1S/C23H24FN5O2/c1-30-23(8-4-10-25-11-9-23)15-31-19-14-17(24)13-16-6-7-18(26-21(16)19)22-28-27-20-5-2-3-12-29(20)22/h2-3,5-7,12-14,25H,4,8-11,15H2,1H3
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n/an/a 0.700n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104221
PNG
(US8575145, 98)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1
Show InChI InChI=1S/C24H24FN5O/c25-18-10-12-26-13-11-20(18)31-21-3-1-2-16-6-8-19(27-23(16)21)24-29-28-22-9-7-17(14-30(22)24)15-4-5-15/h1-3,6-9,14-15,18,20,26H,4-5,10-13H2
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n/an/a 0.700n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104193
PNG
(US8575145, 70)
Show SMILES CC(C)C1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C24H27N5O/c1-17(2)24(11-13-25-14-12-24)16-30-20-7-5-6-18-9-10-19(26-22(18)20)23-28-27-21-8-3-4-15-29(21)23/h3-10,15,17,25H,11-14,16H2,1-2H3
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n/an/a 0.75n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104165
PNG
(US8575145, 42)
Show SMILES N[C@H]1CCC(CC1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H21N5O/c22-15-8-10-16(11-9-15)27-18-5-3-4-14-7-12-17(23-20(14)18)21-25-24-19-6-1-2-13-26(19)21/h1-7,12-13,15-16H,8-11,22H2/t15-,16?
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n/an/a 0.75n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104188
PNG
(US8575145, 65)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(cn12)-c1ccccc1
Show InChI InChI=1S/C26H25N5O/c1-26(2,16-27)17-32-22-10-6-9-19-11-13-21(28-24(19)22)25-30-29-23-14-12-20(15-31(23)25)18-7-4-3-5-8-18/h3-15H,16-17,27H2,1-2H3
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n/an/a 0.800n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104147
PNG
(US8575145, 24)
Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20N4O2/c1-20(2,12-25)13-26-16-7-5-6-14-9-10-15(21-18(14)16)19-23-22-17-8-3-4-11-24(17)19/h3-11,25H,12-13H2,1-2H3
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n/an/a 0.800n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 0.800n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 0.800n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 0.900n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104246
PNG
(US8575145, 123)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OCC(C)(C)CN)c2n1
Show InChI InChI=1S/C21H23N5O/c1-14-9-10-26-18(11-14)24-25-20(26)16-8-7-15-5-4-6-17(19(15)23-16)27-13-21(2,3)12-22/h4-11H,12-13,22H2,1-3H3
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n/an/a 0.900n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 0.920n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104190
PNG
(US8575145, 67)
Show SMILES CC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O/c1-22(10-12-23-13-11-22)15-28-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
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n/an/a 0.950n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104196
PNG
(US8575145, 73)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O2/c1-28-22(10-12-23-13-11-22)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
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n/an/a 0.960n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104139
PNG
(US8575145, 16)
Show SMILES C(Oc1cccc2ccc(nc12)-c1nnc2ccccn12)C1CCCNC1
Show InChI InChI=1S/C21H21N5O/c1-2-12-26-19(8-1)24-25-21(26)17-10-9-16-6-3-7-18(20(16)23-17)27-14-15-5-4-11-22-13-15/h1-3,6-10,12,15,22H,4-5,11,13-14H2
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104240
PNG
(US8575145, 117)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCCNCC1
Show InChI InChI=1S/C23H25N5O2/c1-29-23(11-5-13-24-14-12-23)16-30-19-7-4-6-17-9-10-18(25-21(17)19)22-27-26-20-8-2-3-15-28(20)22/h2-4,6-10,15,24H,5,11-14,16H2,1H3
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104248
PNG
(US8575145, 125)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3cc(C)ccn23)CCNCC1
Show InChI InChI=1S/C23H25N5O2/c1-16-8-13-28-20(14-16)26-27-22(28)18-7-6-17-4-3-5-19(21(17)25-18)30-15-23(29-2)9-11-24-12-10-23/h3-8,13-14,24H,9-12,15H2,1-2H3
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104255
PNG
(US8575145, 132)
Show SMILES CC(C)(CCN)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H23N5O/c1-21(2,11-12-22)14-27-17-7-5-6-15-9-10-16(23-19(15)17)20-25-24-18-8-3-4-13-26(18)20/h3-10,13H,11-12,14,22H2,1-2H3
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104191
PNG
(US8575145, 68)
Show SMILES CCC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C23H25N5O/c1-2-23(11-13-24-14-12-23)16-29-19-7-5-6-17-9-10-18(25-21(17)19)22-27-26-20-8-3-4-15-28(20)22/h3-10,15,24H,2,11-14,16H2,1H3
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n/an/a 1.30n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104241
PNG
(US8575145, 118/119 | US8575145, 149)
Show SMILES CN1CCC(F)C(CC1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C22H22FN5O/c1-27-13-10-16(23)18(11-14-27)29-19-6-4-5-15-8-9-17(24-21(15)19)22-26-25-20-7-2-3-12-28(20)22/h2-9,12,16,18H,10-11,13-14H2,1H3
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n/an/a 1.30n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104238
PNG
(US8575145, 115)
Show SMILES COC1(COc2cc(F)cc3ccc(nc23)-c2nnc3ccccn23)CCCN(CCO)CC1
Show InChI InChI=1S/C25H28FN5O3/c1-33-25(8-4-10-30(12-9-25)13-14-32)17-34-21-16-19(26)15-18-6-7-20(27-23(18)21)24-29-28-22-5-2-3-11-31(22)24/h2-3,5-7,11,15-16,32H,4,8-10,12-14,17H2,1H3
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n/an/a 1.40n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104226
PNG
(US8575145, 103)
Show SMILES Fc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1
Show InChI InChI=1S/C21H19F2N5O/c22-15-5-7-18-26-27-20(28(18)12-15)16-6-4-14-2-1-3-17(19(14)25-16)29-13-21(23)8-10-24-11-9-21/h1-7,12,24H,8-11,13H2
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n/an/a 1.40n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104141
PNG
(US8575145, 18)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H21N5O/c1-20(2,12-21)13-26-16-7-5-6-14-9-10-15(22-18(14)16)19-24-23-17-8-3-4-11-25(17)19/h3-11H,12-13,21H2,1-2H3
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n/an/a 1.5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 1.5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104256
PNG
(US8575145, 133)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCCNC1
Show InChI InChI=1S/C21H20FN5O/c22-21(10-4-11-23-13-21)14-28-17-6-3-5-15-8-9-16(24-19(15)17)20-26-25-18-7-1-2-12-27(18)20/h1-3,5-9,12,23H,4,10-11,13-14H2
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n/an/a 1.60n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104192
PNG
(US8575145, 69)
Show SMILES C(Oc1cccc2ccc(nc12)-c1nnc2ccccn12)C1(CC2CC2)CCNCC1
Show InChI InChI=1S/C25H27N5O/c1-2-15-30-22(6-1)28-29-24(30)20-10-9-19-4-3-5-21(23(19)27-20)31-17-25(16-18-7-8-18)11-13-26-14-12-25/h1-6,9-10,15,18,26H,7-8,11-14,16-17H2
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n/an/a 1.60n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104124
PNG
(US8575145, 1)
Show SMILES C1CC(CCN1)Nc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20N6/c1-2-13-26-18(6-1)24-25-20(26)17-8-7-14-4-3-5-16(19(14)23-17)22-15-9-11-21-12-10-15/h1-8,13,15,21-22H,9-12H2
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n/an/a 1.60n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104233
PNG
(US8575145, 110)
Show SMILES COc1ccc2nnc(-c3ccc4cc(F)cc(OCC5(F)CCNCC5)c4n3)n2c1
Show InChI InChI=1S/C22H21F2N5O2/c1-30-16-3-5-19-27-28-21(29(19)12-16)17-4-2-14-10-15(23)11-18(20(14)26-17)31-13-22(24)6-8-25-9-7-22/h2-5,10-12,25H,6-9,13H2,1H3
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n/an/a 1.90n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Rattus norvegicus (Rat))
BDBM104169
PNG
(US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104208
PNG
(US8575145, 85)
Show SMILES OCCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O2/c24-23(9-12-28(13-10-23)14-15-30)16-31-19-5-3-4-17-7-8-18(25-21(17)19)22-27-26-20-6-1-2-11-29(20)22/h1-8,11,30H,9-10,12-16H2
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Rattus norvegicus (Rat))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104207
PNG
(US8575145, 84)
Show SMILES CN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C22H22FN5O/c1-27-13-10-22(23,11-14-27)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-12-28(19)21/h2-9,12H,10-11,13-15H2,1H3
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Rattus norvegicus (Rat))
BDBM104141
PNG
(US8575145, 18)
Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H21N5O/c1-20(2,12-21)13-26-16-7-5-6-14-9-10-15(22-18(14)16)19-24-23-17-8-3-4-11-25(17)19/h3-11H,12-13,21H2,1-2H3
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Rattus norvegicus (Rat))
BDBM104142
PNG
(US8575145, 19)
Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12
Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104137
PNG
(US8575145, 14)
Show SMILES C(Oc1cccc2ccc(nc12)-c1nnc2ccccn12)C1CCNCC1
Show InChI InChI=1S/C21H21N5O/c1-2-13-26-19(6-1)24-25-21(26)17-8-7-16-4-3-5-18(20(16)23-17)27-14-15-9-11-22-12-10-15/h1-8,13,15,22H,9-12,14H2
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104143
PNG
(US8575145, 20)
Show SMILES CC(C)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12
Show InChI InChI=1S/C20H21N5O/c1-13(2)12-26-17-5-3-4-15-6-7-16(22-19(15)17)20-24-23-18-10-14(11-21)8-9-25(18)20/h3-10,13H,11-12,21H2,1-2H3
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104146
PNG
(US8575145, 23)
Show SMILES CC(C)(C)COc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H20N4O/c1-20(2,3)13-25-16-8-6-7-14-10-11-15(21-18(14)16)19-23-22-17-9-4-5-12-24(17)19/h4-12H,13H2,1-3H3
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US Patent
n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
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