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Found 41 Enz. Inhib. hit(s) with all data for entry = 50037186
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131975(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  3.10nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131980(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  6nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131975(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  6.5nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131982(2-Acetylamino-4-methyl-pentanoic acid [1-(benzothi...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131989(1-Acetyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid ...)
Affinity DataKi:  9.10nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131983(1-Acetyl-4-oxo-pyrrolidine-2-carboxylic acid [1-(b...)
Affinity DataKi:  9.90nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131985(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  16nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131980(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  19nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131984(1-Acetyl-azetidine-2-carboxylic acid [1-(benzothia...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  22nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131979(CHEMBL340547 | Cyclopentanecarboxylic acid [1-(ben...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131988(2-[1-(Benzothiazole-2-carbonyl)-4-guanidino-butylc...)
Affinity DataKi:  33nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131989(1-Acetyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid ...)
Affinity DataKi:  38nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131988(2-[1-(Benzothiazole-2-carbonyl)-4-guanidino-butylc...)
Affinity DataKi:  38nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131982(2-Acetylamino-4-methyl-pentanoic acid [1-(benzothi...)
Affinity DataKi:  41nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131984(1-Acetyl-azetidine-2-carboxylic acid [1-(benzothia...)
Affinity DataKi:  53nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131983(1-Acetyl-4-oxo-pyrrolidine-2-carboxylic acid [1-(b...)
Affinity DataKi:  73nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131974(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  81nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131979(CHEMBL340547 | Cyclopentanecarboxylic acid [1-(ben...)
Affinity DataKi:  88nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131985(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  90nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  100nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  140nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131978(1-Benzyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  160nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  170nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  170nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131974(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  180nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131978(1-Benzyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  250nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131981(CHEMBL340098 | N-{[1-(Benzothiazole-2-carbonyl)-4-...)
Affinity DataKi:  260nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131987(1-{5-Guanidino-2-[(1-hydroxy-naphthalene-2-carbony...)
Affinity DataKi:  330nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  380nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  380nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131981(CHEMBL340098 | N-{[1-(Benzothiazole-2-carbonyl)-4-...)
Affinity DataKi:  470nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  960nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  1.40E+4nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131988(2-[1-(Benzothiazole-2-carbonyl)-4-guanidino-butylc...)
Affinity DataIC50:  1nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of compound was determined against human Tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131981(CHEMBL340098 | N-{[1-(Benzothiazole-2-carbonyl)-4-...)
Affinity DataIC50:  2nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50:  4nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131984(1-Acetyl-azetidine-2-carboxylic acid [1-(benzothia...)
Affinity DataIC50:  5nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131978(1-Benzyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50:  8nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed