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Found 44 Enz. Inhib. hit(s) with all data for entry = 50035935
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  0.480nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009844(2-fluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imi...)
Affinity DataIC50:  27nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity was measured against renal inner medulla aldehyde reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009835(4-Hydroxy-5-oxo-1-pyridin-4-ylmethyl-2,5-dihydro-1...)
Affinity DataIC50:  110nMAssay Description:Percent inhibition of sorbitol accumulation in rat lens was measuredChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009835(4-Hydroxy-5-oxo-1-pyridin-4-ylmethyl-2,5-dihydro-1...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009845(1-(3,4-Dichloro-benzyl)-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009833(1-(9H-Fluoren-9-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009844(2-fluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imi...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009849(1-(4-Chloro-benzyl)-4-hydroxy-5-oxo-2,5-dihydro-1H...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009837(4-Hydroxy-5-oxo-1-thiophen-2-ylmethyl-2,5-dihydro-...)
Affinity DataIC50:  380nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009851(4-Hydroxy-1-(4-methoxy-benzyl)-5-oxo-2,5-dihydro-1...)
Affinity DataIC50:  410nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009830(4-Hydroxy-5-oxo-1-pyridin-2-ylmethyl-2,5-dihydro-1...)
Affinity DataIC50:  440nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009831(1-(4-Bromo-benzyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  540nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009848(4-Hydroxy-5-oxo-1-(1-phenyl-ethyl)-2,5-dihydro-1H-...)
Affinity DataIC50:  840nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009847(CHEMBL428672 | ethyl 6-fluoro-4',5'-dioxospiro[3,4...)
Affinity DataIC50:  910nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009836(4-Hydroxy-5-oxo-1-(1-phenyl-ethyl)-2,5-dihydro-1H-...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  1.32E+3nMAssay Description:Percent inhibition of sorbitol accumulation in rat lens was measuredChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  1.50E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009838(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  1.90E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity measured against pig kidney aldehyde reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  2.00E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009843(4-Hydroxy-1-naphthalen-1-ylmethyl-5-oxo-2,5-dihydr...)
Affinity DataIC50:  2.30E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009846(1-(2-Chloro-benzyl)-4-hydroxy-5-oxo-2,5-dihydro-1H...)
Affinity DataIC50:  2.30E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009850(4-Hydroxy-5-oxo-1-phenethyl-2,5-dihydro-1H-pyrrole...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009840(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009842(1-Furan-2-ylmethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-...)
Affinity DataIC50:  3.30E+3nMAssay Description:In vitro inhibition of human placental aldose reductase.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  3.65E+3nMAssay Description:Inhibitory activity was measured against pig kidney aldehyde reductase in the presence of 1 uM compound with 3-pyridine carboxaldehyde as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity was measured against whole kidney aldehyde reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  3.54E+4nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with DL-glyceraldehyde as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009839(2-Methyl-1,4-dioxo-1,2,3,4-tetrahydro-naphthalene-...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009834(2-Propylvaleric acid sodium salt | CHEMBL433 | Dep...)
Affinity DataIC50:  8.90E+4nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibitory activity was measured against renal outer medulla aldehyde reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009834(2-Propylvaleric acid sodium salt | CHEMBL433 | Dep...)
Affinity DataIC50:  3.80E+5nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  4.80E+5nMAssay Description:Inhibitory activity was measured against renal cortex aldehyde reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009839(2-Methyl-1,4-dioxo-1,2,3,4-tetrahydro-naphthalene-...)
Affinity DataIC50:  4.90E+5nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed