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Found 14 Enz. Inhib. hit(s) with all data for entry = 50006313
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50047471((S)-N-tert-butyl-3-(4-(2-methoxyphenyl)piperazin-1...)
Affinity DataIC50:  16nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 1A receptor was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50:  24nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 1A receptor was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50047472((R)-N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin...)
Affinity DataIC50:  34nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 1A receptor was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50:  265nMAssay Description:In vitro binding affinity towards the dopamine receptor D2 at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50456023(CHEMBL289981)
Affinity DataIC50:  437nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 1A receptor was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 1C receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity towards the noradrenergic beta receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity towards the noradrenergic alpha-2 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity towards the noradrenergic alpha-1 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50047471((S)-N-tert-butyl-3-(4-(2-methoxyphenyl)piperazin-1...)
Affinity DataIC50:  1.39E+3nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 2 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50047472((R)-N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin...)
Affinity DataIC50:  1.49E+3nMAssay Description:In vitro binding affinity towards the anor-adrenergic alpha-1 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50047471((S)-N-tert-butyl-3-(4-(2-methoxyphenyl)piperazin-1...)
Affinity DataIC50:  1.88E+3nMAssay Description:In vitro binding affinity towards the alpha-1 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50:  2.15E+3nMAssay Description:In vitro binding affinity towards the 5-hydroxytryptamine 2 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Wyeth Research (Uk)

Curated by ChEMBL
LigandPNGBDBM50456023(CHEMBL289981)
Affinity DataIC50:  2.78E+3nMAssay Description:In vitro binding affinity towards the noradrenergic alpha-1 receptor at 10 e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed