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Found 18 Enz. Inhib. hit(s) with all data for entry = 50030318
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294219((3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzy...)
Affinity DataIC50:  27nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294219((3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzy...)
Affinity DataIC50:  45nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29754(macrocyclic peptidomimetic, 3h)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29750(macrocyclic peptidomimetic, 3d)
Affinity DataIC50:  250nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29744(hydroxyethylene tripeptide inhibitor, 1)
Affinity DataIC50:  370nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294219((3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzy...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29744(hydroxyethylene tripeptide inhibitor, 1)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29750(macrocyclic peptidomimetic, 3d)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29754(macrocyclic peptidomimetic, 3h)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29754(macrocyclic peptidomimetic, 3h)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29744(hydroxyethylene tripeptide inhibitor, 1)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29750(macrocyclic peptidomimetic, 3d)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair