Compile Data Set for Download or QSAR
maximum 50k data
Found 62 Enz. Inhib. hit(s) with all data for entry = 50040549
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50300041(7-(3-(dimethylamino)propoxy)-6-methoxy-2-(4-methyl...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human recombinant G9a catalytic domain amino acid 913 to 1193 expressed in Escherichia coli BL21 (DE3) by isothermal titration ca...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKi:  3.70nMAssay Description:Competitive inhibition of G9a by fluorescence polarization assay in presence of fluorescein-labeled H3 peptideMore data for this Ligand-Target Pair
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396022(CHEMBL2169920)
Affinity DataKi:  300nMAssay Description:Competitive binding affinity to full length human SMYD2 amino acid 1 to 433 expressed in Escherichia coli BL21 (DE3) after 90 mins by radioactive fil...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataKi:  300nMAssay Description:Inhibition of human recombinant DOT1L using [3H]-SAM as substrate after 30 minsMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396014(CHEMBL2169888)
Affinity DataKi:  610nMAssay Description:Inhibition of LSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396015(CHEMBL2169921)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human LSD1 using histone H3 peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50346874(CHEMBL1797649)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of recombinant LSD1 catalytic domain amino acid 178 to 831 expressed in Sf9 cells infected with baculovirus using diMeK4H3-21 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50346862(CHEMBL1215658)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of N terminal hexahistidine-tag recombinant human LSD1 expressed in Escherichia coli BL21 (DE3) using histone H3 peptide as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50346534(CHEMBL1797705)
Affinity DataKi:  5.70E+3nMAssay Description:Inhibition of N terminal hexahistidine-tag recombinant human LSD1 expressed in Escherichia coli BL21 (DE3) using histone H3 peptide as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50346865(2-PFPA | CHEMBL1797642)
Affinity DataKi:  8.90E+3nMAssay Description:Inhibition of LSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of human LSD1 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant DOT1L using [3H]-SAM as substrate after 30 minsMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  19nMAssay Description:Competitive inhibition of GLP by fluorescence polarization assay in presence of fluorescein-labeled H3 peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396027(CHEMBL499593)
Affinity DataIC50:  66nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of G9a in human MCF7 cells after 48 hrs by clonogenic assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells after 48 hrs by clonogenic assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396019(4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of JMJD2E catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396016(CHEMBL2169918)
Affinity DataIC50:  110nMAssay Description:Inhibition of GST-tagged human DOT1L amino acid 1 to 472 expressed in Escherichia coli BL21 (DE3) using [3H]-SAM as substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396017(CHEMBL2172427)
Affinity DataIC50:  120nMAssay Description:Inhibition of GST-tagged human DOT1L amino acid 1 to 472 expressed in Escherichia coli BL21 (DE3) using [3H]-SAM as substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396022(CHEMBL2169920)
Affinity DataIC50:  120nMAssay Description:Inhibition of full length human SMYD2 amino acid 1 to 433 expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl- GSRAHSSHLKSKKGQSTSRH as...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396027(CHEMBL499593)
Affinity DataIC50:  170nMAssay Description:Inhibition of G9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396020(CHEMBL1615036)
Affinity DataIC50:  180nMAssay Description:Inhibition of JMJD2E catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50185388(CHEMBL378900 | N-(3,3-diphenylpropyl)-1-3-[3-({7-[...)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length N-terminal 6x His-tagged human LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate by luminold...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396013(CHEMBL1198896)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length N-terminal 6x His-tagged human LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate by luminold...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50361470(CHEMBL226102)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length N-terminal 6x His-tagged human LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate by luminold...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396021(CHEMBL1196431)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length N-terminal 6x His-tagged human LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate by luminold...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396026(CHEMBL2172426)
Affinity DataIC50:  530nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  530nMAssay Description:Inhibition of G9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase Su(var)3-9(Drosophila melanogaster)
TBA

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant Drosophila melanogaster SUV39 by radioactive filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396026(CHEMBL2172426)
Affinity DataIC50:  630nMAssay Description:Inhibition of G9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50300028(CHEMBL569864 | N-(1-benzylpiperidin-4-yl)-6,7-dime...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human N-terminal hexahistidine-tagged GLP SET domain amino acid 951 to 1235 expressed in Escherichia coli BL21 (DE3) using Histone H3 p...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  800nMAssay Description:Inhibition of human SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396014(CHEMBL2169888)
Affinity DataIC50:  990nMAssay Description:Inhibition of LSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396024(CHEMBL1232453)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant G9a catalytic domain amino acid 913 to 1193 expressed in Escherichia coli BL21 (DE3) by mass spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396029(CHEMBL1222849)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of GST-tagged G9a after 1 hr by radioactive filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of JMJD2A catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50300028(CHEMBL569864 | N-(1-benzylpiperidin-4-yl)-6,7-dime...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human N-terminal hexahistidine-tagged G9a SET domain amino acid 913 to 1193 expressed in Escherichia coli BL21 (DE3) using Histone H3 p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50346862(CHEMBL1215658)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of N terminal hexahistidine-tag recombinant human LSD1 expressed in Escherichia coli BL21 (DE3) using histone H3 peptide as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of GST-tagged G9a after 1 hr by radioactive filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of JMJD2E catalytic domain by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50361472(CHEMBL1938896)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human JMJD2EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of mouse G9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50346534(CHEMBL1797705)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of N terminal hexahistidine-tag recombinant human LSD1 expressed in Escherichia coli BL21 (DE3) using histone H3 peptide as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50361475(CHEMBL1938900)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of N-terminal GST-fused human JMJD2C catalytic domain amino acid 1 to 420 using H3K9me3 as substrate by mass spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50361475(CHEMBL1938900)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of JMJD2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50361475(CHEMBL1938900)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396025(CHEMBL1089088)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396025(CHEMBL1089088)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of G9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50396028(CHEMBL1222848)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of GST-tagged G9a after 1 hr by radioactive filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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