Compile Data Set for Download or QSAR
Found 334 Enz. Inhib. hit(s) with all data for entry = 10108
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172085(US10155002, Compound 91 | US11052093, Compound 91 ...)
Show SMILES CCNCc1ccc(cc1)-c1cc(N(CC)C2CCOCC2)c(C)c(c1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C32H42N4O3/c1-6-33-19-24-8-10-25(11-9-24)26-17-28(31(37)34-20-29-21(3)16-22(4)35-32(29)38)23(5)30(18-26)36(7-2)27-12-14-39-15-13-27/h8-11,16-18,27,33H,6-7,12-15,19-20H2,1-5H3,(H,34,37)(H,35,38)
Affinity DataIC50: 0.520nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172163(US10155002, Compound 171 | US11052093, Compound 17...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C33H44N6O3/c1-6-39(27-9-15-42-16-10-27)30-19-26(25-7-8-31(34-20-25)38-13-11-37(5)12-14-38)18-28(24(30)4)32(40)35-21-29-22(2)17-23(3)36-33(29)41/h7-8,17-20,27H,6,9-16,21H2,1-5H3,(H,35,40)(H,36,41)
Affinity DataIC50: 0.760nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172087(US10155002, Compound 93 | US11052093, Compound 93 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNCC2CC2)cc1
Show InChI InChI=1S/C34H44N4O3/c1-5-38(29-12-14-41-15-13-29)32-18-28(27-10-8-26(9-11-27)20-35-19-25-6-7-25)17-30(24(32)4)33(39)36-21-31-22(2)16-23(3)37-34(31)40/h8-11,16-18,25,29,35H,5-7,12-15,19-21H2,1-4H3,(H,36,39)(H,37,40)
Affinity DataIC50: 0.870nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172176(EPZ009161 | US10155002, Compound 184 | US11052093,...)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C34H46N6O3/c1-5-7-25-18-23(3)38-34(42)30(25)22-37-33(41)29-19-27(26-8-9-32(36-21-26)39-14-12-35-13-15-39)20-31(24(29)4)40(6-2)28-10-16-43-17-11-28/h8-9,18-21,28,35H,5-7,10-17,22H2,1-4H3,(H,37,41)(H,38,42)
Affinity DataIC50: 0.920nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172080(US10155002, Compound 86 | US11052093, Compound 86 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCCNCC2)cc1
Show InChI InChI=1S/C35H47N5O3/c1-5-40(30-11-17-43-18-12-30)33-21-29(28-9-7-27(8-10-28)23-39-15-6-13-36-14-16-39)20-31(26(33)4)34(41)37-22-32-24(2)19-25(3)38-35(32)42/h7-10,19-21,30,36H,5-6,11-18,22-23H2,1-4H3,(H,37,41)(H,38,42)
Affinity DataIC50: 1.12nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172138(EPZ007428 | US10155002, Compound 145 | US11052093,...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnn(C)c1
Affinity DataIC50: 1.39nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172135(EPZ007210 | US10155002, Compound 141 | US11052093,...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)nc2=O)c1C)-c1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 1.51nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172089(US10155002, Compound 95 | US11052093, Compound 95 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNC[C@@H](O)CO)cc1
Affinity DataIC50: 1.55nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172162(US10155002, Compound 170 | US11052093, Compound 17...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1
Affinity DataIC50: 1.63nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172181(US10155002, Compound 189 | US11052093, Compound 18...)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(nc1)N1CCN(CC1)C1CCN(C)CC1
Show InChI InChI=1S/C40H57N7O3/c1-6-8-30-23-28(3)43-40(49)36(30)27-42-39(48)35-24-32(25-37(29(35)4)47(7-2)34-13-21-50-22-14-34)31-9-10-38(41-26-31)46-19-17-45(18-20-46)33-11-15-44(5)16-12-33/h9-10,23-26,33-34H,6-8,11-22,27H2,1-5H3,(H,42,48)(H,43,49)
Affinity DataIC50: 1.64nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172181(US10155002, Compound 189 | US11052093, Compound 18...)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(nc1)N1CCN(CC1)C1CCN(C)CC1
Show InChI InChI=1S/C40H57N7O3/c1-6-8-30-23-28(3)43-40(49)36(30)27-42-39(48)35-24-32(25-37(29(35)4)47(7-2)34-13-21-50-22-14-34)31-9-10-38(41-26-31)46-19-17-45(18-20-46)33-11-15-44(5)16-12-33/h9-10,23-26,33-34H,6-8,11-22,27H2,1-5H3,(H,42,48)(H,43,49)
Affinity DataIC50: 1.82nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172135(EPZ007210 | US10155002, Compound 141 | US11052093,...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)nc2=O)c1C)-c1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 1.95nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172084(US10155002, Compound 90 | US11052093, Compound 90 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNC)cc1
Show InChI InChI=1S/C31H40N4O3/c1-6-35(26-11-13-38-14-12-26)29-17-25(24-9-7-23(8-10-24)18-32-5)16-27(22(29)4)30(36)33-19-28-20(2)15-21(3)34-31(28)37/h7-10,15-17,26,32H,6,11-14,18-19H2,1-5H3,(H,33,36)(H,34,37)
Affinity DataIC50: 1.99nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172088(US10155002, Compound 94 | US11052093, Compound 94 ...)
Show SMILES CCN(CC)Cc1ccc(cc1)-c1cc(N(CC)C2CCOCC2)c(C)c(c1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C34H46N4O3/c1-7-37(8-2)22-26-10-12-27(13-11-26)28-19-30(33(39)35-21-31-23(4)18-24(5)36-34(31)40)25(6)32(20-28)38(9-3)29-14-16-41-17-15-29/h10-13,18-20,29H,7-9,14-17,21-22H2,1-6H3,(H,35,39)(H,36,40)
Affinity DataIC50: 2.07nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172065(US10155002, Compound 71 | US11052093, Compound 71 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CC[C@@H](O)C2)cc1
Affinity DataIC50: 2.19nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172173(US10155002, Compound 181 | US11052093, Compound 18...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(cc1)C(=O)N1CCC1
Affinity DataIC50: 2.23nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172093(US10155002, Compound 99 | US11052093, Compound 99 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNCCCO)cc1
Show InChI InChI=1S/C33H44N4O4/c1-5-37(28-11-15-41-16-12-28)31-19-27(26-9-7-25(8-10-26)20-34-13-6-14-38)18-29(24(31)4)32(39)35-21-30-22(2)17-23(3)36-33(30)40/h7-10,17-19,28,34,38H,5-6,11-16,20-21H2,1-4H3,(H,35,39)(H,36,40)
Affinity DataIC50: 2.37nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172088(US10155002, Compound 94 | US11052093, Compound 94 ...)
Show SMILES CCN(CC)Cc1ccc(cc1)-c1cc(N(CC)C2CCOCC2)c(C)c(c1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C34H46N4O3/c1-7-37(8-2)22-26-10-12-27(13-11-26)28-19-30(33(39)35-21-31-23(4)18-24(5)36-34(31)40)25(6)32(20-28)38(9-3)29-14-16-41-17-15-29/h10-13,18-20,29H,7-9,14-17,21-22H2,1-6H3,(H,35,39)(H,36,40)
Affinity DataIC50: 2.46nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172093(US10155002, Compound 99 | US11052093, Compound 99 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNCCCO)cc1
Show InChI InChI=1S/C33H44N4O4/c1-5-37(28-11-15-41-16-12-28)31-19-27(26-9-7-25(8-10-26)20-34-13-6-14-38)18-29(24(31)4)32(39)35-21-30-22(2)17-23(3)36-33(30)40/h7-10,17-19,28,34,38H,5-6,11-16,20-21H2,1-4H3,(H,35,39)(H,36,40)
Affinity DataIC50: 2.56nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172087(US10155002, Compound 93 | US11052093, Compound 93 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNCC2CC2)cc1
Show InChI InChI=1S/C34H44N4O3/c1-5-38(29-12-14-41-15-13-29)32-18-28(27-10-8-26(9-11-27)20-35-19-25-6-7-25)17-30(24(32)4)33(39)36-21-31-22(2)16-23(3)37-34(31)40/h8-11,16-18,25,29,35H,5-7,12-15,19-21H2,1-4H3,(H,36,39)(H,37,40)
Affinity DataIC50: 2.58nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172063(US10155002, Compound 69 | US11052093, Compound 69 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCCC2)cc1
Show InChI InChI=1S/C34H44N4O3/c1-5-38(29-12-16-41-17-13-29)32-20-28(27-10-8-26(9-11-27)22-37-14-6-7-15-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h8-11,18-20,29H,5-7,12-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
Affinity DataIC50: 2.60nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172161(US10155002, Compound 169 | US11052093, Compound 16...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1nccn1C
Affinity DataIC50: 2.74nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172089(US10155002, Compound 95 | US11052093, Compound 95 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNC[C@@H](O)CO)cc1
Affinity DataIC50: 2.77nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172076(US10155002, Compound 82 | US11052093, Compound 82 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCC2)cc1
Show InChI InChI=1S/C33H42N4O3/c1-5-37(28-11-15-40-16-12-28)31-19-27(26-9-7-25(8-10-26)21-36-13-6-14-36)18-29(24(31)4)32(38)34-20-30-22(2)17-23(3)35-33(30)39/h7-10,17-19,28H,5-6,11-16,20-21H2,1-4H3,(H,34,38)(H,35,39)
Affinity DataIC50: 2.81nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172183(US10155002, Compound 191 | US11052093, Compound 19...)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(CN2CCOCC2)nc1
Show InChI InChI=1S/C35H47N5O4/c1-5-7-26-18-24(3)38-35(42)32(26)22-37-34(41)31-19-28(20-33(25(31)4)40(6-2)30-10-14-43-15-11-30)27-8-9-29(36-21-27)23-39-12-16-44-17-13-39/h8-9,18-21,30H,5-7,10-17,22-23H2,1-4H3,(H,37,41)(H,38,42)
Affinity DataIC50: 2.82nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnccn1
Affinity DataIC50: 2.89nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172091(US10155002, Compound 97 | US11052093, Compound 97 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN(C)CC2CC2)cc1
Show InChI InChI=1S/C35H46N4O3/c1-6-39(30-13-15-42-16-14-30)33-19-29(28-11-9-27(10-12-28)22-38(5)21-26-7-8-26)18-31(25(33)4)34(40)36-20-32-23(2)17-24(3)37-35(32)41/h9-12,17-19,26,30H,6-8,13-16,20-22H2,1-5H3,(H,36,40)(H,37,41)
Affinity DataIC50: 2.96nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172074(US10155002, Compound 80 | US11052093, Compound 80 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCC(F)CC2)cc1
Show InChI InChI=1S/C35H45FN4O3/c1-5-40(30-12-16-43-17-13-30)33-20-28(27-8-6-26(7-9-27)22-39-14-10-29(36)11-15-39)19-31(25(33)4)34(41)37-21-32-23(2)18-24(3)38-35(32)42/h6-9,18-20,29-30H,5,10-17,21-22H2,1-4H3,(H,37,41)(H,38,42)
Affinity DataIC50: 3.11nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172085(US10155002, Compound 91 | US11052093, Compound 91 ...)
Show SMILES CCNCc1ccc(cc1)-c1cc(N(CC)C2CCOCC2)c(C)c(c1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C32H42N4O3/c1-6-33-19-24-8-10-25(11-9-24)26-17-28(31(37)34-20-29-21(3)16-22(4)35-32(29)38)23(5)30(18-26)36(7-2)27-12-14-39-15-13-27/h8-11,16-18,27,33H,6-7,12-15,19-20H2,1-5H3,(H,34,37)(H,35,38)
Affinity DataIC50: 3.15nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
Affinity DataIC50: 3.19nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172184(US10155002, Compound 192 | US11052093, Compound 19...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C35H48N6O3/c1-7-41(29-12-16-44-17-13-29)32-20-27(26-8-9-33(36-21-26)40-14-10-28(11-15-40)39(5)6)19-30(25(32)4)34(42)37-22-31-23(2)18-24(3)38-35(31)43/h8-9,18-21,28-29H,7,10-17,22H2,1-6H3,(H,37,42)(H,38,43)
Affinity DataIC50: 3.22nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172072(US10155002, Compound 78 | US11052093, Compound 78 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCC(O)CC2)cc1
Show InChI InChI=1S/C35H46N4O4/c1-5-39(29-12-16-43-17-13-29)33-20-28(27-8-6-26(7-9-27)22-38-14-10-30(40)11-15-38)19-31(25(33)4)34(41)36-21-32-23(2)18-24(3)37-35(32)42/h6-9,18-20,29-30,40H,5,10-17,21-22H2,1-4H3,(H,36,41)(H,37,42)
Affinity DataIC50: 3.24nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172177(US10155002, Compound 185 | US11052093, Compound 18...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(cc(C)[nH]c2=O)C(C)C)c1C)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C34H46N6O3/c1-6-40(27-9-15-43-16-10-27)31-19-26(25-7-8-32(36-20-25)39-13-11-35-12-14-39)18-29(24(31)5)33(41)37-21-30-28(22(2)3)17-23(4)38-34(30)42/h7-8,17-20,22,27,35H,6,9-16,21H2,1-5H3,(H,37,41)(H,38,42)
Affinity DataIC50: 3.38nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172091(US10155002, Compound 97 | US11052093, Compound 97 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN(C)CC2CC2)cc1
Show InChI InChI=1S/C35H46N4O3/c1-6-39(30-13-15-42-16-14-30)33-19-29(28-11-9-27(10-12-28)22-38(5)21-26-7-8-26)18-31(25(33)4)34(40)36-20-32-23(2)17-24(3)37-35(32)41/h9-12,17-19,26,30H,6-8,13-16,20-22H2,1-5H3,(H,36,40)(H,37,41)
Affinity DataIC50: 3.40nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172140(US10155002, Compound 147 | US11052093, Compound 14...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccccc1
Affinity DataIC50: 3.44nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172069(US10155002, Compound 75 | US11052093, Compound 75 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCCCC2)cc1
Show InChI InChI=1S/C35H46N4O3/c1-5-39(30-13-17-42-18-14-30)33-21-29(28-11-9-27(10-12-28)23-38-15-7-6-8-16-38)20-31(26(33)4)34(40)36-22-32-24(2)19-25(3)37-35(32)41/h9-12,19-21,30H,5-8,13-18,22-23H2,1-4H3,(H,36,40)(H,37,41)
Affinity DataIC50: 3.48nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172063(US10155002, Compound 69 | US11052093, Compound 69 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCCC2)cc1
Show InChI InChI=1S/C34H44N4O3/c1-5-38(29-12-16-41-17-13-29)32-20-28(27-10-8-26(9-11-27)22-37-14-6-7-15-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h8-11,18-20,29H,5-7,12-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
Affinity DataIC50: 3.49nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172076(US10155002, Compound 82 | US11052093, Compound 82 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCC2)cc1
Show InChI InChI=1S/C33H42N4O3/c1-5-37(28-11-15-40-16-12-28)31-19-27(26-9-7-25(8-10-26)21-36-13-6-14-36)18-29(24(31)4)32(38)34-20-30-22(2)17-23(3)35-33(30)39/h7-10,17-19,28H,5-6,11-16,20-21H2,1-4H3,(H,34,38)(H,35,39)
Affinity DataIC50: 3.52nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172149(US10155002, Compound 156 | US11052093, Compound 15...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccsc1
Affinity DataIC50: 3.57nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172084(US10155002, Compound 90 | US11052093, Compound 90 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNC)cc1
Show InChI InChI=1S/C31H40N4O3/c1-6-35(26-11-13-38-14-12-26)29-17-25(24-9-7-23(8-10-24)18-32-5)16-27(22(29)4)30(36)33-19-28-20(2)15-21(3)34-31(28)37/h7-10,15-17,26,32H,6,11-14,18-19H2,1-5H3,(H,33,36)(H,34,37)
Affinity DataIC50: 3.61nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172134(US10155002, Compound 140 | US11052093, Compound 14...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)nc2=O)c1C)-c1ccc(CN2CCOCC2)c(c1)C#N
Show InChI InChI=1S/C35H42N5O4/c1-5-40(30-8-12-43-13-9-30)33-19-28(26-6-7-27(29(17-26)20-36)22-39-10-14-44-15-11-39)18-31(25(33)4)34(41)37-21-32-23(2)16-24(3)38-35(32)42/h6-7,16-19,30H,5,8-15,21-22H2,1-4H3,(H,37,41)
Affinity DataIC50: 3.69nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172070(US10155002, Compound 76 | US11052093, Compound 76 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCC[C@H](O)C2)cc1
Affinity DataIC50: 3.74nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172177(US10155002, Compound 185 | US11052093, Compound 18...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(cc(C)[nH]c2=O)C(C)C)c1C)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C34H46N6O3/c1-6-40(27-9-15-43-16-10-27)31-19-26(25-7-8-32(36-20-25)39-13-11-35-12-14-39)18-29(24(31)5)33(41)37-21-30-28(22(2)3)17-23(4)38-34(30)42/h7-8,17-20,22,27,35H,6,9-16,21H2,1-5H3,(H,37,41)(H,38,42)
Affinity DataIC50: 3.74nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172183(US10155002, Compound 191 | US11052093, Compound 19...)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(CN2CCOCC2)nc1
Show InChI InChI=1S/C35H47N5O4/c1-5-7-26-18-24(3)38-35(42)32(26)22-37-34(41)31-19-28(20-33(25(31)4)40(6-2)30-10-14-43-15-11-30)27-8-9-29(36-21-27)23-39-12-16-44-17-13-39/h8-9,18-21,30H,5-7,10-17,22-23H2,1-4H3,(H,37,41)(H,38,42)
Affinity DataIC50: 3.84nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172175(EPZ009097 | US10155002, Compound 183 | US11052093,...)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C35H48N6O3/c1-6-8-26-19-24(3)38-35(43)31(26)23-37-34(42)30-20-28(21-32(25(30)4)41(7-2)29-11-17-44-18-12-29)27-9-10-33(36-22-27)40-15-13-39(5)14-16-40/h9-10,19-22,29H,6-8,11-18,23H2,1-5H3,(H,37,42)(H,38,43)
Affinity DataIC50: 3.87nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172074(US10155002, Compound 80 | US11052093, Compound 80 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCC(F)CC2)cc1
Show InChI InChI=1S/C35H45FN4O3/c1-5-40(30-12-16-43-17-13-30)33-20-28(27-8-6-26(7-9-27)22-39-14-10-29(36)11-15-39)19-31(25(33)4)34(41)37-21-32-23(2)18-24(3)38-35(32)42/h6-9,18-20,29-30H,5,10-17,21-22H2,1-4H3,(H,37,41)(H,38,42)
Affinity DataIC50: 3.88nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172163(US10155002, Compound 171 | US11052093, Compound 17...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1
Show InChI InChI=1S/C33H44N6O3/c1-6-39(27-9-15-42-16-10-27)30-19-26(25-7-8-31(34-20-25)38-13-11-37(5)12-14-38)18-28(24(30)4)32(40)35-21-29-22(2)17-23(3)36-33(29)41/h7-8,17-20,27H,6,9-16,21H2,1-5H3,(H,35,40)(H,36,41)
Affinity DataIC50: 3.97nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172065(US10155002, Compound 71 | US11052093, Compound 71 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CC[C@@H](O)C2)cc1
Affinity DataIC50: 4.15nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172077(US10155002, Compound 83 | US11052093, Compound 83 ...)
Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CC(O)C2)cc1
Show InChI InChI=1S/C33H42N4O4/c1-5-37(27-10-12-41-13-11-27)31-16-26(25-8-6-24(7-9-25)18-36-19-28(38)20-36)15-29(23(31)4)32(39)34-17-30-21(2)14-22(3)35-33(30)40/h6-9,14-16,27-28,38H,5,10-13,17-20H2,1-4H3,(H,34,39)(H,35,40)
Affinity DataIC50: 4.18nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172164(US10155002, Compound 172 | US11052093, Compound 17...)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCNCC1
Affinity DataIC50: 4.21nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
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