Compile Data Set for Download or QSAR
Found 117 Enz. Inhib. hit(s) with all data for entry = 10111
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404343(US10343992, Example 2 | US10689345, Example 2 | US...)
Show SMILES COc1cc(ccc1-c1cnn(C)c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H19N5O2/c1-21-9-13(8-19-21)15-4-3-12(7-16(15)24-2)17(23)20-14-5-6-22(10-14)11-18/h3-4,7-9,14H,5-6,10H2,1-2H3,(H,20,23)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404589((3aR,6aR)-5-cyano-N-(3-(2-methylpyridin-4-yl)pheny...)
Show SMILES Cc1cc(ccn1)-c1cccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)c1
Show InChI InChI=1S/C20H21N5O/c1-14-9-16(5-7-22-14)15-3-2-4-18(10-15)23-20(26)25-8-6-17-11-24(13-21)12-19(17)25/h2-5,7,9-10,17,19H,6,8,11-12H2,1H3,(H,23,26)/t17-,19+/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514218(3-(3-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)isox...)
Show SMILES Clc1cccc(c1)-c1noc(n1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C14H12ClN5O2/c15-10-3-1-2-9(6-10)12-18-14(22-19-12)13(21)17-11-4-5-20(7-11)8-16/h1-3,6,11H,4-5,7H2,(H,17,21)/t11-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514223(3'-chloro-N-(1-cyanopyrrolidin-3- yl)-[1,1'-biphen...)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H16ClN3O/c19-16-3-1-2-15(10-16)13-4-6-14(7-5-13)18(23)21-17-8-9-22(11-17)12-20/h1-7,10,17H,8-9,11H2,(H,21,23)/t17-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514225(N-(1-cyanopyrrolidin-3-yl)-2'- methoxy-[1,1'-biphe...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19N3O2/c1-24-18-5-3-2-4-17(18)14-6-8-15(9-7-14)19(23)21-16-10-11-22(12-16)13-20/h2-9,16H,10-12H2,1H3,(H,21,23)/t16-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404438((3aR,6aR)-5-cyano-N-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N)C(F)(F)F
Show InChI InChI=1S/C15H14F4N4O/c16-11-5-10(15(17,18)19)1-2-12(11)21-14(24)23-4-3-9-6-22(8-20)7-13(9)23/h1-2,5,9,13H,3-4,6-7H2,(H,21,24)/t9-,13+/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514242((R)—N-(1-cyanopyrrolidin-3-yl)-2-fluoro-4-(py...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1ccc(Nc2ncccn2)cc1F
Show InChI InChI=1S/C20H24FN5O3/c1-20(2,3)29-19(28)26-10-7-14(12-26)24-17(27)15-6-5-13(11-16(15)21)25-18-22-8-4-9-23-18/h4-6,8-9,11,14H,7,10,12H2,1-3H3,(H,24,27)(H,22,23,25)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404441(2-(2-chlorophenyl)-N-((trans)-1-cyano-4-hydroxypyr...)
Show SMILES O[C@H]1CN(C[C@@H]1NC(=O)c1cnc(s1)-c1ccccc1Cl)C#N
Show InChI InChI=1S/C15H13ClN4O2S/c16-10-4-2-1-3-9(10)15-18-5-13(23-15)14(22)19-11-6-20(8-17)7-12(11)21/h1-5,11-12,21H,6-7H2,(H,19,22)/t11-,12-/m0/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404502((R)-N-(1-cyanopyrrolidin-3-yl)-6-(3, 5-dimethyliso...)
Show SMILES CC(C)Cn1nc(C(=O)N[C@@H]2CCN(C2)C#N)c2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H26N6O2/c1-13(2)10-28-19-9-16(20-14(3)26-30-15(20)4)5-6-18(19)21(25-28)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,13,17H,7-8,10-11H2,1-4H3,(H,24,29)/t17-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404503((R)-N-(1-cyanopyrrolidin-3-yl)-1-(cyclopropylmethy...)
Show SMILES Cc1noc(C)c1-c1ccc2c(nn(CC3CC3)c2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C22H24N6O2/c1-13-20(14(2)30-26-13)16-5-6-18-19(9-16)28(10-15-3-4-15)25-21(18)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,15,17H,3-4,7-8,10-11H2,1-2H3,(H,24,29)/t17-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404505((R)-N-(1-cyanopyrrolidin-3-yl)-N-methyl-5-(1-methy...)
Show SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1cc2cc(ccc2[nH]1)-c1cnn(C)c1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404508((R)-7-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)im...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1cnc2cc(ccn12)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N6O/c21-10-14-2-1-3-15(8-14)16-4-7-26-18(11-23-19(26)9-16)20(27)24-17-5-6-25(12-17)13-22/h1-4,7-9,11,17H,5-6,12H2,(H,24,27)/t17-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404515((R)-6-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)-3...)
Show SMILES Fc1c(nc2ccc(cn12)-c1cccc(c1)C#N)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C20H15FN6O/c21-19-18(20(28)24-16-6-7-26(11-16)12-23)25-17-5-4-15(10-27(17)19)14-3-1-2-13(8-14)9-22/h1-5,8,10,16H,6-7,11H2,(H,24,28)/t16-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404520((R)-N-(1-cyanopyrrolidin-3-yl)-2-fluoro-4-(pyrazol...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1ccn2nccc2n1
Show InChI InChI=1S/C18H15FN6O/c19-15-9-12(16-5-8-25-17(23-16)3-6-21-25)1-2-14(15)18(26)22-13-4-7-24(10-13)11-20/h1-3,5-6,8-9,13H,4,7,10H2,(H,22,26)/t13-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM447634((R)—N-(1-cyanopyrrolidin-3-yl)-5-(4-fluorophe...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1ccc(Br)cn1
Show InChI InChI=1S/C15H20BrN3O3/c1-15(2,3)22-14(21)19-7-6-11(9-19)18-13(20)12-5-4-10(16)8-17-12/h4-5,8,11H,6-7,9H2,1-3H3,(H,18,20)/t11-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404523(3-chloro-N-((trans)-1-cyano-4-methylpyrrolidin-3-y...)
Show SMILES C[C@H]1CN(C[C@@H]1NC(=O)c1ccc(N2CCOCC2)c(Cl)c1)C#N
Show InChI InChI=1S/C17H21ClN4O2/c1-12-9-21(11-19)10-15(12)20-17(23)13-2-3-16(14(18)8-13)22-4-6-24-7-5-22/h2-3,8,12,15H,4-7,9-10H2,1H3,(H,20,23)/t12-,15-/m0/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM505509((R)?N-(1-cyanopyrrolidin-3-yl)-4-(2,6-dimethylpyri...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1ccc(cc1F)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C22H32BFN2O5/c1-20(2,3)29-19(28)26-11-10-15(13-26)25-18(27)16-9-8-14(12-17(16)24)23-30-21(4,5)22(6,7)31-23/h8-9,12,15H,10-11,13H2,1-7H3,(H,25,27)/t15-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404538((R)-N-(1-cyanopyrrolidin-3-yl)-3-(4-methoxyphenyl)...)
Show SMILES COc1ccc(cc1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H20N4O2/c1-22-15-4-2-12(3-5-15)13-8-20(9-13)16(21)18-14-6-7-19(10-14)11-17/h2-5,13-14H,6-10H2,1H3,(H,18,21)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404539((R)-3-(4-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)a...)
Show SMILES Clc1ccc(cc1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H17ClN4O/c16-13-3-1-11(2-4-13)12-7-20(8-12)15(21)18-14-5-6-19(9-14)10-17/h1-4,12,14H,5-9H2,(H,18,21)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404540((R)-3-(3-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)a...)
Show SMILES Clc1cccc(c1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H17ClN4O/c16-13-3-1-2-11(6-13)12-7-20(8-12)15(21)18-14-4-5-19(9-14)10-17/h1-3,6,12,14H,4-5,7-9H2,(H,18,21)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404552((R)-1-(1-cyanopyrrolidin-3-yl)-1-ethyl-3-(4-(trifl...)
Show SMILES CCN([C@@H]1CCN(C1)C#N)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H17F3N4O/c1-2-22(13-7-8-21(9-13)10-19)14(23)20-12-5-3-11(4-6-12)15(16,17)18/h3-6,13H,2,7-9H2,1H3,(H,20,23)/t13-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404560((R)-N-(1-cyanopyrrolidin-3-yl)-4-(4-cyclopropylpyr...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc2N(CCOc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C21H22N6O2/c22-13-26-8-6-16(12-26)24-20(28)15-3-4-18-19(11-15)29-10-9-27(18)21-23-7-5-17(25-21)14-1-2-14/h3-5,7,11,14,16H,1-2,6,8-10,12H2,(H,24,28)/t16-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404561((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1cc(ccc1Nc1nccc(n1)C1CC1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19FN6O/c20-15-9-13(18(27)23-14-6-8-26(10-14)11-21)3-4-17(15)25-19-22-7-5-16(24-19)12-1-2-12/h3-5,7,9,12,14H,1-2,6,8,10H2,(H,23,27)(H,22,24,25)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404562((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1c(Nc2nccc(n2)C2CC2)ccc(C(=O)N[C@@H]2CCN(C2)C#N)c1F
Show InChI InChI=1S/C19H18F2N6O/c20-16-13(18(28)24-12-6-8-27(9-12)10-22)3-4-15(17(16)21)26-19-23-7-5-14(25-19)11-1-2-11/h3-5,7,11-12H,1-2,6,8-9H2,(H,24,28)(H,23,25,26)/t12-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM447679((R)-3-(4-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)i...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1cc(no1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H22ClN3O4/c1-19(2,3)26-18(25)23-9-8-14(11-23)21-17(24)16-10-15(22-27-16)12-4-6-13(20)7-5-12/h4-7,10,14H,8-9,11H2,1-3H3,(H,21,24)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404569((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Show SMILES COc1cccc(c1)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H16N4O3/c1-22-13-4-2-3-11(7-13)14-8-15(23-19-14)16(21)18-12-5-6-20(9-12)10-17/h2-4,7-8,12H,5-6,9H2,1H3,(H,18,21)/t12-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404571((R)-N-(1-cyanopyrrolidin-3-yl)-3-fluoro-4-(4-methy...)
Show SMILES Cc1cn(cn1)-c1ccc(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H16FN5O/c1-11-7-22(10-19-11)15-3-2-12(6-14(15)17)16(23)20-13-4-5-21(8-13)9-18/h2-3,6-7,10,13H,4-5,8H2,1H3,(H,20,23)/t13-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404568((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3, 4-dimethoxyph...)
Show SMILES COc1ccc(cc1OC)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H18N4O4/c1-23-14-4-3-11(7-15(14)24-2)13-8-16(25-20-13)17(22)19-12-5-6-21(9-12)10-18/h3-4,7-8,12H,5-6,9H2,1-2H3,(H,19,22)/t12-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404580((R)-N-(1-cyanopyrrolidin-3-yl)-3-fluoro-1-methyl-5...)
Show SMILES Cn1cc(cn1)-c1ccc2n(C)c(C(=O)N[C@@H]3CCN(C3)C#N)c(F)c2c1
Show InChI InChI=1S/C19H19FN6O/c1-24-9-13(8-22-24)12-3-4-16-15(7-12)17(20)18(25(16)2)19(27)23-14-5-6-26(10-14)11-21/h3-4,7-9,14H,5-6,10H2,1-2H3,(H,23,27)/t14-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404582((R)-N-(1-cyanopyrrolidin-3-yl)-3-(1-phenyl-1H-pyra...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)c1ccn(n1)-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c19-13-22-8-6-15(12-22)20-18(25)23-10-14(11-23)17-7-9-24(21-17)16-4-2-1-3-5-16/h1-5,7,9,14-15H,6,8,10-12H2,(H,20,25)/t15-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404585((R)-3-(2-(4-chlorophenyl)pyrimidin-4-yl)-N-(1-cyan...)
Show SMILES Clc1ccc(cc1)-c1nccc(n1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19ClN6O/c20-15-3-1-13(2-4-15)18-22-7-5-17(24-18)14-9-26(10-14)19(27)23-16-6-8-25(11-16)12-21/h1-5,7,14,16H,6,8-11H2,(H,23,27)/t16-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404586((R)-3-(benzyloxy)-N-(1-cyanopyrrolidin-3-yl)-3-phe...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)(OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c23-17-25-12-11-20(13-25)24-21(27)26-15-22(16-26,19-9-5-2-6-10-19)28-14-18-7-3-1-4-8-18/h1-10,20H,11-16H2,(H,24,27)/t20-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404587((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc2N(CCc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C21H22N6O/c22-13-26-9-7-17(12-26)24-20(28)16-3-4-19-15(11-16)6-10-27(19)21-23-8-5-18(25-21)14-1-2-14/h3-5,8,11,14,17H,1-2,6-7,9-10,12H2,(H,24,28)/t17-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404588((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Show SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1ccc2N(CCc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C22H24N6O/c1-26(18-8-10-27(13-18)14-23)21(29)17-4-5-20-16(12-17)7-11-28(20)22-24-9-6-19(25-22)15-2-3-15/h4-6,9,12,15,18H,2-3,7-8,10-11,13H2,1H3/t18-/m1/s1
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404344(US10343992, Example 3 | US10689345, Example 3 | US...)
Show SMILES Clc1ccccc1-c1ccc(cc1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C18H16ClN3O/c19-17-4-2-1-3-16(17)13-5-7-14(8-6-13)18(23)21-15-9-10-22(11-15)12-20/h1-8,15H,9-11H2,(H,21,23)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404342(US10343992, Example 1 | US10689345, Example 1 | US...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C17H16N4O/c18-12-21-9-8-15(11-21)20-17(22)16-7-6-14(10-19-16)13-4-2-1-3-5-13/h1-7,10,15H,8-9,11H2,(H,20,22)/t15-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404345(US10343992, Example 4 | US10689345, Example 4 | US...)
Show SMILES CN(Cc1ccccc1)c1ccc(cn1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C19H21N5O/c1-23(12-15-5-3-2-4-6-15)18-8-7-16(11-21-18)19(25)22-17-9-10-24(13-17)14-20/h2-8,11,17H,9-10,12-13H2,1H3,(H,22,25)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404346(US10343992, Example 5 | US10689345, Example 5 | US...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)c1ccccc1
Show InChI InChI=1S/C15H18N4O/c16-11-18-7-6-14(10-18)17-15(20)19-8-13(9-19)12-4-2-1-3-5-12/h1-5,13-14H,6-10H2,(H,17,20)/t14-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404347(US10343992, Example 6 | US10689345, Example 6 | US...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ccc(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H23FN4O2/c1-12-8-23(9-13(2)25-12)17-4-3-14(7-16(17)19)18(24)21-15-5-6-22(10-15)11-20/h3-4,7,12-13,15H,5-6,8-10H2,1-2H3,(H,21,24)/t12-,13+,15-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514217(N-(1-cyanopyrrolidin-3-yl)-4- phenylthiazole-2-car...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C15H14N4OS/c16-10-19-7-6-12(8-19)17-14(20)15-18-13(9-21-15)11-4-2-1-3-5-11/h1-5,9,12H,6-8H2,(H,17,20)/t12-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514219(N-(1-cyanopyrrolidin-3-yl)-1- phenyl-1H-imidazole-...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1cn(cn1)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c16-10-19-7-6-12(8-19)18-15(21)14-9-20(11-17-14)13-4-2-1-3-5-13/h1-5,9,11-12H,6-8H2,(H,18,21)/t12-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514220(N-(1-cyanopyrrolidin-3-yl)-1-(2,4- difluorophenyl)...)
Show SMILES Fc1ccc(CN2CC(CC2=O)C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-2-1-11(15(19)6-13)7-23-8-12(5-16(23)24)17(25)21-14-3-4-22(9-14)10-20/h1-2,6,12,14H,3-5,7-9H2,(H,21,25)/t12?,14-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514222(N-(1-cyanopyrrolidin-3-yl)-4-(3,5- dimethylisoxazo...)
Show SMILES Cc1noc(C)c1-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H18N4O2/c1-11-16(12(2)23-20-11)13-3-5-14(6-4-13)17(22)19-15-7-8-21(9-15)10-18/h3-6,15H,7-9H2,1-2H3,(H,19,22)/t15-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514230(N-(1-cyanopyrrolidin-3-yl)-6-(4- (2,4-difluorophen...)
Show SMILES Fc1ccc(N2CCN(CC2)c2ccc(cn2)C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C21H22F2N6O/c22-16-2-3-19(18(23)11-16)28-7-9-29(10-8-28)20-4-1-15(12-25-20)21(30)26-17-5-6-27(13-17)14-24/h1-4,11-12,17H,5-10,13H2,(H,26,30)/t17-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM447523((R)—N-(1-cyanopyrrolidin-3-yl)-3-(N-methyliso...)
Show SMILES CC(C)C(=O)N(C)c1cccc(c1)C(=O)N[C@@H]1CCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H31N3O4/c1-14(2)19(26)23(6)17-9-7-8-15(12-17)18(25)22-16-10-11-24(13-16)20(27)28-21(3,4)5/h7-9,12,14,16H,10-11,13H2,1-6H3,(H,22,25)/t16-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM447524((R)—N-(1-cyanopyrrolidin-3-yl)-5-phenylpyrimi...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C20H24N4O3/c1-20(2,3)27-19(26)24-10-9-16(13-24)23-18(25)17-21-11-15(12-22-17)14-7-5-4-6-8-14/h4-8,11-12,16H,9-10,13H2,1-3H3,(H,23,25)/t16-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM447525((R)—N-(1-cyanopyrrolidin-3-yl)-3-(pyridin-4-y...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1cc(no1)-c1ccncc1
Show InChI InChI=1S/C18H22N4O4/c1-18(2,3)25-17(24)22-9-6-13(11-22)20-16(23)15-10-14(21-26-15)12-4-7-19-8-5-12/h4-5,7-8,10,13H,6,9,11H2,1-3H3,(H,20,23)/t13-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514235((R)—N-(1-cyanopyrrolidin-3-yl)-5-phenylpyrida...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1cc(cnn1)-c1ccccc1
Show InChI InChI=1S/C20H24N4O3/c1-20(2,3)27-19(26)24-10-9-16(13-24)22-18(25)17-11-15(12-21-23-17)14-7-5-4-6-8-14/h4-8,11-12,16H,9-10,13H2,1-3H3,(H,22,25)/t16-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM514236(N-(1-cyanopyrrolidin-3-yl)-N-methyl-[1,1′-bi...)
Show SMILES CN(C1CCN(C1)C(=O)OC(C)(C)C)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H28N2O3/c1-23(2,3)28-22(27)25-15-14-20(16-25)24(4)21(26)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,20H,14-16H2,1-4H3
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
MISSION THERAPEUTICS LIMITED

US Patent
LigandPNGBDBM404421(US10343992, Example 73 | US10689345, Example 73 | ...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccnc(c1)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H19N5O/c20-13-23-8-6-17(12-23)22-19(25)14-5-7-21-18(9-14)24-10-15-3-1-2-4-16(15)11-24/h1-5,7,9,17H,6,8,10-12H2,(H,22,25)/t17-/m1/s1
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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