Compile Data Set for Download or QSAR
maximum 50k data
Found 25 Enz. Inhib. hit(s) with all data for entry = 50039197
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321368(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321373(4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321367(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321365(4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321364(4-cyano-N-(2-(4,4-dimethylcyclohex-1-enyl)-4-(2,6-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321369(4-cyano-N-(2-cycloheptenyl-4-(1,3-dimethyl-2-oxohe...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321363(4-cyano-N-(2-cyclohexenyl-4-(2,6-dioxopiperidin-4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321354(3-(4-(4-cyano-1H-imidazole-2-carboxamido)-3-cycloh...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321352(4-(4-(4-cyano-1H-imidazole-2-carboxamido)-3-cycloh...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321371(4-Cyano-1H-imidazole-2-carboxylicacid[2-cyclohex-1...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321374(4-cyano-N-(4-(1,3-dimethyl-2-(methylsulfonylimino)...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321355(4-cyano-N-(2-cyclohexenyl-4-(pyridin-3-yl)phenyl)-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321366(4-cyano-N-(2-cyclohexenyl-4-(2-oxohexahydropyrimid...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321372(4-cyano-N-(4-(2-(cyanoimino)hexahydropyrimidin-5-y...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321370(4-Cyano-1H-imidazole-2-carboxylicacid[2-cyclohex-1...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321353(4-cyano-N-(2-cyclohexenyl-4-(pyridin-4-yl)phenyl)-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321353(4-cyano-N-(2-cyclohexenyl-4-(pyridin-4-yl)phenyl)-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321358(CHEMBL1172313 | N-(4-(6-aminopyridin-3-yl)-2-cyclo...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321356(2-(4-(4-cyano-1H-imidazole-2-carboxamido)-3-cycloh...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321357(4-cyano-N-(2-cyclohexenyl-4-(pyridin-2-yl)phenyl)-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321360(4-cyano-N-(3-cyclohexenyl-4'-(N,N-dimethylsulfamoy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321361(CHEMBL1172530 | N-(4'-amino-3-cyclohexenylbiphenyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321359(4-cyano-N-(2-(4,4-dimethylcyclohex-1-enyl)-4-(6-me...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321362(4-cyano-N-(3-cyclohexenylbiphenyl-4-yl)-1H-imidazo...)
Affinity DataIC50: >60nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321353(4-cyano-N-(2-cyclohexenyl-4-(pyridin-4-yl)phenyl)-...)
Affinity DataIC50:  87nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed