Compile Data Set for Download or QSAR
Found 21 Enz. Inhib. hit(s) with all data for entry = 10107
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514126(US11052091, Example 5-1)
Show SMILES CS(=O)(=O)c1ccc(Nc2nc(N)c3n(-c4cccc5[nH]ncc45)c(=O)n(C4CCCC4)c3n2)c(F)c1
Show InChI InChI=1S/C24H23FN8O3S/c1-37(35,36)14-9-10-18(16(25)11-14)28-23-29-21(26)20-22(30-23)32(13-5-2-3-6-13)24(34)33(20)19-8-4-7-17-15(19)12-27-31-17/h4,7-13H,2-3,5-6H2,1H3,(H,27,31)(H3,26,28,29,30)
Affinity DataIC50: 2nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514134(US11052091, Example 5-16)
Show SMILES Nc1nc(Nc2ccc(cc2F)C(=O)N2CCNCC2)nc2n(C3CCC(F)(F)C3)c(=O)n(-c3ccc(Cl)c(O)c3)c12
Show InChI InChI=1S/C27H26ClF3N8O3/c28-17-3-2-15(12-20(17)40)38-21-22(32)35-25(36-23(21)39(26(38)42)16-5-6-27(30,31)13-16)34-19-4-1-14(11-18(19)29)24(41)37-9-7-33-8-10-37/h1-4,11-12,16,33,40H,5-10,13H2,(H3,32,34,35,36)
Affinity DataIC50: 2nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514135(US11052091, Example 5-17)
Show SMILES CC(C)n1c2nc(Nc3ccc4C(=O)N(C)Cc4c3)nc(N)c2n(-c2ccc3[nH]ccc3c2)c1=O
Show InChI InChI=1S/C25H24N8O2/c1-13(2)32-22-20(33(25(32)35)17-5-7-19-14(11-17)8-9-27-19)21(26)29-24(30-22)28-16-4-6-18-15(10-16)12-31(3)23(18)34/h4-11,13,27H,12H2,1-3H3,(H3,26,28,29,30)
Affinity DataIC50: 3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514136(US11052091, Example 5-18)
Show SMILES CC(C)n1c2nc(Nc3cn(C)nc3C)nc(N)c2n(-c2ccc3cc[nH]c3c2)c1=O
Show InChI InChI=1S/C21H23N9O/c1-11(2)29-19-17(18(22)25-20(26-19)24-16-10-28(4)27-12(16)3)30(21(29)31)14-6-5-13-7-8-23-15(13)9-14/h5-11,23H,1-4H3,(H3,22,24,25,26)
Affinity DataIC50: 3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514137(US11052091, Example 5-19)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)C(=O)N(C)C)nc(N)c2n(-c2ccc3[nH]ccc3c2)c1=O
Show InChI InChI=1S/C25H25FN8O2/c1-13(2)33-22-20(34(25(33)36)16-6-8-18-14(11-16)9-10-28-18)21(27)30-24(31-22)29-19-7-5-15(12-17(19)26)23(35)32(3)4/h5-13,28H,1-4H3,(H3,27,29,30,31)
Affinity DataIC50: 3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514124(US11052091, Example 3)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(F)c3[nH]ncc23)c1=O
Show InChI InChI=1S/C22H20F2N8O3S/c1-10(2)31-20-18(32(22(31)33)16-7-5-13(23)17-12(16)9-26-30-17)19(25)28-21(29-20)27-15-6-4-11(8-14(15)24)36(3,34)35/h4-10H,1-3H3,(H,26,30)(H3,25,27,28,29)
Affinity DataIC50: 5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514138(US11052091, Example 5-21)
Show SMILES COc1cc(Nc2nc(N)c3n(-c4ccc5[nH]ccc5c4)c(=O)n(C(C)C)c3n2)ccc1C(=O)N(C)C
Show InChI InChI=1S/C26H28N8O3/c1-14(2)33-23-21(34(26(33)36)17-7-9-19-15(12-17)10-11-28-19)22(27)30-25(31-23)29-16-6-8-18(20(13-16)37-5)24(35)32(3)4/h6-14,28H,1-5H3,(H3,27,29,30,31)
Affinity DataIC50: 5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514127(US11052091, Example 5-2)
Show SMILES CS(=O)(=O)c1ccc(Nc2nc(N)c3n(-c4cccc5[nH]ncc45)c(=O)n(C4CCC4)c3n2)c(F)c1
Show InChI InChI=1S/C23H21FN8O3S/c1-36(34,35)13-8-9-17(15(24)10-13)27-22-28-20(25)19-21(29-22)31(12-4-2-5-12)23(33)32(19)18-7-3-6-16-14(18)11-26-30-16/h3,6-12H,2,4-5H2,1H3,(H,26,30)(H3,25,27,28,29)
Affinity DataIC50: 5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514129(US11052091, Example 5-4)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(C)c3[nH]ncc23)c1=O
Show InChI InChI=1S/C23H23FN8O3S/c1-11(2)31-21-19(32(23(31)33)17-8-5-12(3)18-14(17)10-26-30-18)20(25)28-22(29-21)27-16-7-6-13(9-15(16)24)36(4,34)35/h5-11H,1-4H3,(H,26,30)(H3,25,27,28,29)
Affinity DataIC50: 6nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514128(US11052091, Example 5-3)
Show SMILES CC(C)(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2cccc3[nH]ncc23)c1=O
Show InChI InChI=1S/C23H23FN8O3S/c1-23(2,3)32-20-18(31(22(32)33)17-7-5-6-15-13(17)11-26-30-15)19(25)28-21(29-20)27-16-9-8-12(10-14(16)24)36(4,34)35/h5-11H,1-4H3,(H,26,30)(H3,25,27,28,29)
Affinity DataIC50: 6nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514130(US11052091, Example 5-5)
Show SMILES CS(=O)(=O)c1ccc(Nc2nc(N)c3n(-c4cccc5[nH]ncc45)c(=O)n(C4CCC(F)(F)C4)c3n2)c(F)c1
Affinity DataIC50: 7nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514121(US11052091, Example 1)
Show SMILES CC(C)(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(F)c3[nH]ncc23)c1=O
Show InChI InChI=1S/C23H22F2N8O3S/c1-23(2,3)33-20-18(32(22(33)34)16-8-6-13(24)17-12(16)10-27-31-17)19(26)29-21(30-20)28-15-7-5-11(9-14(15)25)37(4,35)36/h5-10H,1-4H3,(H,27,31)(H3,26,28,29,30)
Affinity DataIC50: 7nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514139(US11052091, Example 5-22)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)C(=O)NCCN(C)C)nc(N)c2n(-c2ccc(Cl)c(O)c2)c1=O
Show InChI InChI=1S/C25H28ClFN8O3/c1-13(2)34-22-20(35(25(34)38)15-6-7-16(26)19(36)12-15)21(28)31-24(32-22)30-18-8-5-14(11-17(18)27)23(37)29-9-10-33(3)4/h5-8,11-13,36H,9-10H2,1-4H3,(H,29,37)(H3,28,30,31,32)
Affinity DataIC50: 7nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514131(US11052091, Example 5-8)
Show SMILES COc1cc(ccc1Nc1nc(N)c2n(-c3ccc4cn[nH]c4c3)c(=O)n(C3CCOC3)c2n1)S(C)(=O)=O
Affinity DataIC50: 9nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514122(US11052091, Example 2-1)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(Cl)c3[nH]ncc23)c1=O
Show InChI InChI=1S/C22H20ClFN8O3S/c1-10(2)31-20-18(32(22(31)33)16-7-5-13(23)17-12(16)9-26-30-17)19(25)28-21(29-20)27-15-6-4-11(8-14(15)24)36(3,34)35/h4-10H,1-3H3,(H,26,30)(H3,25,27,28,29)
Affinity DataIC50: 9nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514123(US11052091, Example 2-2)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2cc(F)c(F)c3[nH]ncc23)c1=O
Show InChI InChI=1S/C22H19F3N8O3S/c1-9(2)32-20-18(33(22(32)34)15-7-13(24)16(25)17-11(15)8-27-31-17)19(26)29-21(30-20)28-14-5-4-10(6-12(14)23)37(3,35)36/h4-9H,1-3H3,(H,27,31)(H3,26,28,29,30)
Affinity DataIC50: 10nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514125(US11052091, Example 4)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)C(C)=O)nc(N)c2n(-c2cccc3[nH]ncc23)c1=O
Show InChI InChI=1S/C23H21FN8O2/c1-11(2)31-21-19(32(23(31)34)18-6-4-5-16-14(18)10-26-30-16)20(25)28-22(29-21)27-17-8-7-13(12(3)33)9-15(17)24/h4-11H,1-3H3,(H,26,30)(H3,25,27,28,29)
Affinity DataIC50: 11nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514140(US11052091, Example 5-27)
Show SMILES CC(C)n1c2nc(Nc3ccc(cc3F)C(=O)N3C=CC(O)C=C3)nc(N)c2n(-c2ccc(Cl)c(O)c2)c1=O
Show InChI InChI=1S/C26H23ClFN7O4/c1-13(2)34-23-21(35(26(34)39)15-4-5-17(27)20(37)12-15)22(29)31-25(32-23)30-19-6-3-14(11-18(19)28)24(38)33-9-7-16(36)8-10-33/h3-13,16,36-37H,1-2H3,(H3,29,30,31,32)
Affinity DataIC50: 14nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514132(US11052091, Example 5-10)
Show SMILES CC(C)n1c2nc(Nc3ccc(c(F)c3F)S(C)(=O)=O)nc(N)c2n(-c2ccc3cn[nH]c3c2F)c1=O
Show InChI InChI=1S/C22H19F3N8O3S/c1-9(2)32-20-18(33(22(32)34)12-6-4-10-8-27-31-17(10)15(12)24)19(26)29-21(30-20)28-11-5-7-13(37(3,35)36)16(25)14(11)23/h4-9H,1-3H3,(H,27,31)(H3,26,28,29,30)
Affinity DataIC50: 21nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514133(US11052091, Example 5-11)
Show SMILES CC(C)n1c2nc(Nc3ccc(c(F)c3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(F)c3[nH]ncc23)c1=O
Show InChI InChI=1S/C22H19F3N8O3S/c1-9(2)32-20-18(33(22(32)34)13-6-4-11(23)17-10(13)8-27-31-17)19(26)29-21(30-20)28-12-5-7-14(37(3,35)36)16(25)15(12)24/h4-9H,1-3H3,(H,27,31)(H3,26,28,29,30)
Affinity DataIC50: 22nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
ONO PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM514141(US11052091, Example 5-32)
Show SMILES Nc1nc(Nc2ccc(cc2F)S(N)(=O)=O)nc2n(C3CCOC3)c(=O)n(-c3ccc4[nH]ccc4c3)c12
Affinity DataIC50: 54nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid