Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 2217
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  2.80nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18162((1R,6R,7S)-4-(4-nitronaphthalen-1-yl)-2,4-diazatri...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole EC50:  385nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18165((6R)-6-hydroxy-2-(4-nitronaphthalen-1-yl)-hexahydr...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole EC50:  320nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18169((7S,7aR)-7-hydroxy-2-(4-nitronaphthalen-1-yl)-hexa...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole EC50:  281nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18164(2-(4-nitronaphthalen-1-yl)-hexahydro-1H-pyrrolo[1,...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/mole EC50:  270nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18168((7R,7aS)-7-hydroxy-2-(4-nitronaphthalen-1-yl)-hexa...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/mole EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18171(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/mole EC50:  2.30nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18167(4-(Tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c...)
Affinity DataKi:  3.5nM ΔG°:  -47.8kJ/mole EC50:  4.40nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18166((6S)-6-hydroxy-2-(4-nitronaphthalen-1-yl)-hexahydr...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole EC50:  265nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18172(4-[(7S,7aR)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  5.30nM ΔG°:  -46.8kJ/mole IC50:  60nM EC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18170(4-{7-hydroxy-1,3-dioxo-hexahydro-1H-pyrrolo[1,2-a]...)
Affinity DataKi:  5.5nM ΔG°:  -46.7kJ/mole EC50:  6.30nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18163(4-[(1R,6R,7S)-3,5-dioxo-2,4-diazatricyclo[5.2.1.0^...)
Affinity DataKi:  24nM ΔG°:  -43.1kJ/mole IC50:  260nM EC50: >1.00E+3nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed